Nephrectomy with Autotransplantation-A Key Treasure
Nephrectomy with autotransplantation (NAT) has been performed as an alternative treatment for complex renovascular lesions, intricate ureteral strictures and nephron-sparing surgery in complex renal tumors. : A retrospective observational study was conducted including patients who underwent a NAT fr...
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| Veröffentlicht in: | Journal of clinical medicine 2024-03, Vol.13 (6), p.1641 |
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| creator | Mesquita, Sofia Marques-Monteiro, Miguel Madanelo, Mariana Rocha, Maria Alexandra Vinagre, Nuno Fraga, Avelino Cavadas, Vítor Machado, Rui Silva-Ramos, Miguel |
| description | Nephrectomy with autotransplantation (NAT) has been performed as an alternative treatment for complex renovascular lesions, intricate ureteral strictures and nephron-sparing surgery in complex renal tumors.
: A retrospective observational study was conducted including patients who underwent a NAT from January 2010 to September 2023. Data collected included surgery indications, surgical technique, complications according to Clavien-Dindo classification and mean hospital stay. Descriptive and inferential statistical analysis was performed using IBM
SPSS
Statistics version 28.0.1.0.
A total of 34 consecutive patients underwent 38 NATs at our institution. Surgery indications were complex renovascular conditions in 35 cases (92.1%), of which 24 had renal artery aneurysms, and ureteral injuries in 3 cases (7.9%). Thirty-four kidneys (89.5%) were retrieved through a laparoscopic approach. No significant difference was observed between post- and pre-operative creatinine levels (0.81 vs. 0.72,
= 0.303). Early high-grade complications developed in 12 procedures (31.6%). Median cold ischemia time was significantly longer in patients who developed complications (163.0 vs. 115.0,
= 0.010). The median hospital stay was 10 days (8-13). The median follow-up was 51.5 months.
NAT emerges as a successful therapeutic strategy for a highly select group of patients dealing with intricate ureteral lesions and kidney vascular abnormalities, demonstrating positive outcomes that endure in the long term. |
| doi_str_mv | 10.3390/jcm13061641 |
| format | Article |
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: A retrospective observational study was conducted including patients who underwent a NAT from January 2010 to September 2023. Data collected included surgery indications, surgical technique, complications according to Clavien-Dindo classification and mean hospital stay. Descriptive and inferential statistical analysis was performed using IBM
SPSS
Statistics version 28.0.1.0.
A total of 34 consecutive patients underwent 38 NATs at our institution. Surgery indications were complex renovascular conditions in 35 cases (92.1%), of which 24 had renal artery aneurysms, and ureteral injuries in 3 cases (7.9%). Thirty-four kidneys (89.5%) were retrieved through a laparoscopic approach. No significant difference was observed between post- and pre-operative creatinine levels (0.81 vs. 0.72,
= 0.303). Early high-grade complications developed in 12 procedures (31.6%). Median cold ischemia time was significantly longer in patients who developed complications (163.0 vs. 115.0,
= 0.010). The median hospital stay was 10 days (8-13). The median follow-up was 51.5 months.
NAT emerges as a successful therapeutic strategy for a highly select group of patients dealing with intricate ureteral lesions and kidney vascular abnormalities, demonstrating positive outcomes that endure in the long term.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm13061641</identifier><identifier>PMID: 38541867</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Aneurysms ; Angioplasty ; Antihypertensives ; Autografts ; Evaluation ; Hematuria ; Hypertension ; Infections ; Ischemia ; Kidneys ; Laparoscopy ; Methods ; Nephrectomy ; Ostomy ; Ovaries ; Patient outcomes ; Patients ; Small intestine ; Surgery ; Surgical outcomes ; Surgical techniques ; Urogenital system ; Veins & arteries</subject><ispartof>Journal of clinical medicine, 2024-03, Vol.13 (6), p.1641</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c435t-82b2fc127579859137f229c5f0345dcb12e4f0eec6ece408de18d6d5390e2b973</cites><orcidid>0000-0002-5841-8966 ; 0000-0001-8482-5314 ; 0000-0002-8222-0511 ; 0000-0002-1232-3232</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10971209/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10971209/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38541867$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mesquita, Sofia</creatorcontrib><creatorcontrib>Marques-Monteiro, Miguel</creatorcontrib><creatorcontrib>Madanelo, Mariana</creatorcontrib><creatorcontrib>Rocha, Maria Alexandra</creatorcontrib><creatorcontrib>Vinagre, Nuno</creatorcontrib><creatorcontrib>Fraga, Avelino</creatorcontrib><creatorcontrib>Cavadas, Vítor</creatorcontrib><creatorcontrib>Machado, Rui</creatorcontrib><creatorcontrib>Silva-Ramos, Miguel</creatorcontrib><title>Nephrectomy with Autotransplantation-A Key Treasure</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Nephrectomy with autotransplantation (NAT) has been performed as an alternative treatment for complex renovascular lesions, intricate ureteral strictures and nephron-sparing surgery in complex renal tumors.
: A retrospective observational study was conducted including patients who underwent a NAT from January 2010 to September 2023. Data collected included surgery indications, surgical technique, complications according to Clavien-Dindo classification and mean hospital stay. Descriptive and inferential statistical analysis was performed using IBM
SPSS
Statistics version 28.0.1.0.
A total of 34 consecutive patients underwent 38 NATs at our institution. Surgery indications were complex renovascular conditions in 35 cases (92.1%), of which 24 had renal artery aneurysms, and ureteral injuries in 3 cases (7.9%). Thirty-four kidneys (89.5%) were retrieved through a laparoscopic approach. No significant difference was observed between post- and pre-operative creatinine levels (0.81 vs. 0.72,
= 0.303). Early high-grade complications developed in 12 procedures (31.6%). Median cold ischemia time was significantly longer in patients who developed complications (163.0 vs. 115.0,
= 0.010). The median hospital stay was 10 days (8-13). The median follow-up was 51.5 months.
NAT emerges as a successful therapeutic strategy for a highly select group of patients dealing with intricate ureteral lesions and kidney vascular abnormalities, demonstrating positive outcomes that endure in the long term.</description><subject>Aneurysms</subject><subject>Angioplasty</subject><subject>Antihypertensives</subject><subject>Autografts</subject><subject>Evaluation</subject><subject>Hematuria</subject><subject>Hypertension</subject><subject>Infections</subject><subject>Ischemia</subject><subject>Kidneys</subject><subject>Laparoscopy</subject><subject>Methods</subject><subject>Nephrectomy</subject><subject>Ostomy</subject><subject>Ovaries</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Small intestine</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><subject>Surgical techniques</subject><subject>Urogenital system</subject><subject>Veins & arteries</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkUtLxDAUhYMoKurKvQy4EaR682rSlQziC0U3ug6d9NbJ0DZj0irz783gaxSTRULy3cM99xCyT-GE8wJOZ7alHHKaC7pGthkolQHXfH3lvkX2YpxBWloLRtUm2eJaCqpztU34Pc6nAW3v28XozfXT0XjofR_KLs6bsuvL3vkuG49ucTF6DFjGIeAu2ajLJuLe57lDni4vHs-vs7uHq5vz8V1mBZd9ptmE1ZYyJVWhZUG5qhkrrKyBC1nZCWUoakC0OVoUoCukusormWwhmxSK75CzD935MGmxstilvhozD64tw8L40pnfP52bmmf_aigUijIoksLRp0LwLwPG3rQuWmySM_RDNByogAQDJPTwDzrzQ-iSv0QBKyjlMv-hnssGjevq5ajsUtSMldZMaC2XjZ_8Q6VdYeus77B26f1XwfFHgQ0-xoD1t0kKZpmzWck50Qerc_lmv1Ll7wpzoJ0</recordid><startdate>20240313</startdate><enddate>20240313</enddate><creator>Mesquita, Sofia</creator><creator>Marques-Monteiro, Miguel</creator><creator>Madanelo, Mariana</creator><creator>Rocha, Maria Alexandra</creator><creator>Vinagre, Nuno</creator><creator>Fraga, Avelino</creator><creator>Cavadas, Vítor</creator><creator>Machado, Rui</creator><creator>Silva-Ramos, Miguel</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5841-8966</orcidid><orcidid>https://orcid.org/0000-0001-8482-5314</orcidid><orcidid>https://orcid.org/0000-0002-8222-0511</orcidid><orcidid>https://orcid.org/0000-0002-1232-3232</orcidid></search><sort><creationdate>20240313</creationdate><title>Nephrectomy with Autotransplantation-A Key Treasure</title><author>Mesquita, Sofia ; 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: A retrospective observational study was conducted including patients who underwent a NAT from January 2010 to September 2023. Data collected included surgery indications, surgical technique, complications according to Clavien-Dindo classification and mean hospital stay. Descriptive and inferential statistical analysis was performed using IBM
SPSS
Statistics version 28.0.1.0.
A total of 34 consecutive patients underwent 38 NATs at our institution. Surgery indications were complex renovascular conditions in 35 cases (92.1%), of which 24 had renal artery aneurysms, and ureteral injuries in 3 cases (7.9%). Thirty-four kidneys (89.5%) were retrieved through a laparoscopic approach. No significant difference was observed between post- and pre-operative creatinine levels (0.81 vs. 0.72,
= 0.303). Early high-grade complications developed in 12 procedures (31.6%). Median cold ischemia time was significantly longer in patients who developed complications (163.0 vs. 115.0,
= 0.010). The median hospital stay was 10 days (8-13). The median follow-up was 51.5 months.
NAT emerges as a successful therapeutic strategy for a highly select group of patients dealing with intricate ureteral lesions and kidney vascular abnormalities, demonstrating positive outcomes that endure in the long term.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38541867</pmid><doi>10.3390/jcm13061641</doi><orcidid>https://orcid.org/0000-0002-5841-8966</orcidid><orcidid>https://orcid.org/0000-0001-8482-5314</orcidid><orcidid>https://orcid.org/0000-0002-8222-0511</orcidid><orcidid>https://orcid.org/0000-0002-1232-3232</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Aneurysms Angioplasty Antihypertensives Autografts Evaluation Hematuria Hypertension Infections Ischemia Kidneys Laparoscopy Methods Nephrectomy Ostomy Ovaries Patient outcomes Patients Small intestine Surgery Surgical outcomes Surgical techniques Urogenital system Veins & arteries |
| title | Nephrectomy with Autotransplantation-A Key Treasure |
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