Neuroprotective Effects of Aucubin against Cerebral Ischemia and Ischemia Injury through the Inhibition of the TLR4/NF-κB Inflammatory Signaling Pathway in Gerbils

Aucubin, an iridoid glycoside, possesses beneficial bioactivities in many diseases, but little is known about its neuroprotective effects and mechanisms in brain ischemia and reperfusion (IR) injury. This study evaluated whether aucubin exhibited neuroprotective effects against IR injury in the hipp...

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Veröffentlicht in:	International journal of molecular sciences 2024-03, Vol.25 (6), p.3461
Hauptverfasser:	Park, Joon Ha, Lee, Tae-Kyeong, Kim, Dae Won, Ahn, Ji Hyeon, Shin, Myoung Cheol, Cho, Jun Hwi, Won, Moo-Ho, Kang, Il Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Brain Ischemia - drug therapy Brain Ischemia - metabolism Cerebral Infarction Cerebral ischemia Cytokines Enzyme-linked immunosorbent assay Gerbillinae - metabolism Gliosis Iridoid Glucosides Ischemia Neurons Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use NF-kappa B - metabolism NF-KappaB Inhibitor alpha - metabolism Protein binding Proteins Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Signal Transduction Toll-Like Receptor 4 - metabolism Tumor Necrosis Factor-alpha - metabolism
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