Novel method for production and purification of untagged pneumococcal surface protein A from clade 1

Streptococcus pneumoniae can cause diseases with high mortality and morbidity. The licensed vaccines are based on capsular polysaccharides and induce antibodies with low cross reactivity, leading to restricted coverage of serotypes. For surpassing this limitation, new pneumococcal vaccines are neede...

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Veröffentlicht in:	Applied microbiology and biotechnology 2024-12, Vol.108 (1), p.281-281, Article 281
Hauptverfasser:	da Costa Rodrigues, Tasson, Zorzete, Patricia, Miyaji, Eliane Namie, Gonçalves, Viviane Maimoni
Format:	Artikel
Sprache:	eng
Schlagworte:	acetates Acetic acid Amino acids Animals Anion exchange anion exchange chromatography Anion exchanging Antibodies Antibodies, Bacterial Antigen processing Antigens Bacteria Bacterial Proteins - chemistry biomass production Biomedical and Life Sciences Bioreactors Biotechnologically Relevant Enzymes and Proteins Biotechnology Capsular polysaccharides Cation exchange cation exchange chromatography Cation exchanging Chromatography cross reaction detergents E coli Endotoxins Escherichia coli Fermentation Humans Life Sciences Lysis Mice Mice, Inbred BALB C Microbial Genetics and Genomics Microbiology Morbidity mortality plasmids Pneumococcal Vaccines - metabolism Polysaccharides Protein A Protein purification Proteins PspA protein Purification purification methods Saccharides Serotypes Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - genetics Surface protein A surface proteins Vaccines
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