Normal and Aberrant Methyltransferase Activities Give Insights into the Final Steps of Dynemicin A Biosynthesis

The naturally occurring enediynes are notable for their complex structures, potent DNA cleaving ability, and emerging usefulness in cancer chemotherapy. They can be classified into three distinct structural families, but all are thought to originate from a common linear C15-heptaene. Dynemicin A (DY...

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Veröffentlicht in:	Journal of the American Chemical Society 2023-06, Vol.145 (23), p.12935-12947
Hauptverfasser:	Pal, Paramita, Wessely, Serena M. L., Townsend, Craig A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthraquinones - chemistry Antibiotics, Antineoplastic - chemistry DNA Enediynes - chemistry Humans
Online-Zugang:	Volltext
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