Renin-Angiotensin Inhibitor, Captopril, Attenuates Growth of Patient-Derived Colorectal Liver Metastasis Organoids

The recurrence of colorectal liver metastasis (CRLM) following liver resection is common; approximately 40% of patients will experience tumor recurrence post-surgery. Renin-angiotensin inhibitors (RASis) have been shown to attenuate the growth and progression of CRLM in pre-clinical models following...

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Veröffentlicht in:	International journal of molecular sciences 2024-03, Vol.25 (6), p.3282
Hauptverfasser:	Riddiough, Georgina E, Fifis, Theodora, Muralidharan, Vijayaragavan, Christophi, Christopher, Tran, Bang M, Perini, Marcos V, Vincan, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensins Brief Report Cancer therapies Captopril Captopril - pharmacology Chemotherapy Colorectal cancer Colorectal Neoplasms - pathology Diseases Genes Genetic engineering Growth Hepatectomy Histopathology Humans Liver Liver cancer Liver Neoplasms - secondary Metastasis Mutation Neoplasm Recurrence, Local - pathology Organoids Patients Relapse Renin Renin Inhibitors Stem cells Surveillance Tumors
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