ODF3B affects the proliferation and apoptosis of glioma via the JAK/STAT pathway
The pathogenesis of glioma has remained unclear. In this study, it was found that high expression of the outer dense fibers of sperm tail 3B (ODF3B) in gliomas was positively correlated with the grade of glioma. The higher the grade, the worse the prognosis. ODF3B is closely related to the growth an...
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| Veröffentlicht in: | American journal of cancer research 2024-01, Vol.14 (3), p.1419-1432 |
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| container_title | American journal of cancer research |
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| creator | Luan, Xing-Zhao Yuan, Su-Xin Chen, Xiao-Jing Zhou, Yu-Ru Tang, Hua Li, Jia-Qi Jiang, Gen Yang, Lu-Xia Luo, Mao-Wen Tian, Jun-Jie Wen, Yu-Qi Zhang, Wen-Yan Chen, Li-Gang Xiang, Wei Zhou, Jie |
| description | The pathogenesis of glioma has remained unclear. In this study, it was found that high expression of the outer dense fibers of sperm tail 3B (ODF3B) in gliomas was positively correlated with the grade of glioma. The higher the grade, the worse the prognosis. ODF3B is closely related to the growth and apoptosis of glioma. In terms of mechanism, ODF3B was found to affect the proliferation and apoptosis of glioma through the JAK1 and JAK2/STAT3 pathways. ODF3B was also found to affect the growth and apoptosis of glioma
. We conclude that ODF3B affects glioma proliferation and apoptosis via the JAK/STAT pathway and is a potential therapeutic target. |
| doi_str_mv | 10.62347/GHKF1995 |
| format | Article |
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| title | ODF3B affects the proliferation and apoptosis of glioma via the JAK/STAT pathway |
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