Targeting CD73 increases therapeutic response to immunogenic chemotherapy by promoting dendritic cell maturation

The CD39-CD73–adenosinergic pathway converts adenosine triphosphate (ATP) to adenosine for inhibiting anti-tumor immune responses. Therefore, targeting CD73 to reinvigorate anti-tumor immunity is considered the novel cancer immunotherapy to eradicate tumor cells. To fully understand the critical rol...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2023-07, Vol.72 (7), p.2283-2297
Hauptverfasser:	Lin, Yun-Shan, Chiang, Shu-Fen, Chen, Chia-Yi, Hong, Wei-Ze, Chen, Tsung-Wei, Chen, William Tzu-Liang, Ke, Tao-Wei, Yang, Pei-Chen, Liang, Ji-An, Shiau, An‑Cheng, Chao, K. S. Clifford, Huang, Kevin Chih-Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - pathology Adenosine Adenosine triphosphate Adenosine Triphosphate - metabolism Cancer Cancer immunotherapy Cancer Research CD45 antigen CD73 antigen CD8 antigen Cell death Chemotherapy Colonic Neoplasms - drug therapy Colorectal cancer Colorectal carcinoma Dendritic cells Dendritic Cells - metabolism Epithelial cells Humans Immunogenicity Immunology Immunotherapy Infiltration Lung cancer Lung Neoplasms - drug therapy Medical prognosis Medicine Medicine & Public Health Metastases Metastasis Oncology Oxaliplatin Oxaliplatin - therapeutic use Stromal cells Therapeutic targets Tumor cells Tumors
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