WNK kinase is a vasoactive chloride sensor in endothelial cells

Endothelial cells (ECs) line the wall of blood vessels and regulate arterial contractility to tune regional organ blood flow and systemic pressure. Chloride (Cl ) is the most abundant anion in ECs and the Cl sensitive With-No-Lysine (WNK) kinase is expressed in this cell type. Whether intracellular...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-04, Vol.121 (15), p.e2322135121
Hauptverfasser:	Garrud, Tessa A C, Bell, Briar, Mata-Daboin, Alejandro, Peixoto-Neves, Dieniffer, Collier, Daniel M, Cordero-Morales, Julio F, Jaggar, Jonathan H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteries Biological Sciences Blood flow Blood pressure Blood vessels C-Terminus Calcium (intracellular) Calcium channels Calcium ions Calcium signalling Channels Chlorides Chlorides - metabolism Contractility Endothelial cells Endothelial Cells - metabolism Intracellular Intracellular signalling Kinases Lysine Mice Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Signal Transduction - physiology Substrates Transient receptor potential proteins TRPV Cation Channels - metabolism Vasoactive agents Vasodilation
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