Primary cutaneous apocrine carcinoma: A challenging case report
Primary cutaneous apocrine carcinomas of the axilla represents an extremely rare entity, with
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| Veröffentlicht in: | International journal of surgery case reports 2024-04, Vol.117, p.109513, Article 109513 |
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| container_title | International journal of surgery case reports |
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| creator | Khessairi, Nayssem Fertani, Yasmine Sakhri, Saida Abbess, Imen Zemni, Ines Dhiab, Tarek Ben |
| description | Primary cutaneous apocrine carcinomas of the axilla represents an extremely rare entity, with |
| doi_str_mv | 10.1016/j.ijscr.2024.109513 |
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| fullrecord | <record><control><sourceid>elsevier_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10972830</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2210261224002943</els_id><sourcerecordid>S2210261224002943</sourcerecordid><originalsourceid>FETCH-LOGICAL-c377t-29f65cff737417097dc11553accf3be57bc2a4367590c0fbc3694bb18d97ae803</originalsourceid><addsrcrecordid>eNp9kF1LwzAUhoMobsz9AkH6Bzrz0TatIGMMv2CgF3od0tPTLaVLS9IN_Pd2Vse8MTcJ55z3fU8eQq4ZnTHKkttqZioPbsYpj_pKFjNxRsacMxryhPHzk_eITL2vaH8ETxPOL8lIpDFLoyQak_mbM1vtPgPYddpis_OBbhtwxmIA2oGxzVbfBYsANrqu0a6NXfcNj4HDtnHdFbkode1x-nNPyMfjw_vyOVy9Pr0sF6sQhJRdyLMyiaEspZARkzSTBTAWx0IDlCLHWObAdSQSGWcUaJmDSLIoz1laZFJjSsWEzAffdpdvsQC0ndO1aoftVaON-tuxZqPWzV71bCRPxcFBDA7gGu8dlkcxo-rAVFXqm6k6MFUD0151c5p71PwS7AfuhwHsf7836JQHgxawMA6hU0Vj_g34AvHiic8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Primary cutaneous apocrine carcinoma: A challenging case report</title><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Khessairi, Nayssem ; Fertani, Yasmine ; Sakhri, Saida ; Abbess, Imen ; Zemni, Ines ; Dhiab, Tarek Ben</creator><creatorcontrib>Khessairi, Nayssem ; Fertani, Yasmine ; Sakhri, Saida ; Abbess, Imen ; Zemni, Ines ; Dhiab, Tarek Ben</creatorcontrib><description>Primary cutaneous apocrine carcinomas of the axilla represents an extremely rare entity, with <200 cases reported in the literature. It can be challenging, even almost impossible, to distinguish histologically from metastases of breast origin. We herein present the first case of an axillary cutaneous apocrine adenocarcinoma followed and treated in our institute.
A 58-year-old man with a history of myopathy, presented for a right axillary swelling. Physical examination revealed the presence of a 10 cm right axillary mass, no palpable adenopathy, and bilateral gynecomastia. A biopsy of the mass was performed, showing a pattern consistent with a secondary localization of mammary neoplasia. Breast and distant radiological examinations were negative. The tumor markers' levels were not raised. Therefore, the patient underwent surgery with a large excision, a right axillary lymph node dissection, covered with a pedicled pectoralis major flap. Histological and immunohistochemical examinations showed a high expression of CK7 with a negative expression of TTF1, RH, PSA, and CK20. The diagnosis of an apocrine adenocarcinoma from cutaneous origin was confirmed.
Primary cutaneous apocrine carcinomas are a group of uncommon malignant adnexal tumors, whose diagnosis is almost impossible to confirm preoperatively. Wide, local excision with clear margins, with or without lymph node dissection is the standard treatment.
This case illustrates the importance of clinico-pathological correlation of skin cancers, especially apocrine ones. Clinical particularity and careful histological analysis are used to guide the diagnostic approach.
•Cutaneous apocrine carcinoma is an extremely rare entity.•this type of neoplasm occurs mainly in areas where apocrine gland density is high, particularly in the axilla.•It is challenging to differentiate primary cutaneous apocrine carcinoma from other tumor types.</description><identifier>ISSN: 2210-2612</identifier><identifier>EISSN: 2210-2612</identifier><identifier>DOI: 10.1016/j.ijscr.2024.109513</identifier><identifier>PMID: 38518464</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adnexal neoplasm ; Apocrine adenocarcinoma ; Axillary mass ; Case Report ; Sweat glands</subject><ispartof>International journal of surgery case reports, 2024-04, Vol.117, p.109513, Article 109513</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><rights>2024 The Authors. Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c377t-29f65cff737417097dc11553accf3be57bc2a4367590c0fbc3694bb18d97ae803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10972830/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S2210261224002943$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,3537,27901,27902,53766,53768,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38518464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khessairi, Nayssem</creatorcontrib><creatorcontrib>Fertani, Yasmine</creatorcontrib><creatorcontrib>Sakhri, Saida</creatorcontrib><creatorcontrib>Abbess, Imen</creatorcontrib><creatorcontrib>Zemni, Ines</creatorcontrib><creatorcontrib>Dhiab, Tarek Ben</creatorcontrib><title>Primary cutaneous apocrine carcinoma: A challenging case report</title><title>International journal of surgery case reports</title><addtitle>Int J Surg Case Rep</addtitle><description>Primary cutaneous apocrine carcinomas of the axilla represents an extremely rare entity, with <200 cases reported in the literature. It can be challenging, even almost impossible, to distinguish histologically from metastases of breast origin. We herein present the first case of an axillary cutaneous apocrine adenocarcinoma followed and treated in our institute.
A 58-year-old man with a history of myopathy, presented for a right axillary swelling. Physical examination revealed the presence of a 10 cm right axillary mass, no palpable adenopathy, and bilateral gynecomastia. A biopsy of the mass was performed, showing a pattern consistent with a secondary localization of mammary neoplasia. Breast and distant radiological examinations were negative. The tumor markers' levels were not raised. Therefore, the patient underwent surgery with a large excision, a right axillary lymph node dissection, covered with a pedicled pectoralis major flap. Histological and immunohistochemical examinations showed a high expression of CK7 with a negative expression of TTF1, RH, PSA, and CK20. The diagnosis of an apocrine adenocarcinoma from cutaneous origin was confirmed.
Primary cutaneous apocrine carcinomas are a group of uncommon malignant adnexal tumors, whose diagnosis is almost impossible to confirm preoperatively. Wide, local excision with clear margins, with or without lymph node dissection is the standard treatment.
This case illustrates the importance of clinico-pathological correlation of skin cancers, especially apocrine ones. Clinical particularity and careful histological analysis are used to guide the diagnostic approach.
•Cutaneous apocrine carcinoma is an extremely rare entity.•this type of neoplasm occurs mainly in areas where apocrine gland density is high, particularly in the axilla.•It is challenging to differentiate primary cutaneous apocrine carcinoma from other tumor types.</description><subject>Adnexal neoplasm</subject><subject>Apocrine adenocarcinoma</subject><subject>Axillary mass</subject><subject>Case Report</subject><subject>Sweat glands</subject><issn>2210-2612</issn><issn>2210-2612</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kF1LwzAUhoMobsz9AkH6Bzrz0TatIGMMv2CgF3od0tPTLaVLS9IN_Pd2Vse8MTcJ55z3fU8eQq4ZnTHKkttqZioPbsYpj_pKFjNxRsacMxryhPHzk_eITL2vaH8ETxPOL8lIpDFLoyQak_mbM1vtPgPYddpis_OBbhtwxmIA2oGxzVbfBYsANrqu0a6NXfcNj4HDtnHdFbkode1x-nNPyMfjw_vyOVy9Pr0sF6sQhJRdyLMyiaEspZARkzSTBTAWx0IDlCLHWObAdSQSGWcUaJmDSLIoz1laZFJjSsWEzAffdpdvsQC0ndO1aoftVaON-tuxZqPWzV71bCRPxcFBDA7gGu8dlkcxo-rAVFXqm6k6MFUD0151c5p71PwS7AfuhwHsf7836JQHgxawMA6hU0Vj_g34AvHiic8</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Khessairi, Nayssem</creator><creator>Fertani, Yasmine</creator><creator>Sakhri, Saida</creator><creator>Abbess, Imen</creator><creator>Zemni, Ines</creator><creator>Dhiab, Tarek Ben</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20240401</creationdate><title>Primary cutaneous apocrine carcinoma: A challenging case report</title><author>Khessairi, Nayssem ; Fertani, Yasmine ; Sakhri, Saida ; Abbess, Imen ; Zemni, Ines ; Dhiab, Tarek Ben</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-29f65cff737417097dc11553accf3be57bc2a4367590c0fbc3694bb18d97ae803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adnexal neoplasm</topic><topic>Apocrine adenocarcinoma</topic><topic>Axillary mass</topic><topic>Case Report</topic><topic>Sweat glands</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khessairi, Nayssem</creatorcontrib><creatorcontrib>Fertani, Yasmine</creatorcontrib><creatorcontrib>Sakhri, Saida</creatorcontrib><creatorcontrib>Abbess, Imen</creatorcontrib><creatorcontrib>Zemni, Ines</creatorcontrib><creatorcontrib>Dhiab, Tarek Ben</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of surgery case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khessairi, Nayssem</au><au>Fertani, Yasmine</au><au>Sakhri, Saida</au><au>Abbess, Imen</au><au>Zemni, Ines</au><au>Dhiab, Tarek Ben</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary cutaneous apocrine carcinoma: A challenging case report</atitle><jtitle>International journal of surgery case reports</jtitle><addtitle>Int J Surg Case Rep</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>117</volume><spage>109513</spage><pages>109513-</pages><artnum>109513</artnum><issn>2210-2612</issn><eissn>2210-2612</eissn><abstract>Primary cutaneous apocrine carcinomas of the axilla represents an extremely rare entity, with <200 cases reported in the literature. It can be challenging, even almost impossible, to distinguish histologically from metastases of breast origin. We herein present the first case of an axillary cutaneous apocrine adenocarcinoma followed and treated in our institute.
A 58-year-old man with a history of myopathy, presented for a right axillary swelling. Physical examination revealed the presence of a 10 cm right axillary mass, no palpable adenopathy, and bilateral gynecomastia. A biopsy of the mass was performed, showing a pattern consistent with a secondary localization of mammary neoplasia. Breast and distant radiological examinations were negative. The tumor markers' levels were not raised. Therefore, the patient underwent surgery with a large excision, a right axillary lymph node dissection, covered with a pedicled pectoralis major flap. Histological and immunohistochemical examinations showed a high expression of CK7 with a negative expression of TTF1, RH, PSA, and CK20. The diagnosis of an apocrine adenocarcinoma from cutaneous origin was confirmed.
Primary cutaneous apocrine carcinomas are a group of uncommon malignant adnexal tumors, whose diagnosis is almost impossible to confirm preoperatively. Wide, local excision with clear margins, with or without lymph node dissection is the standard treatment.
This case illustrates the importance of clinico-pathological correlation of skin cancers, especially apocrine ones. Clinical particularity and careful histological analysis are used to guide the diagnostic approach.
•Cutaneous apocrine carcinoma is an extremely rare entity.•this type of neoplasm occurs mainly in areas where apocrine gland density is high, particularly in the axilla.•It is challenging to differentiate primary cutaneous apocrine carcinoma from other tumor types.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>38518464</pmid><doi>10.1016/j.ijscr.2024.109513</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adnexal neoplasm Apocrine adenocarcinoma Axillary mass Case Report Sweat glands |
| title | Primary cutaneous apocrine carcinoma: A challenging case report |
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