Distribution, phenotype, functional and clinical relevance of CD8+CD103+ tissue-resident memory T cells in human gastric cancer
CD8 + CD103 + tissue-resident memory T cells (TRMs) are involved in tumor immune response and linked to favorable clinical outcome in human cancer. However, the distribution, phenotype, functional properties and clinical relevance of these cells in gastric cancer (GC) remain elusive. Here, our data...
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| Veröffentlicht in: | Cancer Immunology, Immunotherapy Immunotherapy, 2022-07, Vol.71 (7), p.1645-1654 |
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| container_title | Cancer Immunology, Immunotherapy |
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| creator | Shen, Yang Li, Xiao-long Li, Yu-xian Shan, Zhi-guo Zhao, Yong-liang Cheng, Ping Zhao, Zhuo Zhang, Jin-yu Chen, Weisan Zhuang, Yuan Ma, Dai-yuan Zou, Quan-ming Qiu, Yuan Peng, Liu-sheng |
| description | CD8
+
CD103
+
tissue-resident memory T cells (TRMs) are involved in tumor immune response and linked to favorable clinical outcome in human cancer. However, the distribution, phenotype, functional properties and clinical relevance of these cells in gastric cancer (GC) remain elusive. Here, our data show that, in comparison to non-tumor tissues, the percentages of CD8
+
CD103
+
TRMs in tumors are significantly decreased. Most tumor-infiltrating CD8
+
CD103
+
TRMs are CD45RA
−
CCR7
−
effector-memory cells with higher PD-1 and 4-1BB expression than those from non-tumor tissues. Further, tumor-infiltrating CD8
+
CD103
+
TRMs show impaired cytolytic capacity due to decreased granzyme B and perforin expression. Moreover, ex vivo PD-1 blockade could restore the cytolytic capacity of tumor-infiltrating CD8
+
CD103
+
TRMs, and such anti-PD-1-mediated reinvigoration of CD8
+
CD103
+
TRMs could be further enhanced by 4-1BB co-stimulation. Finally, lower levels of Tumor-infiltrating CD8
+
CD103
+
TRMs are positively correlated with GC progression and poor patients’ survival. Our data suggest that restoring CD8
+
CD103
+
TRM function by combining PD-1 blockade and 4-1BB co-stimulation may be a promising strategy for treating GC. |
| doi_str_mv | 10.1007/s00262-021-03105-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10992218</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2675275217</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-73fec00fead2fd7b58c949444c0dd1a9eb7179f8444dc9dbc2f1cd8bcd92cae43</originalsourceid><addsrcrecordid>eNp9UctuEzEUtRCIpoEfYIEssUFqB649nni8QijhJVViU9aWx76TuJqxgz1TKSt-vQ4p5bFAsvw49_jcxyHkBYM3DEC-zQB8xSvgrIKaQVPBI7Jgoi5Q27DHZAG1gEoCiDNynvNNuXBQ6ik5q4VcSRDNgvzY-Dwl382Tj-GS7ncY4nTY4yXt52CPoBmoCY7awQdvyyPhgLcmWKSxp-tNe7HeMKgv6ORznrFKmL3DMNERx5gO9JpaHIZMfaC7eTSBbs0xoaX2qJGekSe9GTI-vz-X5NvHD9frz9XV109f1u-vKiugmSpZ92gBejSO9052TWuVUEIIC84xo7CTTKq-LYizynWW98y6trNOcWtQ1Evy7qS7n7sRnS0VJjPoffKjSQcdjdd_R4Lf6W281axMjHPWFoXX9wopfp8xT3r0-dibCRjnrHmjpFDA5KpQX_1DvYlzKpMsrJVseFlMFhY_sWyKOSfsH6phoI8G65PBuhisfxpc9iV5-WcfD19-OVoI9YmQSyhsMf3O_R_ZO3ugswU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2675275217</pqid></control><display><type>article</type><title>Distribution, phenotype, functional and clinical relevance of CD8+CD103+ tissue-resident memory T cells in human gastric cancer</title><source>MEDLINE</source><source>SpringerNature Journals</source><source>PubMed Central</source><creator>Shen, Yang ; Li, Xiao-long ; Li, Yu-xian ; Shan, Zhi-guo ; Zhao, Yong-liang ; Cheng, Ping ; Zhao, Zhuo ; Zhang, Jin-yu ; Chen, Weisan ; Zhuang, Yuan ; Ma, Dai-yuan ; Zou, Quan-ming ; Qiu, Yuan ; Peng, Liu-sheng</creator><creatorcontrib>Shen, Yang ; Li, Xiao-long ; Li, Yu-xian ; Shan, Zhi-guo ; Zhao, Yong-liang ; Cheng, Ping ; Zhao, Zhuo ; Zhang, Jin-yu ; Chen, Weisan ; Zhuang, Yuan ; Ma, Dai-yuan ; Zou, Quan-ming ; Qiu, Yuan ; Peng, Liu-sheng</creatorcontrib><description>CD8
+
CD103
+
tissue-resident memory T cells (TRMs) are involved in tumor immune response and linked to favorable clinical outcome in human cancer. However, the distribution, phenotype, functional properties and clinical relevance of these cells in gastric cancer (GC) remain elusive. Here, our data show that, in comparison to non-tumor tissues, the percentages of CD8
+
CD103
+
TRMs in tumors are significantly decreased. Most tumor-infiltrating CD8
+
CD103
+
TRMs are CD45RA
−
CCR7
−
effector-memory cells with higher PD-1 and 4-1BB expression than those from non-tumor tissues. Further, tumor-infiltrating CD8
+
CD103
+
TRMs show impaired cytolytic capacity due to decreased granzyme B and perforin expression. Moreover, ex vivo PD-1 blockade could restore the cytolytic capacity of tumor-infiltrating CD8
+
CD103
+
TRMs, and such anti-PD-1-mediated reinvigoration of CD8
+
CD103
+
TRMs could be further enhanced by 4-1BB co-stimulation. Finally, lower levels of Tumor-infiltrating CD8
+
CD103
+
TRMs are positively correlated with GC progression and poor patients’ survival. Our data suggest that restoring CD8
+
CD103
+
TRM function by combining PD-1 blockade and 4-1BB co-stimulation may be a promising strategy for treating GC.</description><identifier>ISSN: 0340-7004</identifier><identifier>EISSN: 1432-0851</identifier><identifier>DOI: 10.1007/s00262-021-03105-0</identifier><identifier>PMID: 34767045</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cancer Research ; CCR7 protein ; CD103 antigen ; CD45RA antigen ; CD8 antigen ; CD8-Positive T-Lymphocytes ; Effector cells ; Gastric cancer ; Granzyme B ; Humans ; Immunologic Memory ; Immunological memory ; Immunology ; Integrin alpha Chains - metabolism ; Lymphocytes T ; Lymphocytes, Tumor-Infiltrating ; Medicine ; Medicine & Public Health ; Memory cells ; Memory T Cells ; Oncology ; Original ; Original Article ; PD-1 protein ; Perforin ; Phenotype ; Phenotypes ; Programmed Cell Death 1 Receptor - metabolism ; Stomach Neoplasms - metabolism</subject><ispartof>Cancer Immunology, Immunotherapy, 2022-07, Vol.71 (7), p.1645-1654</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-73fec00fead2fd7b58c949444c0dd1a9eb7179f8444dc9dbc2f1cd8bcd92cae43</citedby><cites>FETCH-LOGICAL-c405t-73fec00fead2fd7b58c949444c0dd1a9eb7179f8444dc9dbc2f1cd8bcd92cae43</cites><orcidid>0000-0002-8798-6006</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10992218/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10992218/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,41493,42562,51324,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34767045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Yang</creatorcontrib><creatorcontrib>Li, Xiao-long</creatorcontrib><creatorcontrib>Li, Yu-xian</creatorcontrib><creatorcontrib>Shan, Zhi-guo</creatorcontrib><creatorcontrib>Zhao, Yong-liang</creatorcontrib><creatorcontrib>Cheng, Ping</creatorcontrib><creatorcontrib>Zhao, Zhuo</creatorcontrib><creatorcontrib>Zhang, Jin-yu</creatorcontrib><creatorcontrib>Chen, Weisan</creatorcontrib><creatorcontrib>Zhuang, Yuan</creatorcontrib><creatorcontrib>Ma, Dai-yuan</creatorcontrib><creatorcontrib>Zou, Quan-ming</creatorcontrib><creatorcontrib>Qiu, Yuan</creatorcontrib><creatorcontrib>Peng, Liu-sheng</creatorcontrib><title>Distribution, phenotype, functional and clinical relevance of CD8+CD103+ tissue-resident memory T cells in human gastric cancer</title><title>Cancer Immunology, Immunotherapy</title><addtitle>Cancer Immunol Immunother</addtitle><addtitle>Cancer Immunol Immunother</addtitle><description>CD8
+
CD103
+
tissue-resident memory T cells (TRMs) are involved in tumor immune response and linked to favorable clinical outcome in human cancer. However, the distribution, phenotype, functional properties and clinical relevance of these cells in gastric cancer (GC) remain elusive. Here, our data show that, in comparison to non-tumor tissues, the percentages of CD8
+
CD103
+
TRMs in tumors are significantly decreased. Most tumor-infiltrating CD8
+
CD103
+
TRMs are CD45RA
−
CCR7
−
effector-memory cells with higher PD-1 and 4-1BB expression than those from non-tumor tissues. Further, tumor-infiltrating CD8
+
CD103
+
TRMs show impaired cytolytic capacity due to decreased granzyme B and perforin expression. Moreover, ex vivo PD-1 blockade could restore the cytolytic capacity of tumor-infiltrating CD8
+
CD103
+
TRMs, and such anti-PD-1-mediated reinvigoration of CD8
+
CD103
+
TRMs could be further enhanced by 4-1BB co-stimulation. Finally, lower levels of Tumor-infiltrating CD8
+
CD103
+
TRMs are positively correlated with GC progression and poor patients’ survival. Our data suggest that restoring CD8
+
CD103
+
TRM function by combining PD-1 blockade and 4-1BB co-stimulation may be a promising strategy for treating GC.</description><subject>Cancer Research</subject><subject>CCR7 protein</subject><subject>CD103 antigen</subject><subject>CD45RA antigen</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes</subject><subject>Effector cells</subject><subject>Gastric cancer</subject><subject>Granzyme B</subject><subject>Humans</subject><subject>Immunologic Memory</subject><subject>Immunological memory</subject><subject>Immunology</subject><subject>Integrin alpha Chains - metabolism</subject><subject>Lymphocytes T</subject><subject>Lymphocytes, Tumor-Infiltrating</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Memory cells</subject><subject>Memory T Cells</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>PD-1 protein</subject><subject>Perforin</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Programmed Cell Death 1 Receptor - metabolism</subject><subject>Stomach Neoplasms - metabolism</subject><issn>0340-7004</issn><issn>1432-0851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UctuEzEUtRCIpoEfYIEssUFqB649nni8QijhJVViU9aWx76TuJqxgz1TKSt-vQ4p5bFAsvw49_jcxyHkBYM3DEC-zQB8xSvgrIKaQVPBI7Jgoi5Q27DHZAG1gEoCiDNynvNNuXBQ6ik5q4VcSRDNgvzY-Dwl382Tj-GS7ncY4nTY4yXt52CPoBmoCY7awQdvyyPhgLcmWKSxp-tNe7HeMKgv6ORznrFKmL3DMNERx5gO9JpaHIZMfaC7eTSBbs0xoaX2qJGekSe9GTI-vz-X5NvHD9frz9XV109f1u-vKiugmSpZ92gBejSO9052TWuVUEIIC84xo7CTTKq-LYizynWW98y6trNOcWtQ1Evy7qS7n7sRnS0VJjPoffKjSQcdjdd_R4Lf6W281axMjHPWFoXX9wopfp8xT3r0-dibCRjnrHmjpFDA5KpQX_1DvYlzKpMsrJVseFlMFhY_sWyKOSfsH6phoI8G65PBuhisfxpc9iV5-WcfD19-OVoI9YmQSyhsMf3O_R_ZO3ugswU</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Shen, Yang</creator><creator>Li, Xiao-long</creator><creator>Li, Yu-xian</creator><creator>Shan, Zhi-guo</creator><creator>Zhao, Yong-liang</creator><creator>Cheng, Ping</creator><creator>Zhao, Zhuo</creator><creator>Zhang, Jin-yu</creator><creator>Chen, Weisan</creator><creator>Zhuang, Yuan</creator><creator>Ma, Dai-yuan</creator><creator>Zou, Quan-ming</creator><creator>Qiu, Yuan</creator><creator>Peng, Liu-sheng</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8798-6006</orcidid></search><sort><creationdate>20220701</creationdate><title>Distribution, phenotype, functional and clinical relevance of CD8+CD103+ tissue-resident memory T cells in human gastric cancer</title><author>Shen, Yang ; Li, Xiao-long ; Li, Yu-xian ; Shan, Zhi-guo ; Zhao, Yong-liang ; Cheng, Ping ; Zhao, Zhuo ; Zhang, Jin-yu ; Chen, Weisan ; Zhuang, Yuan ; Ma, Dai-yuan ; Zou, Quan-ming ; Qiu, Yuan ; Peng, Liu-sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-73fec00fead2fd7b58c949444c0dd1a9eb7179f8444dc9dbc2f1cd8bcd92cae43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cancer Research</topic><topic>CCR7 protein</topic><topic>CD103 antigen</topic><topic>CD45RA antigen</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes</topic><topic>Effector cells</topic><topic>Gastric cancer</topic><topic>Granzyme B</topic><topic>Humans</topic><topic>Immunologic Memory</topic><topic>Immunological memory</topic><topic>Immunology</topic><topic>Integrin alpha Chains - metabolism</topic><topic>Lymphocytes T</topic><topic>Lymphocytes, Tumor-Infiltrating</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Memory cells</topic><topic>Memory T Cells</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>PD-1 protein</topic><topic>Perforin</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Programmed Cell Death 1 Receptor - metabolism</topic><topic>Stomach Neoplasms - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Yang</creatorcontrib><creatorcontrib>Li, Xiao-long</creatorcontrib><creatorcontrib>Li, Yu-xian</creatorcontrib><creatorcontrib>Shan, Zhi-guo</creatorcontrib><creatorcontrib>Zhao, Yong-liang</creatorcontrib><creatorcontrib>Cheng, Ping</creatorcontrib><creatorcontrib>Zhao, Zhuo</creatorcontrib><creatorcontrib>Zhang, Jin-yu</creatorcontrib><creatorcontrib>Chen, Weisan</creatorcontrib><creatorcontrib>Zhuang, Yuan</creatorcontrib><creatorcontrib>Ma, Dai-yuan</creatorcontrib><creatorcontrib>Zou, Quan-ming</creatorcontrib><creatorcontrib>Qiu, Yuan</creatorcontrib><creatorcontrib>Peng, Liu-sheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer Immunology, Immunotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Yang</au><au>Li, Xiao-long</au><au>Li, Yu-xian</au><au>Shan, Zhi-guo</au><au>Zhao, Yong-liang</au><au>Cheng, Ping</au><au>Zhao, Zhuo</au><au>Zhang, Jin-yu</au><au>Chen, Weisan</au><au>Zhuang, Yuan</au><au>Ma, Dai-yuan</au><au>Zou, Quan-ming</au><au>Qiu, Yuan</au><au>Peng, Liu-sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution, phenotype, functional and clinical relevance of CD8+CD103+ tissue-resident memory T cells in human gastric cancer</atitle><jtitle>Cancer Immunology, Immunotherapy</jtitle><stitle>Cancer Immunol Immunother</stitle><addtitle>Cancer Immunol Immunother</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>71</volume><issue>7</issue><spage>1645</spage><epage>1654</epage><pages>1645-1654</pages><issn>0340-7004</issn><eissn>1432-0851</eissn><abstract>CD8
+
CD103
+
tissue-resident memory T cells (TRMs) are involved in tumor immune response and linked to favorable clinical outcome in human cancer. However, the distribution, phenotype, functional properties and clinical relevance of these cells in gastric cancer (GC) remain elusive. Here, our data show that, in comparison to non-tumor tissues, the percentages of CD8
+
CD103
+
TRMs in tumors are significantly decreased. Most tumor-infiltrating CD8
+
CD103
+
TRMs are CD45RA
−
CCR7
−
effector-memory cells with higher PD-1 and 4-1BB expression than those from non-tumor tissues. Further, tumor-infiltrating CD8
+
CD103
+
TRMs show impaired cytolytic capacity due to decreased granzyme B and perforin expression. Moreover, ex vivo PD-1 blockade could restore the cytolytic capacity of tumor-infiltrating CD8
+
CD103
+
TRMs, and such anti-PD-1-mediated reinvigoration of CD8
+
CD103
+
TRMs could be further enhanced by 4-1BB co-stimulation. Finally, lower levels of Tumor-infiltrating CD8
+
CD103
+
TRMs are positively correlated with GC progression and poor patients’ survival. Our data suggest that restoring CD8
+
CD103
+
TRM function by combining PD-1 blockade and 4-1BB co-stimulation may be a promising strategy for treating GC.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34767045</pmid><doi>10.1007/s00262-021-03105-0</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8798-6006</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0340-7004 |
| ispartof | Cancer Immunology, Immunotherapy, 2022-07, Vol.71 (7), p.1645-1654 |
| issn | 0340-7004 1432-0851 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals; PubMed Central |
| subjects | Cancer Research CCR7 protein CD103 antigen CD45RA antigen CD8 antigen CD8-Positive T-Lymphocytes Effector cells Gastric cancer Granzyme B Humans Immunologic Memory Immunological memory Immunology Integrin alpha Chains - metabolism Lymphocytes T Lymphocytes, Tumor-Infiltrating Medicine Medicine & Public Health Memory cells Memory T Cells Oncology Original Original Article PD-1 protein Perforin Phenotype Phenotypes Programmed Cell Death 1 Receptor - metabolism Stomach Neoplasms - metabolism |
| title | Distribution, phenotype, functional and clinical relevance of CD8+CD103+ tissue-resident memory T cells in human gastric cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T11%3A05%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Distribution,%20phenotype,%20functional%20and%20clinical%20relevance%20of%20CD8+CD103+%20tissue-resident%20memory%20T%20cells%20in%20human%20gastric%20cancer&rft.jtitle=Cancer%20Immunology,%20Immunotherapy&rft.au=Shen,%20Yang&rft.date=2022-07-01&rft.volume=71&rft.issue=7&rft.spage=1645&rft.epage=1654&rft.pages=1645-1654&rft.issn=0340-7004&rft.eissn=1432-0851&rft_id=info:doi/10.1007/s00262-021-03105-0&rft_dat=%3Cproquest_pubme%3E2675275217%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2675275217&rft_id=info:pmid/34767045&rfr_iscdi=true |