A MiR181/Sirtuin1 regulatory circuit modulates drug response in biliary cancers

Despite recent advances, biliary tract cancer (BTC) remains one of the most lethal tumor worldwide due to late diagnosis, limited therapeutic strategies and resistance to conventional therapies. In recent years, high-throughput technologies have enabled extensive genome, and transcriptome sequencing...

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Veröffentlicht in:	Clinical and experimental medicine 2024-04, Vol.24 (1), p.74, Article 74
Hauptverfasser:	Barbato, Anna, Piscopo, Fabiola, Salati, Massimiliano, Pollastro, Carla, Evangelista, Lorenzo, Ferrante, Luigi, Limongello, Davide, Brillante, Simona, Iuliano, Antonella, Reggiani-Bonetti, Luca, Salatiello, Maria, Iaccarino, Antonino, Pisapia, Pasquale, Malapelle, Umberto, Troncone, Giancarlo, Indrieri, Alessia, Dominici, Massimo, Franco, Brunella, Carotenuto, Pietro
Format:	Artikel
Sprache:	eng
Schlagworte:	Biliary tract Biliary tract diseases Biliary Tract Neoplasms - drug therapy Biliary Tract Neoplasms - genetics Biomarkers Cell Line Cell Survival Cell viability Chemotherapy Hematology Humans Internal Medicine Medical prognosis Medicine Medicine & Public Health MicroRNAs MicroRNAs - genetics miRNA Oncology Precision medicine SIRT1 protein Sirtuin 1 - genetics Survival analysis Therapeutic targets Transcriptomes Tumor suppressor genes Tumors
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