Neuropeptide W facilitates chronic gastric ulcer healing by the regulation of cyclooxygenase and NF-κB signaling pathways

Aims Putative beneficial effects of neuropeptide W (NPW) in the early phase of gastric ulcer healing process and the involvement of cyclooxygenase (COX) enzymes were investigated in an acetic acid-induced gastric ulcer model. Main methods In anesthetized male Sprague–Dawley rats, acetic acid was app...

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Veröffentlicht in:	Inflammopharmacology 2024-04, Vol.32 (2), p.1519-1529
Hauptverfasser:	Arabacı Tamer, Sevil, Mermer, Kadriye Sezen, Erdoğan, Ömer, Çevik, Özge, Ercan, Feriha, Bağcı, Cahit, Yeğen, Berrak Ç.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - pharmacology Allergology Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biomedical and Life Sciences Biomedicine Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - metabolism Cyclooxygenase Inhibitors - pharmacology Dermatology Gastric Mucosa Gastroenterology Glutathione - metabolism Immunology Indomethacin - pharmacology Ketorolac - adverse effects Male Neuropeptides - metabolism Neuropeptides - pharmacology Neuropeptides - therapeutic use NF-kappa B - metabolism Omeprazole - pharmacology Omeprazole - therapeutic use Original Original Article Peroxidase - metabolism Pharmacology/Toxicology Rats Rats, Sprague-Dawley Rheumatology Signal Transduction Stomach Ulcer - chemically induced Stomach Ulcer - drug therapy Ulcer - metabolism Ulcer - pathology
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