Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling

DNA methyltransferase inhibitor (DNMTi) efficacy in solid tumors is limited. Colon cancer cells exposed to DNMTi accumulate lysine-27 trimethylation on histone H3 (H3K27me3). We propose this Enhancer of Zeste Homolog 2 (EZH2)-dependent repressive modification limits DNMTi efficacy. Here, we show tha...

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Veröffentlicht in:	Science advances 2024-03, Vol.10 (13), p.eadk4423-eadk4423
Hauptverfasser:	Chomiak, Alison A, Tiedemann, Rochelle L, Liu, Yanqing, Kong, Xiangqian, Cui, Ying, Wiseman, Ashley K, Thurlow, Kate E, Cornett, Evan M, Topper, Michael J, Baylin, Stephen B, Rothbart, Scott B
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedicine and Life Sciences Cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors Histones - metabolism Humans Methylation Molecular Biology SciAdv r-articles Signal Transduction Transcription Factor AP-1 - metabolism
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