Clinical implications of T cell exhaustion for cancer immunotherapy

Immunotherapy has been a remarkable clinical advancement in the treatment of cancer. T cells are pivotal to the efficacy of current cancer immunotherapies, including immune-checkpoint inhibitors and adoptive cell therapies. However, cancer is associated with T cell exhaustion, a hypofunctional state...

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Veröffentlicht in:	Nature reviews. Clinical oncology 2022-12, Vol.19 (12), p.775-790
Hauptverfasser:	Chow, Andrew, Perica, Karlo, Klebanoff, Christopher A., Wolchok, Jedd D.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/251 692/4028/67/580/1884 Antigens Cancer Cancer immunotherapy Chronic exposure Clinical outcomes Epigenetics Humans Immune Checkpoint Inhibitors Immunotherapy Immunotherapy, Adoptive Lymphocytes Lymphocytes T Medicine Medicine & Public Health Microenvironments Neoplasms Oncology Review Article Reviews T-Lymphocytes Tumor Microenvironment Tumors
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