Association between Albumin Alterations and Renal Function in Patients with Type 2 Diabetes Mellitus
Diabetic kidney disease (DKD) is a major cause of morbidity and mortality in individuals with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate whether albumin structural alterations correlate with DKD severity and evaluate whether native and reduced albumin concentrations co...
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| Veröffentlicht in: | International journal of molecular sciences 2024-03, Vol.25 (6), p.3168 |
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| creator | Nugnes, Marta Baldassarre, Maurizio Ribichini, Danilo Tedesco, Daniele Capelli, Irene Vetrano, Daniele Marchignoli, Francesca Brodosi, Lucia Pompili, Enrico Petroni, Maria Letizia La Manna, Gaetano Marchesini, Giulio Naldi, Marina Bartolini, Manuela |
| description | Diabetic kidney disease (DKD) is a major cause of morbidity and mortality in individuals with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate whether albumin structural alterations correlate with DKD severity and evaluate whether native and reduced albumin concentrations could complement the diagnosis of DKD. To this end, one hundred and seventeen T2DM patients without (
= 42) and with (
= 75) DKD (DKD I-III upon KDIGO classification) were evaluated; the total albumin concentration (tHA) was quantified by a bromocresol green assay, while structural alterations were profiled via liquid chromatography-high-resolution mass spectrometry (LC-HRMS). The concentrations of native albumin (eHA, effective albumin) and reduced albumin (rHA) were subsequently assessed. The HRMS analyses revealed a reduced relative amount of native albumin in DKD patients along with an increased abundance of altered forms, especially those bearing oxidative modifications. Accordingly, both eHA and rHA values varied during the stages of progressive renal failure, and these alterations were dose-dependently correlated with renal dysfunction. A ROC curve analysis revealed a significantly greater sensitivity and specificity of eHA and rHA than of tHA for diagnosing DKD. Importantly, according to the multivariate logistic regression analysis, the eHA was identified as an independent predictor of DKD. |
| doi_str_mv | 10.3390/ijms25063168 |
| format | Article |
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= 42) and with (
= 75) DKD (DKD I-III upon KDIGO classification) were evaluated; the total albumin concentration (tHA) was quantified by a bromocresol green assay, while structural alterations were profiled via liquid chromatography-high-resolution mass spectrometry (LC-HRMS). The concentrations of native albumin (eHA, effective albumin) and reduced albumin (rHA) were subsequently assessed. The HRMS analyses revealed a reduced relative amount of native albumin in DKD patients along with an increased abundance of altered forms, especially those bearing oxidative modifications. Accordingly, both eHA and rHA values varied during the stages of progressive renal failure, and these alterations were dose-dependently correlated with renal dysfunction. A ROC curve analysis revealed a significantly greater sensitivity and specificity of eHA and rHA than of tHA for diagnosing DKD. Importantly, according to the multivariate logistic regression analysis, the eHA was identified as an independent predictor of DKD.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms25063168</identifier><identifier>PMID: 38542146</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Albumin ; BCG ; BCG vaccines ; Biomarkers ; Care and treatment ; Chronic illnesses ; Development and progression ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Diabetic Nephropathies - complications ; Diagnosis ; Glomerular Filtration Rate ; Health aspects ; High density lipoprotein ; Humans ; Kidney ; Kidney diseases ; Liquid chromatography ; Liver cirrhosis ; Mass spectrometry ; Medical prognosis ; Morbidity ; Mortality ; Oxidation ; Patients ; Proteins ; Sensitivity and Specificity ; Type 2 diabetes</subject><ispartof>International journal of molecular sciences, 2024-03, Vol.25 (6), p.3168</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c437t-87fcba17d689fbb8e9a02dbe527c7ee641e702988bb60db14578c7d1134525773</cites><orcidid>0000-0002-6263-6202 ; 0000-0003-2585-7791 ; 0000-0002-2890-3856 ; 0000-0003-4468-2974 ; 0000-0002-4862-1274 ; 0000-0001-5473-8551 ; 0000-0003-2407-9860 ; 0000-0001-7865-394X ; 0000-0002-7040-6466 ; 0000-0002-7735-7847 ; 0000-0003-2467-7027</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10970212/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10970212/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38542146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nugnes, Marta</creatorcontrib><creatorcontrib>Baldassarre, Maurizio</creatorcontrib><creatorcontrib>Ribichini, Danilo</creatorcontrib><creatorcontrib>Tedesco, Daniele</creatorcontrib><creatorcontrib>Capelli, Irene</creatorcontrib><creatorcontrib>Vetrano, Daniele</creatorcontrib><creatorcontrib>Marchignoli, Francesca</creatorcontrib><creatorcontrib>Brodosi, Lucia</creatorcontrib><creatorcontrib>Pompili, Enrico</creatorcontrib><creatorcontrib>Petroni, Maria Letizia</creatorcontrib><creatorcontrib>La Manna, Gaetano</creatorcontrib><creatorcontrib>Marchesini, Giulio</creatorcontrib><creatorcontrib>Naldi, Marina</creatorcontrib><creatorcontrib>Bartolini, Manuela</creatorcontrib><title>Association between Albumin Alterations and Renal Function in Patients with Type 2 Diabetes Mellitus</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Diabetic kidney disease (DKD) is a major cause of morbidity and mortality in individuals with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate whether albumin structural alterations correlate with DKD severity and evaluate whether native and reduced albumin concentrations could complement the diagnosis of DKD. To this end, one hundred and seventeen T2DM patients without (
= 42) and with (
= 75) DKD (DKD I-III upon KDIGO classification) were evaluated; the total albumin concentration (tHA) was quantified by a bromocresol green assay, while structural alterations were profiled via liquid chromatography-high-resolution mass spectrometry (LC-HRMS). The concentrations of native albumin (eHA, effective albumin) and reduced albumin (rHA) were subsequently assessed. The HRMS analyses revealed a reduced relative amount of native albumin in DKD patients along with an increased abundance of altered forms, especially those bearing oxidative modifications. Accordingly, both eHA and rHA values varied during the stages of progressive renal failure, and these alterations were dose-dependently correlated with renal dysfunction. A ROC curve analysis revealed a significantly greater sensitivity and specificity of eHA and rHA than of tHA for diagnosing DKD. Importantly, according to the multivariate logistic regression analysis, the eHA was identified as an independent predictor of DKD.</description><subject>Albumin</subject><subject>BCG</subject><subject>BCG vaccines</subject><subject>Biomarkers</subject><subject>Care and treatment</subject><subject>Chronic illnesses</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetic Nephropathies - complications</subject><subject>Diagnosis</subject><subject>Glomerular Filtration Rate</subject><subject>Health aspects</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Kidney</subject><subject>Kidney diseases</subject><subject>Liquid chromatography</subject><subject>Liver cirrhosis</subject><subject>Mass spectrometry</subject><subject>Medical prognosis</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Oxidation</subject><subject>Patients</subject><subject>Proteins</subject><subject>Sensitivity and Specificity</subject><subject>Type 2 diabetes</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks9PFTEQxxujEURvnk0TLxx8MP2x2-7JvCAoCQZj8Ny03Vnoy2773O5K-O_pA4SHMT1M0-9nvp2ZDCHvGRwI0cBhWA2ZV1ALVusXZJdJzhcAtXq5dd8hb3JeAXDBq-Y12RG6kpzJepe0y5yTD3YKKVKH0zVipMvezUPYxAnHOylTG1v6E6Pt6ckc_R1eiB9FxThleh2mK3pxs0bK6ZdgixNm-h37PkxzfktedbbP-O4h7pFfJ8cXR98WZ-dfT4-WZwsvhZoWWnXeWabaWjedcxobC7x1WHHlFWItGSrgjdbO1dA6JiulvWoZE7LilVJij3y-913PbsDWl8pG25v1GAY73phkg3muxHBlLtMfw6ApzowXh_0HhzH9njFPZgjZlzZsxDRnI4BJAK15U9CP_6CrNI9lQBsKhIBSkniiLm2PJsQulY_9xtQsVfGRGlRdqIP_UOW0OASfInahvD9L-HSf4MeU84jdY5MMzGYtzPZaFPzD9mAe4b97IG4B4AiyRw</recordid><startdate>20240309</startdate><enddate>20240309</enddate><creator>Nugnes, Marta</creator><creator>Baldassarre, Maurizio</creator><creator>Ribichini, Danilo</creator><creator>Tedesco, Daniele</creator><creator>Capelli, Irene</creator><creator>Vetrano, Daniele</creator><creator>Marchignoli, Francesca</creator><creator>Brodosi, Lucia</creator><creator>Pompili, Enrico</creator><creator>Petroni, Maria Letizia</creator><creator>La Manna, Gaetano</creator><creator>Marchesini, Giulio</creator><creator>Naldi, Marina</creator><creator>Bartolini, Manuela</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6263-6202</orcidid><orcidid>https://orcid.org/0000-0003-2585-7791</orcidid><orcidid>https://orcid.org/0000-0002-2890-3856</orcidid><orcidid>https://orcid.org/0000-0003-4468-2974</orcidid><orcidid>https://orcid.org/0000-0002-4862-1274</orcidid><orcidid>https://orcid.org/0000-0001-5473-8551</orcidid><orcidid>https://orcid.org/0000-0003-2407-9860</orcidid><orcidid>https://orcid.org/0000-0001-7865-394X</orcidid><orcidid>https://orcid.org/0000-0002-7040-6466</orcidid><orcidid>https://orcid.org/0000-0002-7735-7847</orcidid><orcidid>https://orcid.org/0000-0003-2467-7027</orcidid></search><sort><creationdate>20240309</creationdate><title>Association between Albumin Alterations and Renal Function in Patients with Type 2 Diabetes Mellitus</title><author>Nugnes, Marta ; Baldassarre, Maurizio ; Ribichini, Danilo ; Tedesco, Daniele ; Capelli, Irene ; Vetrano, Daniele ; Marchignoli, Francesca ; Brodosi, Lucia ; Pompili, Enrico ; Petroni, Maria Letizia ; La Manna, Gaetano ; Marchesini, Giulio ; Naldi, Marina ; Bartolini, Manuela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-87fcba17d689fbb8e9a02dbe527c7ee641e702988bb60db14578c7d1134525773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Albumin</topic><topic>BCG</topic><topic>BCG vaccines</topic><topic>Biomarkers</topic><topic>Care and treatment</topic><topic>Chronic illnesses</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - 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The aim of this study was to investigate whether albumin structural alterations correlate with DKD severity and evaluate whether native and reduced albumin concentrations could complement the diagnosis of DKD. To this end, one hundred and seventeen T2DM patients without (
= 42) and with (
= 75) DKD (DKD I-III upon KDIGO classification) were evaluated; the total albumin concentration (tHA) was quantified by a bromocresol green assay, while structural alterations were profiled via liquid chromatography-high-resolution mass spectrometry (LC-HRMS). The concentrations of native albumin (eHA, effective albumin) and reduced albumin (rHA) were subsequently assessed. The HRMS analyses revealed a reduced relative amount of native albumin in DKD patients along with an increased abundance of altered forms, especially those bearing oxidative modifications. Accordingly, both eHA and rHA values varied during the stages of progressive renal failure, and these alterations were dose-dependently correlated with renal dysfunction. A ROC curve analysis revealed a significantly greater sensitivity and specificity of eHA and rHA than of tHA for diagnosing DKD. Importantly, according to the multivariate logistic regression analysis, the eHA was identified as an independent predictor of DKD.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38542146</pmid><doi>10.3390/ijms25063168</doi><orcidid>https://orcid.org/0000-0002-6263-6202</orcidid><orcidid>https://orcid.org/0000-0003-2585-7791</orcidid><orcidid>https://orcid.org/0000-0002-2890-3856</orcidid><orcidid>https://orcid.org/0000-0003-4468-2974</orcidid><orcidid>https://orcid.org/0000-0002-4862-1274</orcidid><orcidid>https://orcid.org/0000-0001-5473-8551</orcidid><orcidid>https://orcid.org/0000-0003-2407-9860</orcidid><orcidid>https://orcid.org/0000-0001-7865-394X</orcidid><orcidid>https://orcid.org/0000-0002-7040-6466</orcidid><orcidid>https://orcid.org/0000-0002-7735-7847</orcidid><orcidid>https://orcid.org/0000-0003-2467-7027</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2024-03, Vol.25 (6), p.3168 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Albumin BCG BCG vaccines Biomarkers Care and treatment Chronic illnesses Development and progression Diabetes Diabetes Mellitus, Type 2 - complications Diabetic Nephropathies - complications Diagnosis Glomerular Filtration Rate Health aspects High density lipoprotein Humans Kidney Kidney diseases Liquid chromatography Liver cirrhosis Mass spectrometry Medical prognosis Morbidity Mortality Oxidation Patients Proteins Sensitivity and Specificity Type 2 diabetes |
| title | Association between Albumin Alterations and Renal Function in Patients with Type 2 Diabetes Mellitus |
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