Influence of nonalcoholic fatty liver disease on response to antiviral treatment in patients with chronic hepatitis B: A meta-analysis
Although hepatitis B virus infection is the leading cause of chronic liver injury globally, nonalcoholic fatty liver disease (NAFLD) is gradually gaining attention as another major chronic liver disease. The number of patients having chronic hepatitis B (CHB) with concomitant hepatic steatosis has i...
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| Veröffentlicht in: | World journal of hepatology 2024-03, Vol.16 (3), p.465-476 |
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| creator | Liu, Shi-Yi Wang, Dian Liu, Jing Yang, Lu-Ping Chen, Gong-Ying |
| description | Although hepatitis B virus infection is the leading cause of chronic liver injury globally, nonalcoholic fatty liver disease (NAFLD) is gradually gaining attention as another major chronic liver disease. The number of patients having chronic hepatitis B (CHB) with concomitant hepatic steatosis has increased.
To analyze the effect of NAFLD on the response to antiviral treatment in patients with CHB.
Relevant English studies were systematically searched across PubMed, EMBASE, Web of Science, and Cochrane Library until October 2023. Studies in which the treatment outcomes were compared between patients with CHB only and those with CHB and hepatic steatosis were included.
Of the 2502 retrieved studies, 11 articles were finally included. Biochemical response until 48 wk (OR = 0.87, 95%CI: 0.50-1.53,
= 0.000) and 96 wk (OR = 0.35, 95%CI: 0.24-0.53,
= 0.24) and virological response until 96 wk (OR = 0.80, 95%CI: 0.43-1.49,
= 0.097) were lower in patients with hepatic steatosis than in patients with CHB alone.
Hepatic steatosis lowers the biochemical response to antiviral treatment in patients with CHB. |
| doi_str_mv | 10.4254/wjh.v16.i3.465 |
| format | Article |
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To analyze the effect of NAFLD on the response to antiviral treatment in patients with CHB.
Relevant English studies were systematically searched across PubMed, EMBASE, Web of Science, and Cochrane Library until October 2023. Studies in which the treatment outcomes were compared between patients with CHB only and those with CHB and hepatic steatosis were included.
Of the 2502 retrieved studies, 11 articles were finally included. Biochemical response until 48 wk (OR = 0.87, 95%CI: 0.50-1.53,
= 0.000) and 96 wk (OR = 0.35, 95%CI: 0.24-0.53,
= 0.24) and virological response until 96 wk (OR = 0.80, 95%CI: 0.43-1.49,
= 0.097) were lower in patients with hepatic steatosis than in patients with CHB alone.
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To analyze the effect of NAFLD on the response to antiviral treatment in patients with CHB.
Relevant English studies were systematically searched across PubMed, EMBASE, Web of Science, and Cochrane Library until October 2023. Studies in which the treatment outcomes were compared between patients with CHB only and those with CHB and hepatic steatosis were included.
Of the 2502 retrieved studies, 11 articles were finally included. Biochemical response until 48 wk (OR = 0.87, 95%CI: 0.50-1.53,
= 0.000) and 96 wk (OR = 0.35, 95%CI: 0.24-0.53,
= 0.24) and virological response until 96 wk (OR = 0.80, 95%CI: 0.43-1.49,
= 0.097) were lower in patients with hepatic steatosis than in patients with CHB alone.
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To analyze the effect of NAFLD on the response to antiviral treatment in patients with CHB.
Relevant English studies were systematically searched across PubMed, EMBASE, Web of Science, and Cochrane Library until October 2023. Studies in which the treatment outcomes were compared between patients with CHB only and those with CHB and hepatic steatosis were included.
Of the 2502 retrieved studies, 11 articles were finally included. Biochemical response until 48 wk (OR = 0.87, 95%CI: 0.50-1.53,
= 0.000) and 96 wk (OR = 0.35, 95%CI: 0.24-0.53,
= 0.24) and virological response until 96 wk (OR = 0.80, 95%CI: 0.43-1.49,
= 0.097) were lower in patients with hepatic steatosis than in patients with CHB alone.
Hepatic steatosis lowers the biochemical response to antiviral treatment in patients with CHB.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>38577526</pmid><doi>10.4254/wjh.v16.i3.465</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1948-5182 |
| ispartof | World journal of hepatology, 2024-03, Vol.16 (3), p.465-476 |
| issn | 1948-5182 1948-5182 |
| language | eng |
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| source | Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Meta-Analysis |
| title | Influence of nonalcoholic fatty liver disease on response to antiviral treatment in patients with chronic hepatitis B: A meta-analysis |
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