Novel technical developments in mass spectrometry imaging in 2020: A mini review
The applicability of mass spectrometry imaging (MSI) has exponentially increased with the improvement of sample preparation, instrumentation (spatial resolution) and data analysis. The number of MSI publications listed in PubMed continues to grow with 378 published articles in 2020‐2021. Initially,...
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| Veröffentlicht in: | Analytical Science Advances 2021-04, Vol.2 (3-4), p.225-237 |
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| creator | Dilmetz, Brooke A. Lee, Yea‐Rin Condina, Mark R. Briggs, Matthew Young, Clifford Desire, Christopher T. Klingler‐Hoffmann, Manuela Hoffmann, Peter |
| description | The applicability of mass spectrometry imaging (MSI) has exponentially increased with the improvement of sample preparation, instrumentation (spatial resolution) and data analysis. The number of MSI publications listed in PubMed continues to grow with 378 published articles in 2020‐2021. Initially, MSI was just sensitive enough to identify molecular features correlating with distinct tissue regions, similar to the resolution achieved by visual inspection after standard immunohistochemical staining. Although the spatial resolution was limited compared with other imaging modalities, the molecular intensity mapping added a new exciting capability. Over the past decade, significant improvements in every step of the workflow and most importantly in instrumentation were made, which now enables the molecular analysis at a cellular and even subcellular level. Here, we summarize the latest developments in MSI, with a focus on the latest approaches for tissue‐based imaging described in 2020. |
| doi_str_mv | 10.1002/ansa.202000176 |
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The number of MSI publications listed in PubMed continues to grow with 378 published articles in 2020‐2021. Initially, MSI was just sensitive enough to identify molecular features correlating with distinct tissue regions, similar to the resolution achieved by visual inspection after standard immunohistochemical staining. Although the spatial resolution was limited compared with other imaging modalities, the molecular intensity mapping added a new exciting capability. Over the past decade, significant improvements in every step of the workflow and most importantly in instrumentation were made, which now enables the molecular analysis at a cellular and even subcellular level. Here, we summarize the latest developments in MSI, with a focus on the latest approaches for tissue‐based imaging described in 2020.</description><identifier>ISSN: 2628-5452</identifier><identifier>EISSN: 2628-5452</identifier><identifier>DOI: 10.1002/ansa.202000176</identifier><identifier>PMID: 38716449</identifier><language>eng</language><publisher>Germany: John Wiley & Sons, Inc</publisher><subject>Ablation ; Alzheimer's disease ; Antigens ; Cellulose ; Data analysis ; Enzymes ; Ethanol ; formalin‐fixed paraffin‐embedded ; Immunohistochemistry ; Information management ; Ions ; Lasers ; Lipids ; MALDI ; Mass spectrometry ; mass spectrometry imaging ; Metabolites ; Mini Review ; Morphology ; Peptides ; Proteins ; Quality control ; Reproducibility ; Scientific imaging ; Spectrum analysis ; workflows</subject><ispartof>Analytical Science Advances, 2021-04, Vol.2 (3-4), p.225-237</ispartof><rights>2021 The Authors. published by Wiley‐VCH GmbH</rights><rights>2021 The Authors. Analytical Science Advances published by Wiley‐VCH GmbH.</rights><rights>COPYRIGHT 2021 John Wiley & Sons, Inc.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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The number of MSI publications listed in PubMed continues to grow with 378 published articles in 2020‐2021. Initially, MSI was just sensitive enough to identify molecular features correlating with distinct tissue regions, similar to the resolution achieved by visual inspection after standard immunohistochemical staining. Although the spatial resolution was limited compared with other imaging modalities, the molecular intensity mapping added a new exciting capability. Over the past decade, significant improvements in every step of the workflow and most importantly in instrumentation were made, which now enables the molecular analysis at a cellular and even subcellular level. 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| subjects | Ablation Alzheimer's disease Antigens Cellulose Data analysis Enzymes Ethanol formalin‐fixed paraffin‐embedded Immunohistochemistry Information management Ions Lasers Lipids MALDI Mass spectrometry mass spectrometry imaging Metabolites Mini Review Morphology Peptides Proteins Quality control Reproducibility Scientific imaging Spectrum analysis workflows |
| title | Novel technical developments in mass spectrometry imaging in 2020: A mini review |
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