Antagomir of miR-31-5p modulates macrophage polarization via the AMPK/SIRT1/NLRP3 signaling pathway to protect against DSS-induced colitis in mice

Macrophage-driven immune dysfunction of the intestinal mucosa is involved in the pathophysiology of ulcerative colitis (UC). Emerging evidence indicates that there is an elevation in miR-31-5p levels in UC, which is accompanied by a downregulation of adenosine 5'-monophosphate (AMP)-activated p...

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Veröffentlicht in:Aging (Albany, NY.) NY.), 2024-03, Vol.16 (6), p.5336-5353
Hauptverfasser: Yuan, Yuyi, Deng, Shuangjiao, Yang, Jia, Shou, Zhexing, Wei, Chunzhu, Zhang, Lijuan, Zhu, Feng, Gao, Fei, Liu, Xingxing, Liu, Yujin, Chen, Qianyun, Fan, Heng
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Sprache:eng
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