Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB–dependent IFITM3 expression

The innate immune system features a web of interacting pathways that require exquisite regulation. To identify novel nodes in this immune landscape, we conducted a gain-of-function, genome-wide CRISPR activation screen with influenza A virus. We identified both appreciated and novel antiviral genes,...

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Veröffentlicht in:	The Journal of biological chemistry 2024-04, Vol.300 (4), p.107153-107153, Article 107153
Hauptverfasser:	Munir, Moiz, Embry, Aaron, Doench, John G., Heaton, Nicholas S., Wilen, Craig B., Orchard, Robert C.
Format:	Artikel
Sprache:	eng
Schlagworte:	CRISPR/Cas9 screen histone acetylation IFITM3 inflammation influenza A virus JADE NF-kB
Online-Zugang:	Volltext
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