CAnceR IN PreGnancy (CARING) – a retrospective study of cancer diagnosed during pregnancy in the United Kingdom

Background The incidence of cancer diagnosed during pregnancy is increasing. Data relating to investigation and management, as well as maternal and foetal outcomes is lacking in a United Kingdom (UK) population. Methods In this retrospective study we report data from 119 patients diagnosed with canc...

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Veröffentlicht in:British journal of cancer 2024-05, Vol.130 (8), p.1261-1268
Hauptverfasser: Baxter, M. A., Denholm, M., Kingdon, S. J., Kathirgamakarthigeyan, S., Parikh, S., Shakir, R., Johnson, R., Martin, H., Walton, M., Yao, W., Swan, A., Samuelson, C., Ren, X., Cooper, A., Gray, H-L, Clifton, S., Ball, J., Gullick, G., Anderson, M., Dodd, L., Hayhurst, H., Salama, M., Shotton, R., Britton, F., Christodoulou, T., Abdul-Hamid, A., Eichholz, A., Evans, R. M., Wallroth, P., Gibson, F., Poole, K., Rowe, M., Harris, J.
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container_end_page 1268
container_issue 8
container_start_page 1261
container_title British journal of cancer
container_volume 130
creator Baxter, M. A.
Denholm, M.
Kingdon, S. J.
Kathirgamakarthigeyan, S.
Parikh, S.
Shakir, R.
Johnson, R.
Martin, H.
Walton, M.
Yao, W.
Swan, A.
Samuelson, C.
Ren, X.
Cooper, A.
Gray, H-L
Clifton, S.
Ball, J.
Gullick, G.
Anderson, M.
Dodd, L.
Hayhurst, H.
Salama, M.
Shotton, R.
Britton, F.
Christodoulou, T.
Abdul-Hamid, A.
Eichholz, A.
Evans, R. M.
Wallroth, P.
Gibson, F.
Poole, K.
Rowe, M.
Harris, J.
description Background The incidence of cancer diagnosed during pregnancy is increasing. Data relating to investigation and management, as well as maternal and foetal outcomes is lacking in a United Kingdom (UK) population. Methods In this retrospective study we report data from 119 patients diagnosed with cancer during pregnancy from 14 cancer centres in the UK across a five-year period (2016-2020). Results Median age at diagnosis was 33 years, with breast, skin and haematological the most common primary sites. The majority of cases were new diagnoses (109 patients, 91.6%). Most patients were treated with radical intent (96 patients, 80.7%), however, gastrointestinal cancers were associated with a high rate of palliative intent treatment (63.6%). Intervention was commenced during pregnancy in 68 (57.1%) patients; 44 (37%) had surgery and 31 (26.1%) received chemotherapy. Live births occurred in 98 (81.7%) of the cases, with 54 (55.1%) of these delivered by caesarean section. Maternal mortality during the study period was 20.2%. Conclusions This is the first pan-tumour report of diagnosis, management and outcomes of cancer diagnosed during pregnancy in the UK. Our findings demonstrate proof of concept that data collection is feasible and highlight the need for further research in this cohort of patients.
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A. ; Denholm, M. ; Kingdon, S. J. ; Kathirgamakarthigeyan, S. ; Parikh, S. ; Shakir, R. ; Johnson, R. ; Martin, H. ; Walton, M. ; Yao, W. ; Swan, A. ; Samuelson, C. ; Ren, X. ; Cooper, A. ; Gray, H-L ; Clifton, S. ; Ball, J. ; Gullick, G. ; Anderson, M. ; Dodd, L. ; Hayhurst, H. ; Salama, M. ; Shotton, R. ; Britton, F. ; Christodoulou, T. ; Abdul-Hamid, A. ; Eichholz, A. ; Evans, R. M. ; Wallroth, P. ; Gibson, F. ; Poole, K. ; Rowe, M. ; Harris, J.</creator><creatorcontrib>Baxter, M. A. ; Denholm, M. ; Kingdon, S. J. ; Kathirgamakarthigeyan, S. ; Parikh, S. ; Shakir, R. ; Johnson, R. ; Martin, H. ; Walton, M. ; Yao, W. ; Swan, A. ; Samuelson, C. ; Ren, X. ; Cooper, A. ; Gray, H-L ; Clifton, S. ; Ball, J. ; Gullick, G. ; Anderson, M. ; Dodd, L. ; Hayhurst, H. ; Salama, M. ; Shotton, R. ; Britton, F. ; Christodoulou, T. ; Abdul-Hamid, A. ; Eichholz, A. ; Evans, R. M. ; Wallroth, P. ; Gibson, F. ; Poole, K. ; Rowe, M. ; Harris, J. ; National Oncology Trainees Collaborative for Healthcare Research (NOTCH)</creatorcontrib><description>Background The incidence of cancer diagnosed during pregnancy is increasing. Data relating to investigation and management, as well as maternal and foetal outcomes is lacking in a United Kingdom (UK) population. Methods In this retrospective study we report data from 119 patients diagnosed with cancer during pregnancy from 14 cancer centres in the UK across a five-year period (2016-2020). Results Median age at diagnosis was 33 years, with breast, skin and haematological the most common primary sites. The majority of cases were new diagnoses (109 patients, 91.6%). Most patients were treated with radical intent (96 patients, 80.7%), however, gastrointestinal cancers were associated with a high rate of palliative intent treatment (63.6%). Intervention was commenced during pregnancy in 68 (57.1%) patients; 44 (37%) had surgery and 31 (26.1%) received chemotherapy. Live births occurred in 98 (81.7%) of the cases, with 54 (55.1%) of these delivered by caesarean section. Maternal mortality during the study period was 20.2%. Conclusions This is the first pan-tumour report of diagnosis, management and outcomes of cancer diagnosed during pregnancy in the UK. 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The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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A.</creatorcontrib><creatorcontrib>Denholm, M.</creatorcontrib><creatorcontrib>Kingdon, S. J.</creatorcontrib><creatorcontrib>Kathirgamakarthigeyan, S.</creatorcontrib><creatorcontrib>Parikh, S.</creatorcontrib><creatorcontrib>Shakir, R.</creatorcontrib><creatorcontrib>Johnson, R.</creatorcontrib><creatorcontrib>Martin, H.</creatorcontrib><creatorcontrib>Walton, M.</creatorcontrib><creatorcontrib>Yao, W.</creatorcontrib><creatorcontrib>Swan, A.</creatorcontrib><creatorcontrib>Samuelson, C.</creatorcontrib><creatorcontrib>Ren, X.</creatorcontrib><creatorcontrib>Cooper, A.</creatorcontrib><creatorcontrib>Gray, H-L</creatorcontrib><creatorcontrib>Clifton, S.</creatorcontrib><creatorcontrib>Ball, J.</creatorcontrib><creatorcontrib>Gullick, G.</creatorcontrib><creatorcontrib>Anderson, M.</creatorcontrib><creatorcontrib>Dodd, L.</creatorcontrib><creatorcontrib>Hayhurst, H.</creatorcontrib><creatorcontrib>Salama, M.</creatorcontrib><creatorcontrib>Shotton, R.</creatorcontrib><creatorcontrib>Britton, F.</creatorcontrib><creatorcontrib>Christodoulou, T.</creatorcontrib><creatorcontrib>Abdul-Hamid, A.</creatorcontrib><creatorcontrib>Eichholz, A.</creatorcontrib><creatorcontrib>Evans, R. 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Results Median age at diagnosis was 33 years, with breast, skin and haematological the most common primary sites. The majority of cases were new diagnoses (109 patients, 91.6%). Most patients were treated with radical intent (96 patients, 80.7%), however, gastrointestinal cancers were associated with a high rate of palliative intent treatment (63.6%). Intervention was commenced during pregnancy in 68 (57.1%) patients; 44 (37%) had surgery and 31 (26.1%) received chemotherapy. Live births occurred in 98 (81.7%) of the cases, with 54 (55.1%) of these delivered by caesarean section. Maternal mortality during the study period was 20.2%. Conclusions This is the first pan-tumour report of diagnosis, management and outcomes of cancer diagnosed during pregnancy in the UK. 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A.</au><au>Denholm, M.</au><au>Kingdon, S. J.</au><au>Kathirgamakarthigeyan, S.</au><au>Parikh, S.</au><au>Shakir, R.</au><au>Johnson, R.</au><au>Martin, H.</au><au>Walton, M.</au><au>Yao, W.</au><au>Swan, A.</au><au>Samuelson, C.</au><au>Ren, X.</au><au>Cooper, A.</au><au>Gray, H-L</au><au>Clifton, S.</au><au>Ball, J.</au><au>Gullick, G.</au><au>Anderson, M.</au><au>Dodd, L.</au><au>Hayhurst, H.</au><au>Salama, M.</au><au>Shotton, R.</au><au>Britton, F.</au><au>Christodoulou, T.</au><au>Abdul-Hamid, A.</au><au>Eichholz, A.</au><au>Evans, R. M.</au><au>Wallroth, P.</au><au>Gibson, F.</au><au>Poole, K.</au><au>Rowe, M.</au><au>Harris, J.</au><aucorp>National Oncology Trainees Collaborative for Healthcare Research (NOTCH)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CAnceR IN PreGnancy (CARING) – a retrospective study of cancer diagnosed during pregnancy in the United Kingdom</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2024-05-03</date><risdate>2024</risdate><volume>130</volume><issue>8</issue><spage>1261</spage><epage>1268</epage><pages>1261-1268</pages><issn>0007-0920</issn><issn>1532-1827</issn><eissn>1532-1827</eissn><abstract>Background The incidence of cancer diagnosed during pregnancy is increasing. Data relating to investigation and management, as well as maternal and foetal outcomes is lacking in a United Kingdom (UK) population. Methods In this retrospective study we report data from 119 patients diagnosed with cancer during pregnancy from 14 cancer centres in the UK across a five-year period (2016-2020). Results Median age at diagnosis was 33 years, with breast, skin and haematological the most common primary sites. The majority of cases were new diagnoses (109 patients, 91.6%). Most patients were treated with radical intent (96 patients, 80.7%), however, gastrointestinal cancers were associated with a high rate of palliative intent treatment (63.6%). Intervention was commenced during pregnancy in 68 (57.1%) patients; 44 (37%) had surgery and 31 (26.1%) received chemotherapy. Live births occurred in 98 (81.7%) of the cases, with 54 (55.1%) of these delivered by caesarean section. Maternal mortality during the study period was 20.2%. Conclusions This is the first pan-tumour report of diagnosis, management and outcomes of cancer diagnosed during pregnancy in the UK. Our findings demonstrate proof of concept that data collection is feasible and highlight the need for further research in this cohort of patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>38383704</pmid><doi>10.1038/s41416-024-02605-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5773-8650</orcidid><orcidid>https://orcid.org/0000-0001-8993-0148</orcidid><oa>free_for_read</oa></addata></record>
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ispartof British journal of cancer, 2024-05, Vol.130 (8), p.1261-1268
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subjects 631/67/2324
692/308/174
692/4028/67/2324
692/699/67/2324
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Cesarean Section
Chemotherapy
Data collection
Diagnosis
Drug Resistance
Epidemiology
Female
Humans
Live Birth
Molecular Medicine
Neoplasms - diagnosis
Neoplasms - epidemiology
Neoplasms - therapy
Oncology
Patients
Pregnancy
Retrospective Studies
United Kingdom - epidemiology
title CAnceR IN PreGnancy (CARING) – a retrospective study of cancer diagnosed during pregnancy in the United Kingdom
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