Targeting Gαi/s Proteins with Peptidyl Nucleotide Exchange Modulators

Chemical probes that specifically modulate the activity of heterotrimeric G proteins provide excellent tools for investigating G protein-mediated cell signaling. Herein, we report a family of selective peptidyl Gαi/s modulators derived from peptide library screening and optimization. Conjugation to...

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Veröffentlicht in:	ACS chemical biology 2022-02, Vol.17 (2), p.463-473
Hauptverfasser:	Nubbemeyer, Britta, Paul George, Ajay Abisheck, Kühl, Toni, Pepanian, Anna, Beck, Maximilian Steve, Maghraby, Rahma, Shetab Boushehri, Maryam, Muehlhaupt, Maximilian, Pfeil, Eva Marie, Annala, Suvi Katariina, Ammer, Hermann, Imhof, Diana, Pei, Dehua
Format:	Artikel
Sprache:	eng
Schlagworte:	Heterotrimeric GTP-Binding Proteins - metabolism Heterotrimeric GTP-Binding Proteins - pharmacology Molecular Docking Simulation Nucleotides - metabolism Peptides - chemistry Signal Transduction
Online-Zugang:	Volltext
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