Retinoblastoma cell-derived Twist protein promotes regulatory T cell development
Background The development of tumor tissue-infiltrating regulatory T cell (Treg) is incompletely understood. This study investigates the role of retinoblastoma cell (Rbc)-derived Twist‑related protein 1 (Twist) in the Treg development. Methods The surgically removed Rb tissues were collected. Rbcs w...
Gespeichert in:
| Veröffentlicht in: | Cancer Immunology, Immunotherapy Immunotherapy, 2021-04, Vol.70 (4), p.1037-1048 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1048 |
|---|---|
| container_issue | 4 |
| container_start_page | 1037 |
| container_title | Cancer Immunology, Immunotherapy |
| container_volume | 70 |
| creator | Zhang, Ruishi Song, Yan-Nan Duo, Xiaoyan Guo, Zhihong Sun, Yanhua Zhang, Zhixiong Lu, Yongtian Miao, Beiping Yang, Ping-Chang Nie, Guohui |
| description | Background
The development of tumor tissue-infiltrating regulatory T cell (Treg) is incompletely understood. This study investigates the role of retinoblastoma cell (Rbc)-derived Twist‑related protein 1 (Twist) in the Treg development.
Methods
The surgically removed Rb tissues were collected. Rbcs were cultured with CD4
+
T cells to assess the role of Rbc-derived Twist in the Treg generation.
Results
We found that more than 90% Rbcs expressed Twist. Foxp3
+
Tregs were detected in the Rb tissues that were positively correlated with the Twist expression in Rbcs, negatively associated with Rb patient survival and sight survival. Treating Rbcs with hypoxia promoted the Twist expression that could be detected in the cytoplasm, nuclei and on the cell surface. Twist activated CD4
+
T cells by binding the TLR4/myeloid differentiation factor 2 complex and promoted the transforming growth factor-β-inducible early gene 1 product and Foxp3 expression. These Rbc-induced Foxp3
+
Tregs showed immune-suppressive function on CD8
+
T cell proliferation.
Conclusions
Rbcs express Twist, that induces IL-4
+
Foxp3
+
Tregs; the latter can inhibit CD8
+
cytotoxic T cell activities. Therefore, Twist may play an important role in the pathogenesis of Rb. |
| doi_str_mv | 10.1007/s00262-020-02744-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10992014</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2455171708</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-432e633f8e757ae2f34360c3709fa4d2ad14798c956e161b3191022e19e3cfc83</originalsourceid><addsrcrecordid>eNp9UctOwzAQtBCIlsIPcECRuHAJrB-JkxNCFS-pEgiVs-Umm5IqiYudFMHX41AojwMHa1fe2ZndHUIOKZxSAHnmAFjMQmDgnxQifNsiQyq4_0oiuk2GwAWEEkAMyJ5zC58wSNNdMuCcQiIkG5L7B2zLxswq7VpT6yDDqgpztOUK82D6Uro2WFrTYtn0sfaZCyzOu0q3xr4G04-GIMcVVmZZY9Puk51CVw4PPuOIPF5dTsc34eTu-nZ8MQkzwWkb-ikx5rxIUEZSIyu44DFkXEJaaJEznVMh0yRLoxhpTGecphQYQ5oiz4os4SNyvuZddrMa88xLW12ppS1rbV-V0aX6XWnKJzU3K0X9CRj4M43IySeDNc8dulbVpevX0Q2azikmoohKKqEXO_4DXZjONn4_xSLgIJI4Yh7F1qjMGucsFptpKKjeMbV2THnH1Idj6s03Hf3cY9PyZZEH8DXA-VIzR_ut_Q_tO9DPomM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2503048652</pqid></control><display><type>article</type><title>Retinoblastoma cell-derived Twist protein promotes regulatory T cell development</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>PubMed Central</source><creator>Zhang, Ruishi ; Song, Yan-Nan ; Duo, Xiaoyan ; Guo, Zhihong ; Sun, Yanhua ; Zhang, Zhixiong ; Lu, Yongtian ; Miao, Beiping ; Yang, Ping-Chang ; Nie, Guohui</creator><creatorcontrib>Zhang, Ruishi ; Song, Yan-Nan ; Duo, Xiaoyan ; Guo, Zhihong ; Sun, Yanhua ; Zhang, Zhixiong ; Lu, Yongtian ; Miao, Beiping ; Yang, Ping-Chang ; Nie, Guohui</creatorcontrib><description>Background
The development of tumor tissue-infiltrating regulatory T cell (Treg) is incompletely understood. This study investigates the role of retinoblastoma cell (Rbc)-derived Twist‑related protein 1 (Twist) in the Treg development.
Methods
The surgically removed Rb tissues were collected. Rbcs were cultured with CD4
+
T cells to assess the role of Rbc-derived Twist in the Treg generation.
Results
We found that more than 90% Rbcs expressed Twist. Foxp3
+
Tregs were detected in the Rb tissues that were positively correlated with the Twist expression in Rbcs, negatively associated with Rb patient survival and sight survival. Treating Rbcs with hypoxia promoted the Twist expression that could be detected in the cytoplasm, nuclei and on the cell surface. Twist activated CD4
+
T cells by binding the TLR4/myeloid differentiation factor 2 complex and promoted the transforming growth factor-β-inducible early gene 1 product and Foxp3 expression. These Rbc-induced Foxp3
+
Tregs showed immune-suppressive function on CD8
+
T cell proliferation.
Conclusions
Rbcs express Twist, that induces IL-4
+
Foxp3
+
Tregs; the latter can inhibit CD8
+
cytotoxic T cell activities. Therefore, Twist may play an important role in the pathogenesis of Rb.</description><identifier>ISSN: 0340-7004</identifier><identifier>EISSN: 1432-0851</identifier><identifier>DOI: 10.1007/s00262-020-02744-z</identifier><identifier>PMID: 33108472</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Apoptosis ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Cancer ; Cancer Research ; CD4 antigen ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; Cell differentiation ; Cell Proliferation ; Cell surface ; Cytoplasm ; Cytotoxicity ; Female ; Follow-Up Studies ; Foxp3 protein ; Gene Expression Regulation, Neoplastic ; Humans ; Hypoxia ; Immunology ; Interleukin 4 ; Lymphocytes ; Lymphocytes T ; Male ; Medicine ; Medicine & Public Health ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Oncology ; Original ; Original Article ; Prognosis ; Retina ; Retinal Neoplasms - immunology ; Retinal Neoplasms - metabolism ; Retinal Neoplasms - pathology ; Retinoblastoma ; Retinoblastoma - immunology ; Retinoblastoma - metabolism ; Retinoblastoma - pathology ; Retinoblastoma Protein - genetics ; Retinoblastoma Protein - metabolism ; T-Lymphocytes, Regulatory - immunology ; TLR4 protein ; Toll-like receptors ; Transforming growth factor-b ; Tumor Cells, Cultured ; Tumor Microenvironment - immunology ; Tumors ; Twist protein ; Twist-Related Protein 1 - genetics ; Twist-Related Protein 1 - metabolism</subject><ispartof>Cancer Immunology, Immunotherapy, 2021-04, Vol.70 (4), p.1037-1048</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-432e633f8e757ae2f34360c3709fa4d2ad14798c956e161b3191022e19e3cfc83</citedby><cites>FETCH-LOGICAL-c431t-432e633f8e757ae2f34360c3709fa4d2ad14798c956e161b3191022e19e3cfc83</cites><orcidid>0000-0002-3738-9385</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10992014/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10992014/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27913,27914,41477,42546,51308,53780,53782</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33108472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Ruishi</creatorcontrib><creatorcontrib>Song, Yan-Nan</creatorcontrib><creatorcontrib>Duo, Xiaoyan</creatorcontrib><creatorcontrib>Guo, Zhihong</creatorcontrib><creatorcontrib>Sun, Yanhua</creatorcontrib><creatorcontrib>Zhang, Zhixiong</creatorcontrib><creatorcontrib>Lu, Yongtian</creatorcontrib><creatorcontrib>Miao, Beiping</creatorcontrib><creatorcontrib>Yang, Ping-Chang</creatorcontrib><creatorcontrib>Nie, Guohui</creatorcontrib><title>Retinoblastoma cell-derived Twist protein promotes regulatory T cell development</title><title>Cancer Immunology, Immunotherapy</title><addtitle>Cancer Immunol Immunother</addtitle><addtitle>Cancer Immunol Immunother</addtitle><description>Background
The development of tumor tissue-infiltrating regulatory T cell (Treg) is incompletely understood. This study investigates the role of retinoblastoma cell (Rbc)-derived Twist‑related protein 1 (Twist) in the Treg development.
Methods
The surgically removed Rb tissues were collected. Rbcs were cultured with CD4
+
T cells to assess the role of Rbc-derived Twist in the Treg generation.
Results
We found that more than 90% Rbcs expressed Twist. Foxp3
+
Tregs were detected in the Rb tissues that were positively correlated with the Twist expression in Rbcs, negatively associated with Rb patient survival and sight survival. Treating Rbcs with hypoxia promoted the Twist expression that could be detected in the cytoplasm, nuclei and on the cell surface. Twist activated CD4
+
T cells by binding the TLR4/myeloid differentiation factor 2 complex and promoted the transforming growth factor-β-inducible early gene 1 product and Foxp3 expression. These Rbc-induced Foxp3
+
Tregs showed immune-suppressive function on CD8
+
T cell proliferation.
Conclusions
Rbcs express Twist, that induces IL-4
+
Foxp3
+
Tregs; the latter can inhibit CD8
+
cytotoxic T cell activities. Therefore, Twist may play an important role in the pathogenesis of Rb.</description><subject>Apoptosis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>CD4 antigen</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Cell differentiation</subject><subject>Cell Proliferation</subject><subject>Cell surface</subject><subject>Cytoplasm</subject><subject>Cytotoxicity</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Foxp3 protein</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Immunology</subject><subject>Interleukin 4</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Retina</subject><subject>Retinal Neoplasms - immunology</subject><subject>Retinal Neoplasms - metabolism</subject><subject>Retinal Neoplasms - pathology</subject><subject>Retinoblastoma</subject><subject>Retinoblastoma - immunology</subject><subject>Retinoblastoma - metabolism</subject><subject>Retinoblastoma - pathology</subject><subject>Retinoblastoma Protein - genetics</subject><subject>Retinoblastoma Protein - metabolism</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>TLR4 protein</subject><subject>Toll-like receptors</subject><subject>Transforming growth factor-b</subject><subject>Tumor Cells, Cultured</subject><subject>Tumor Microenvironment - immunology</subject><subject>Tumors</subject><subject>Twist protein</subject><subject>Twist-Related Protein 1 - genetics</subject><subject>Twist-Related Protein 1 - metabolism</subject><issn>0340-7004</issn><issn>1432-0851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UctOwzAQtBCIlsIPcECRuHAJrB-JkxNCFS-pEgiVs-Umm5IqiYudFMHX41AojwMHa1fe2ZndHUIOKZxSAHnmAFjMQmDgnxQifNsiQyq4_0oiuk2GwAWEEkAMyJ5zC58wSNNdMuCcQiIkG5L7B2zLxswq7VpT6yDDqgpztOUK82D6Uro2WFrTYtn0sfaZCyzOu0q3xr4G04-GIMcVVmZZY9Puk51CVw4PPuOIPF5dTsc34eTu-nZ8MQkzwWkb-ikx5rxIUEZSIyu44DFkXEJaaJEznVMh0yRLoxhpTGecphQYQ5oiz4os4SNyvuZddrMa88xLW12ppS1rbV-V0aX6XWnKJzU3K0X9CRj4M43IySeDNc8dulbVpevX0Q2azikmoohKKqEXO_4DXZjONn4_xSLgIJI4Yh7F1qjMGucsFptpKKjeMbV2THnH1Idj6s03Hf3cY9PyZZEH8DXA-VIzR_ut_Q_tO9DPomM</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Zhang, Ruishi</creator><creator>Song, Yan-Nan</creator><creator>Duo, Xiaoyan</creator><creator>Guo, Zhihong</creator><creator>Sun, Yanhua</creator><creator>Zhang, Zhixiong</creator><creator>Lu, Yongtian</creator><creator>Miao, Beiping</creator><creator>Yang, Ping-Chang</creator><creator>Nie, Guohui</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3738-9385</orcidid></search><sort><creationdate>20210401</creationdate><title>Retinoblastoma cell-derived Twist protein promotes regulatory T cell development</title><author>Zhang, Ruishi ; Song, Yan-Nan ; Duo, Xiaoyan ; Guo, Zhihong ; Sun, Yanhua ; Zhang, Zhixiong ; Lu, Yongtian ; Miao, Beiping ; Yang, Ping-Chang ; Nie, Guohui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-432e633f8e757ae2f34360c3709fa4d2ad14798c956e161b3191022e19e3cfc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Apoptosis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>CD4 antigen</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Cell differentiation</topic><topic>Cell Proliferation</topic><topic>Cell surface</topic><topic>Cytoplasm</topic><topic>Cytotoxicity</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Foxp3 protein</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Immunology</topic><topic>Interleukin 4</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Retina</topic><topic>Retinal Neoplasms - immunology</topic><topic>Retinal Neoplasms - metabolism</topic><topic>Retinal Neoplasms - pathology</topic><topic>Retinoblastoma</topic><topic>Retinoblastoma - immunology</topic><topic>Retinoblastoma - metabolism</topic><topic>Retinoblastoma - pathology</topic><topic>Retinoblastoma Protein - genetics</topic><topic>Retinoblastoma Protein - metabolism</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>TLR4 protein</topic><topic>Toll-like receptors</topic><topic>Transforming growth factor-b</topic><topic>Tumor Cells, Cultured</topic><topic>Tumor Microenvironment - immunology</topic><topic>Tumors</topic><topic>Twist protein</topic><topic>Twist-Related Protein 1 - genetics</topic><topic>Twist-Related Protein 1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Ruishi</creatorcontrib><creatorcontrib>Song, Yan-Nan</creatorcontrib><creatorcontrib>Duo, Xiaoyan</creatorcontrib><creatorcontrib>Guo, Zhihong</creatorcontrib><creatorcontrib>Sun, Yanhua</creatorcontrib><creatorcontrib>Zhang, Zhixiong</creatorcontrib><creatorcontrib>Lu, Yongtian</creatorcontrib><creatorcontrib>Miao, Beiping</creatorcontrib><creatorcontrib>Yang, Ping-Chang</creatorcontrib><creatorcontrib>Nie, Guohui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer Immunology, Immunotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Ruishi</au><au>Song, Yan-Nan</au><au>Duo, Xiaoyan</au><au>Guo, Zhihong</au><au>Sun, Yanhua</au><au>Zhang, Zhixiong</au><au>Lu, Yongtian</au><au>Miao, Beiping</au><au>Yang, Ping-Chang</au><au>Nie, Guohui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinoblastoma cell-derived Twist protein promotes regulatory T cell development</atitle><jtitle>Cancer Immunology, Immunotherapy</jtitle><stitle>Cancer Immunol Immunother</stitle><addtitle>Cancer Immunol Immunother</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>70</volume><issue>4</issue><spage>1037</spage><epage>1048</epage><pages>1037-1048</pages><issn>0340-7004</issn><eissn>1432-0851</eissn><abstract>Background
The development of tumor tissue-infiltrating regulatory T cell (Treg) is incompletely understood. This study investigates the role of retinoblastoma cell (Rbc)-derived Twist‑related protein 1 (Twist) in the Treg development.
Methods
The surgically removed Rb tissues were collected. Rbcs were cultured with CD4
+
T cells to assess the role of Rbc-derived Twist in the Treg generation.
Results
We found that more than 90% Rbcs expressed Twist. Foxp3
+
Tregs were detected in the Rb tissues that were positively correlated with the Twist expression in Rbcs, negatively associated with Rb patient survival and sight survival. Treating Rbcs with hypoxia promoted the Twist expression that could be detected in the cytoplasm, nuclei and on the cell surface. Twist activated CD4
+
T cells by binding the TLR4/myeloid differentiation factor 2 complex and promoted the transforming growth factor-β-inducible early gene 1 product and Foxp3 expression. These Rbc-induced Foxp3
+
Tregs showed immune-suppressive function on CD8
+
T cell proliferation.
Conclusions
Rbcs express Twist, that induces IL-4
+
Foxp3
+
Tregs; the latter can inhibit CD8
+
cytotoxic T cell activities. Therefore, Twist may play an important role in the pathogenesis of Rb.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33108472</pmid><doi>10.1007/s00262-020-02744-z</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-3738-9385</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-7004 |
| ispartof | Cancer Immunology, Immunotherapy, 2021-04, Vol.70 (4), p.1037-1048 |
| issn | 0340-7004 1432-0851 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10992014 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Cancer Research CD4 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell differentiation Cell Proliferation Cell surface Cytoplasm Cytotoxicity Female Follow-Up Studies Foxp3 protein Gene Expression Regulation, Neoplastic Humans Hypoxia Immunology Interleukin 4 Lymphocytes Lymphocytes T Male Medicine Medicine & Public Health Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncology Original Original Article Prognosis Retina Retinal Neoplasms - immunology Retinal Neoplasms - metabolism Retinal Neoplasms - pathology Retinoblastoma Retinoblastoma - immunology Retinoblastoma - metabolism Retinoblastoma - pathology Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism T-Lymphocytes, Regulatory - immunology TLR4 protein Toll-like receptors Transforming growth factor-b Tumor Cells, Cultured Tumor Microenvironment - immunology Tumors Twist protein Twist-Related Protein 1 - genetics Twist-Related Protein 1 - metabolism |
| title | Retinoblastoma cell-derived Twist protein promotes regulatory T cell development |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T08%3A06%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Retinoblastoma%20cell-derived%20Twist%20protein%20promotes%20regulatory%20T%20cell%20development&rft.jtitle=Cancer%20Immunology,%20Immunotherapy&rft.au=Zhang,%20Ruishi&rft.date=2021-04-01&rft.volume=70&rft.issue=4&rft.spage=1037&rft.epage=1048&rft.pages=1037-1048&rft.issn=0340-7004&rft.eissn=1432-0851&rft_id=info:doi/10.1007/s00262-020-02744-z&rft_dat=%3Cproquest_pubme%3E2455171708%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2503048652&rft_id=info:pmid/33108472&rfr_iscdi=true |