Mitotic abnormalities precede microsatellite instability in lynch syndrome-associated colorectal tumourigenesis

Lynch syndrome (LS) is one of the most common hereditary cancer syndromes worldwide. Dominantly inherited mutation in one of four DNA mismatch repair genes combined with somatic events leads to mismatch repair deficiency and microsatellite instability (MSI) in tumours. Due to a high lifetime risk of...

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Veröffentlicht in:	EBioMedicine 2024-05, Vol.103, p.105111-105111, Article 105111
Hauptverfasser:	Pussila, Marjaana, Laiho, Aleksi, Törönen, Petri, Björkbacka, Pauliina, Nykänen, Sonja, Pylvänäinen, Kirsi, Holm, Liisa, Mecklin, Jukka-Pekka, Renkonen-Sinisalo, Laura, Lehtonen, Taru, Lepistö, Anna, Linden, Jere, Mäki-Nevala, Satu, Peltomäki, Päivi, Nyström, Minna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Carcinogenesis - genetics Chromosomal instability Colon cancer Colorectal Neoplasms - etiology Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal Neoplasms, Hereditary Nonpolyposis - complications Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - pathology DNA Mismatch Repair - genetics Female Field defect Gene Expression Profiling Humans Lynch syndrome Male Microsatellite Instability Middle Aged Mismatch repair Mitosis - genetics Mutation MutL Protein Homolog 1 - genetics Transcriptome
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