The role of the aryl hydrocarbon receptor in mediating the effects of mono(2-ethylhexyl) phthalate in mouse ovarian antral follicles

Di(2-ethylhexyl) phthalate (DEHP) is a pervasive environmental toxicant used in the manufacturing of numerous consumer products, medical supplies, and building materials. DEHP is metabolized to mono(2-ethylhexyl) phthalate (MEHP). MEHP is an endocrine disruptor that adversely affects folliculogenesi...

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Veröffentlicht in:	Biology of reproduction 2024-03, Vol.110 (3), p.632-641
Hauptverfasser:	Neff, Alison M., Inman, Zane, Mourikes, Vasiliki E., Santacruz-Márquez, Ramsés, Gonsioroski, Andressa, Laws, Mary J., Flaws, Jodi A.
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals antagonists aryl hydrocarbon receptor aryl hydrocarbon receptors Azo Compounds chorionic gonadotropins coculture Culture media cytochrome P-450 Cytochrome P450 Diethylhexyl Phthalate - analogs & derivatives Diethylhexyl Phthalate - toxicity endocrine-disrupting chemicals estradiol Estrogens Estrone Female Follicles follicular development Folliculogenesis Hydrocarbons Luteinizing hormone mechanism of action Mice Ovaries ovary phthalates Phthalic Acids Progesterone progesterone receptors Pyrazoles Receptors, Aryl Hydrocarbon - metabolism reproduction RESEARCH ARTICLE Steroidogenesis Toxicants
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