Immune evasion in lung metastasis of leiomyosarcoma: upregulation of EPCAM inhibits CD8+ T cell infiltration

Background Leiomyosarcomas are among the most common histological types of soft tissue sarcoma (STS), with no effective treatment available for advanced patients. Lung metastasis, the most common site of distant metastasis, is the primary prognostic factor. We analysed the immune environment targeti...

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Veröffentlicht in:	British journal of cancer 2024-04, Vol.130 (7), p.1083-1095
Hauptverfasser:	Kanahori, Masaya, Shimada, Eijiro, Matsumoto, Yoshihiro, Endo, Makoto, Fujiwara, Toshifumi, Nabeshima, Akira, Hirose, Takeshi, Kawaguchi, Kengo, Oyama, Ryunosuke, Oda, Yoshinao, Nakashima, Yasuharu
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554/1834 631/250/2161 631/67/1798 631/67/322 631/67/580/1884/2323 Biomedical and Life Sciences Biomedicine Cancer Research CD8 antigen CD8-Positive T-Lymphocytes - pathology Cell migration Drug Resistance Epidemiology Epithelial Cell Adhesion Molecule Gene expression Humans Immune Evasion Immunohistochemistry Immunotherapy Leiomyosarcoma - genetics Leiomyosarcoma - pathology Lung cancer Lung Neoplasms - genetics Lungs Lymphocytes T Metastases Metastasis Molecular Medicine Oncology Sarcoma Soft tissue sarcoma Therapeutic targets Up-Regulation
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