Ictal Bradycardia and Asystole in Sleep-Related Hypermotor Epilepsy: A Study of 200 Patients
: Ictal bradycardia (IB) and asystole (IA) represent a rare but potentially harmful feature of epileptic seizures. The aim of this study was to study IB/IA in patients with sleep-related hypermotor epilepsy (SHE). : We retrospectively included cases with video-EEG-confirmed SHE who attended our Inst...
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| Veröffentlicht in: | Journal of clinical medicine 2024-03, Vol.13 (6), p.1767 |
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| creator | Muccioli, Lorenzo Bruschi, Giulia Ferri, Lorenzo Scarabello, Anna Taruffi, Lisa Di Vito, Lidia Mostacci, Barbara Provini, Federica Calandra-Buonaura, Giovanna Tinuper, Paolo Licchetta, Laura Bisulli, Francesca |
| description | : Ictal bradycardia (IB) and asystole (IA) represent a rare but potentially harmful feature of epileptic seizures. The aim of this study was to study IB/IA in patients with sleep-related hypermotor epilepsy (SHE).
: We retrospectively included cases with video-EEG-confirmed SHE who attended our Institute up to January 2021. We reviewed the ictal polysomnography recordings focusing on ECG and identified cases with IB (R-R interval ≥ 2 s or a ≥10% decrease of baseline heart rate) and IA (R-R interval ≥ 4 s).
: We included 200 patients (123 males, 61.5%), with a mean age of 42 ± 16 years. Twenty patients (20%) had focal cortical dysplasia (FCD) on brain MRI. Eighteen (out of 104 tested, 17.3%) carried pathogenic variants (mTOR pathway,
= 10, nAchR subunits,
= 4, KCNT1,
= 4). We identified IB/IA in four cases (2%): three had IA (mean 10 s) and one had IB. Three patients had FCD (left fronto-insular region, left amygdala, right mid-temporal gyrus) and two had pathogenic variants in
; both features were more prevalent in patients with IB/IA than those without (
= 0.003 and
= 0.037, respectively).
: We identified IB/IA in 2% of patients with SHE and showed that this subgroup more frequently had FCD on brain MRI and pathogenic variants in genes related to the mTOR pathway. |
| doi_str_mv | 10.3390/jcm13061767 |
| format | Article |
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: We retrospectively included cases with video-EEG-confirmed SHE who attended our Institute up to January 2021. We reviewed the ictal polysomnography recordings focusing on ECG and identified cases with IB (R-R interval ≥ 2 s or a ≥10% decrease of baseline heart rate) and IA (R-R interval ≥ 4 s).
: We included 200 patients (123 males, 61.5%), with a mean age of 42 ± 16 years. Twenty patients (20%) had focal cortical dysplasia (FCD) on brain MRI. Eighteen (out of 104 tested, 17.3%) carried pathogenic variants (mTOR pathway,
= 10, nAchR subunits,
= 4, KCNT1,
= 4). We identified IB/IA in four cases (2%): three had IA (mean 10 s) and one had IB. Three patients had FCD (left fronto-insular region, left amygdala, right mid-temporal gyrus) and two had pathogenic variants in
; both features were more prevalent in patients with IB/IA than those without (
= 0.003 and
= 0.037, respectively).
: We identified IB/IA in 2% of patients with SHE and showed that this subgroup more frequently had FCD on brain MRI and pathogenic variants in genes related to the mTOR pathway.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm13061767</identifier><identifier>PMID: 38541990</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Bradycardia ; Cardiac arrhythmia ; Complications and side effects ; Convulsions & seizures ; Diagnosis ; Electrocardiogram ; Electrocardiography ; Epilepsy ; Etiology ; Heart beat ; Heart rate ; Lamotrigine ; Medical research ; Medicine, Experimental ; Patients ; Risk factors ; Seizures (Medicine) ; Sleep ; Surgery</subject><ispartof>Journal of clinical medicine, 2024-03, Vol.13 (6), p.1767</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c435t-d32416ff59e072fd6b63518c21bf1b9b21ec6a7a91631db23f598ef3113c567c3</cites><orcidid>0000-0001-9063-2658 ; 0000-0001-6827-0099 ; 0000-0002-0266-6776 ; 0000-0002-1109-7296</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10971271/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10971271/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38541990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muccioli, Lorenzo</creatorcontrib><creatorcontrib>Bruschi, Giulia</creatorcontrib><creatorcontrib>Ferri, Lorenzo</creatorcontrib><creatorcontrib>Scarabello, Anna</creatorcontrib><creatorcontrib>Taruffi, Lisa</creatorcontrib><creatorcontrib>Di Vito, Lidia</creatorcontrib><creatorcontrib>Mostacci, Barbara</creatorcontrib><creatorcontrib>Provini, Federica</creatorcontrib><creatorcontrib>Calandra-Buonaura, Giovanna</creatorcontrib><creatorcontrib>Tinuper, Paolo</creatorcontrib><creatorcontrib>Licchetta, Laura</creatorcontrib><creatorcontrib>Bisulli, Francesca</creatorcontrib><title>Ictal Bradycardia and Asystole in Sleep-Related Hypermotor Epilepsy: A Study of 200 Patients</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>: Ictal bradycardia (IB) and asystole (IA) represent a rare but potentially harmful feature of epileptic seizures. The aim of this study was to study IB/IA in patients with sleep-related hypermotor epilepsy (SHE).
: We retrospectively included cases with video-EEG-confirmed SHE who attended our Institute up to January 2021. We reviewed the ictal polysomnography recordings focusing on ECG and identified cases with IB (R-R interval ≥ 2 s or a ≥10% decrease of baseline heart rate) and IA (R-R interval ≥ 4 s).
: We included 200 patients (123 males, 61.5%), with a mean age of 42 ± 16 years. Twenty patients (20%) had focal cortical dysplasia (FCD) on brain MRI. Eighteen (out of 104 tested, 17.3%) carried pathogenic variants (mTOR pathway,
= 10, nAchR subunits,
= 4, KCNT1,
= 4). We identified IB/IA in four cases (2%): three had IA (mean 10 s) and one had IB. Three patients had FCD (left fronto-insular region, left amygdala, right mid-temporal gyrus) and two had pathogenic variants in
; both features were more prevalent in patients with IB/IA than those without (
= 0.003 and
= 0.037, respectively).
: We identified IB/IA in 2% of patients with SHE and showed that this subgroup more frequently had FCD on brain MRI and pathogenic variants in genes related to the mTOR pathway.</description><subject>Bradycardia</subject><subject>Cardiac arrhythmia</subject><subject>Complications and side effects</subject><subject>Convulsions & seizures</subject><subject>Diagnosis</subject><subject>Electrocardiogram</subject><subject>Electrocardiography</subject><subject>Epilepsy</subject><subject>Etiology</subject><subject>Heart beat</subject><subject>Heart rate</subject><subject>Lamotrigine</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Patients</subject><subject>Risk factors</subject><subject>Seizures (Medicine)</subject><subject>Sleep</subject><subject>Surgery</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkttrFTEQhxdRbKl98l0CvgiyNZPs5uKLHEu1hYJi9U0I2VxqDtnNmuwR9r83pbWeipmHDMw3v2EuTfMc8AmlEr_ZmhEoZsAZf9QcEsx5i6mgj_f8g-a4lC2uT4iOAH_aHFDRdyAlPmy-X5hFR_Q-a7sanW3QSE8WbcpalhQdChO6is7N7RcX9eIsOl9nl8e0pIzO5hDdXNa3aIOulp1dUfKIYIw-6yW4aSnPmidex-KO7_6j5tuHs6-n5-3lp48Xp5vL1nS0X1pLSQfM-146zIm3bGC0B2EIDB4GORBwhmmuJTAKdiC0ksJ5CkBNz7ihR827W915N4zOmlo766jmHEadV5V0UA8jU_ihrtMvBVhyIByqwqs7hZx-7lxZ1BiKcTHqyaVdURRDh7EE3lX05T_oNu3yVPurFCZMkl6yv9S1jk6Fyada2NyIqg0XgnRCSlGpk_9Q1awbg0mT83XCDxNe3yaYnErJzt83CVjdHITaO4hKv9ifyz37Z_30Nw5argI</recordid><startdate>20240319</startdate><enddate>20240319</enddate><creator>Muccioli, Lorenzo</creator><creator>Bruschi, Giulia</creator><creator>Ferri, Lorenzo</creator><creator>Scarabello, Anna</creator><creator>Taruffi, Lisa</creator><creator>Di Vito, Lidia</creator><creator>Mostacci, Barbara</creator><creator>Provini, Federica</creator><creator>Calandra-Buonaura, Giovanna</creator><creator>Tinuper, Paolo</creator><creator>Licchetta, Laura</creator><creator>Bisulli, Francesca</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9063-2658</orcidid><orcidid>https://orcid.org/0000-0001-6827-0099</orcidid><orcidid>https://orcid.org/0000-0002-0266-6776</orcidid><orcidid>https://orcid.org/0000-0002-1109-7296</orcidid></search><sort><creationdate>20240319</creationdate><title>Ictal Bradycardia and Asystole in Sleep-Related Hypermotor Epilepsy: A Study of 200 Patients</title><author>Muccioli, Lorenzo ; Bruschi, Giulia ; Ferri, Lorenzo ; Scarabello, Anna ; Taruffi, Lisa ; Di Vito, Lidia ; Mostacci, Barbara ; Provini, Federica ; Calandra-Buonaura, Giovanna ; Tinuper, Paolo ; Licchetta, Laura ; Bisulli, Francesca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-d32416ff59e072fd6b63518c21bf1b9b21ec6a7a91631db23f598ef3113c567c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Bradycardia</topic><topic>Cardiac arrhythmia</topic><topic>Complications and side effects</topic><topic>Convulsions & seizures</topic><topic>Diagnosis</topic><topic>Electrocardiogram</topic><topic>Electrocardiography</topic><topic>Epilepsy</topic><topic>Etiology</topic><topic>Heart beat</topic><topic>Heart rate</topic><topic>Lamotrigine</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Patients</topic><topic>Risk factors</topic><topic>Seizures (Medicine)</topic><topic>Sleep</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muccioli, Lorenzo</creatorcontrib><creatorcontrib>Bruschi, Giulia</creatorcontrib><creatorcontrib>Ferri, Lorenzo</creatorcontrib><creatorcontrib>Scarabello, Anna</creatorcontrib><creatorcontrib>Taruffi, Lisa</creatorcontrib><creatorcontrib>Di Vito, Lidia</creatorcontrib><creatorcontrib>Mostacci, Barbara</creatorcontrib><creatorcontrib>Provini, Federica</creatorcontrib><creatorcontrib>Calandra-Buonaura, Giovanna</creatorcontrib><creatorcontrib>Tinuper, Paolo</creatorcontrib><creatorcontrib>Licchetta, Laura</creatorcontrib><creatorcontrib>Bisulli, Francesca</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muccioli, Lorenzo</au><au>Bruschi, Giulia</au><au>Ferri, Lorenzo</au><au>Scarabello, Anna</au><au>Taruffi, Lisa</au><au>Di Vito, Lidia</au><au>Mostacci, Barbara</au><au>Provini, Federica</au><au>Calandra-Buonaura, Giovanna</au><au>Tinuper, Paolo</au><au>Licchetta, Laura</au><au>Bisulli, Francesca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ictal Bradycardia and Asystole in Sleep-Related Hypermotor Epilepsy: A Study of 200 Patients</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2024-03-19</date><risdate>2024</risdate><volume>13</volume><issue>6</issue><spage>1767</spage><pages>1767-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>: Ictal bradycardia (IB) and asystole (IA) represent a rare but potentially harmful feature of epileptic seizures. The aim of this study was to study IB/IA in patients with sleep-related hypermotor epilepsy (SHE).
: We retrospectively included cases with video-EEG-confirmed SHE who attended our Institute up to January 2021. We reviewed the ictal polysomnography recordings focusing on ECG and identified cases with IB (R-R interval ≥ 2 s or a ≥10% decrease of baseline heart rate) and IA (R-R interval ≥ 4 s).
: We included 200 patients (123 males, 61.5%), with a mean age of 42 ± 16 years. Twenty patients (20%) had focal cortical dysplasia (FCD) on brain MRI. Eighteen (out of 104 tested, 17.3%) carried pathogenic variants (mTOR pathway,
= 10, nAchR subunits,
= 4, KCNT1,
= 4). We identified IB/IA in four cases (2%): three had IA (mean 10 s) and one had IB. Three patients had FCD (left fronto-insular region, left amygdala, right mid-temporal gyrus) and two had pathogenic variants in
; both features were more prevalent in patients with IB/IA than those without (
= 0.003 and
= 0.037, respectively).
: We identified IB/IA in 2% of patients with SHE and showed that this subgroup more frequently had FCD on brain MRI and pathogenic variants in genes related to the mTOR pathway.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38541990</pmid><doi>10.3390/jcm13061767</doi><orcidid>https://orcid.org/0000-0001-9063-2658</orcidid><orcidid>https://orcid.org/0000-0001-6827-0099</orcidid><orcidid>https://orcid.org/0000-0002-0266-6776</orcidid><orcidid>https://orcid.org/0000-0002-1109-7296</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Bradycardia Cardiac arrhythmia Complications and side effects Convulsions & seizures Diagnosis Electrocardiogram Electrocardiography Epilepsy Etiology Heart beat Heart rate Lamotrigine Medical research Medicine, Experimental Patients Risk factors Seizures (Medicine) Sleep Surgery |
| title | Ictal Bradycardia and Asystole in Sleep-Related Hypermotor Epilepsy: A Study of 200 Patients |
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