Hsp70 and Calcitonin Receptor Protein in Extracellular Vesicles from Glioblastoma Multiforme: Biomarkers with Putative Roles in Carcinogenesis and Potential for Differentiating Tumor Types
Glioblastoma multiforme (GBM) is a malignancy of bad prognosis, and advances in early detection and treatment are needed. GBM is heterogenous, with varieties differing in malignancy within a tumor of a patient and between patients. Means are needed to distinguish these GMB forms, so that specific st...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2024-03, Vol.25 (6), p.3415 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 6 |
| container_start_page | 3415 |
| container_title | International journal of molecular sciences |
| container_volume | 25 |
| creator | Alberti, Giusi Sánchez-López, Christian M Marcilla, Antonio Barone, Rosario Caruso Bavisotto, Celeste Graziano, Francesca Conway de Macario, Everly Macario, Alberto J L Bucchieri, Fabio Cappello, Francesco Campanella, Claudia Rappa, Francesca |
| description | Glioblastoma multiforme (GBM) is a malignancy of bad prognosis, and advances in early detection and treatment are needed. GBM is heterogenous, with varieties differing in malignancy within a tumor of a patient and between patients. Means are needed to distinguish these GMB forms, so that specific strategies can be deployed for patient management. We study the participation of the chaperone system (CS) in carcinogenesis. The CS is dynamic, with its members moving around the body in extracellular vesicles (EVs) and interacting with components of other physiological systems in health and disease, including GBM. Here, we describe the finding of high amounts of Hsp70 (HSPA1A) and the calcitonin receptor protein (CTR) in EVs in patients with GBM. We present a standardized protocol for collecting, purifying, and characterizing EVs carrying Hsp70 and CTR in plasma-derived EVs from patients with GBM. EVs from GBM patients were obtained just before tumor ablative surgery (T0) and 7 days afterwards (T1); Hsp70 was highly elevated at T0 and less so at T1, and CTR was greatly increased at T0 and reduced to below normal values at T1. Our results encourage further research to assess Hsp70 and CTR as biomarkers for differentiating tumor forms and to determine their roles in GBM carcinogenesis. |
| doi_str_mv | 10.3390/ijms25063415 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10969952</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A788248354</galeid><sourcerecordid>A788248354</sourcerecordid><originalsourceid>FETCH-LOGICAL-c480t-1ba866f90fe56a9aee208d6caf7e70003bea84cbc4842f81abc025acc67643e63</originalsourceid><addsrcrecordid>eNptkl1vVCEQhk-Mxn7ondeGxBsv3DoHOF_eNHWtrUmNm2b1lnDYYcvKgRU4rf1v_jjZttatMZBAXp55mYEpihclHDDWwVuzGiKtoGa8rB4VuyWndAJQN4-39jvFXowrAMpo1T0tdlhbccrabrf4dRrXDRDpFmQqrTLJO-PIOSpcJx_ILPiEWcjz-GcKUqG1o5WBfMNolMVIdPADObHG91bG5AdJPo82Ge3DgO_Ie5OV8B1DJFcmXZDZmGQyl0jO_SY4205lUMb5JbrsGG8SmeU7XTLSkuxCPhitMdwIybglmY9DVufXa4zPiida2ojP79b94uvH4_n0dHL25eTT9OhsongLaVL2sq1r3YHGqpadRKTQLmoldYMNALAeZctVn2lOdVvKXgGtpFJ1U3OGNdsvDm9912M_4ELlZIK0Yh1MLu5aeGnEwxNnLsTSX4oSurrrKpodXt85BP9jxJjEYOLmMaVDP0bBoOQATVWyjL76B135MbhcX6aAAeOMN3-ppbQojNN-8zsbU3HUtC3lLat4pg7-Q-WxwMEo71CbrD8IeHMboIKPMaC-L7IEsWk3sd1uGX-5_TD38J_-Yr8B8YzUuQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3003034347</pqid></control><display><type>article</type><title>Hsp70 and Calcitonin Receptor Protein in Extracellular Vesicles from Glioblastoma Multiforme: Biomarkers with Putative Roles in Carcinogenesis and Potential for Differentiating Tumor Types</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Alberti, Giusi ; Sánchez-López, Christian M ; Marcilla, Antonio ; Barone, Rosario ; Caruso Bavisotto, Celeste ; Graziano, Francesca ; Conway de Macario, Everly ; Macario, Alberto J L ; Bucchieri, Fabio ; Cappello, Francesco ; Campanella, Claudia ; Rappa, Francesca</creator><creatorcontrib>Alberti, Giusi ; Sánchez-López, Christian M ; Marcilla, Antonio ; Barone, Rosario ; Caruso Bavisotto, Celeste ; Graziano, Francesca ; Conway de Macario, Everly ; Macario, Alberto J L ; Bucchieri, Fabio ; Cappello, Francesco ; Campanella, Claudia ; Rappa, Francesca</creatorcontrib><description>Glioblastoma multiforme (GBM) is a malignancy of bad prognosis, and advances in early detection and treatment are needed. GBM is heterogenous, with varieties differing in malignancy within a tumor of a patient and between patients. Means are needed to distinguish these GMB forms, so that specific strategies can be deployed for patient management. We study the participation of the chaperone system (CS) in carcinogenesis. The CS is dynamic, with its members moving around the body in extracellular vesicles (EVs) and interacting with components of other physiological systems in health and disease, including GBM. Here, we describe the finding of high amounts of Hsp70 (HSPA1A) and the calcitonin receptor protein (CTR) in EVs in patients with GBM. We present a standardized protocol for collecting, purifying, and characterizing EVs carrying Hsp70 and CTR in plasma-derived EVs from patients with GBM. EVs from GBM patients were obtained just before tumor ablative surgery (T0) and 7 days afterwards (T1); Hsp70 was highly elevated at T0 and less so at T1, and CTR was greatly increased at T0 and reduced to below normal values at T1. Our results encourage further research to assess Hsp70 and CTR as biomarkers for differentiating tumor forms and to determine their roles in GBM carcinogenesis.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms25063415</identifier><identifier>PMID: 38542389</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Biological markers ; Biomarkers ; Biomarkers, Tumor - metabolism ; Brain Neoplasms - metabolism ; Calcitonin ; Cancer ; Carcinogenesis ; Carcinogenesis - metabolism ; Cell Line, Tumor ; Development and progression ; Ethylenediaminetetraacetic acid ; Extracellular vesicles ; Extracellular Vesicles - metabolism ; Glioblastoma - metabolism ; Glioblastoma multiforme ; Heat shock proteins ; Humans ; Medical research ; Medicine, Experimental ; Patients ; Physiological aspects ; Plasma ; Prognosis ; Receptors, Calcitonin - metabolism ; Surgery</subject><ispartof>International journal of molecular sciences, 2024-03, Vol.25 (6), p.3415</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-1ba866f90fe56a9aee208d6caf7e70003bea84cbc4842f81abc025acc67643e63</citedby><cites>FETCH-LOGICAL-c480t-1ba866f90fe56a9aee208d6caf7e70003bea84cbc4842f81abc025acc67643e63</cites><orcidid>0000-0002-6181-2876 ; 0000-0003-0004-0531 ; 0000-0001-8260-8471 ; 0000-0001-6062-5940 ; 0000-0001-6610-5268 ; 0000-0001-6491-3640 ; 0000-0001-9288-1148</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10969952/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10969952/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38542389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alberti, Giusi</creatorcontrib><creatorcontrib>Sánchez-López, Christian M</creatorcontrib><creatorcontrib>Marcilla, Antonio</creatorcontrib><creatorcontrib>Barone, Rosario</creatorcontrib><creatorcontrib>Caruso Bavisotto, Celeste</creatorcontrib><creatorcontrib>Graziano, Francesca</creatorcontrib><creatorcontrib>Conway de Macario, Everly</creatorcontrib><creatorcontrib>Macario, Alberto J L</creatorcontrib><creatorcontrib>Bucchieri, Fabio</creatorcontrib><creatorcontrib>Cappello, Francesco</creatorcontrib><creatorcontrib>Campanella, Claudia</creatorcontrib><creatorcontrib>Rappa, Francesca</creatorcontrib><title>Hsp70 and Calcitonin Receptor Protein in Extracellular Vesicles from Glioblastoma Multiforme: Biomarkers with Putative Roles in Carcinogenesis and Potential for Differentiating Tumor Types</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Glioblastoma multiforme (GBM) is a malignancy of bad prognosis, and advances in early detection and treatment are needed. GBM is heterogenous, with varieties differing in malignancy within a tumor of a patient and between patients. Means are needed to distinguish these GMB forms, so that specific strategies can be deployed for patient management. We study the participation of the chaperone system (CS) in carcinogenesis. The CS is dynamic, with its members moving around the body in extracellular vesicles (EVs) and interacting with components of other physiological systems in health and disease, including GBM. Here, we describe the finding of high amounts of Hsp70 (HSPA1A) and the calcitonin receptor protein (CTR) in EVs in patients with GBM. We present a standardized protocol for collecting, purifying, and characterizing EVs carrying Hsp70 and CTR in plasma-derived EVs from patients with GBM. EVs from GBM patients were obtained just before tumor ablative surgery (T0) and 7 days afterwards (T1); Hsp70 was highly elevated at T0 and less so at T1, and CTR was greatly increased at T0 and reduced to below normal values at T1. Our results encourage further research to assess Hsp70 and CTR as biomarkers for differentiating tumor forms and to determine their roles in GBM carcinogenesis.</description><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Brain Neoplasms - metabolism</subject><subject>Calcitonin</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Carcinogenesis - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Development and progression</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Extracellular vesicles</subject><subject>Extracellular Vesicles - metabolism</subject><subject>Glioblastoma - metabolism</subject><subject>Glioblastoma multiforme</subject><subject>Heat shock proteins</subject><subject>Humans</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Plasma</subject><subject>Prognosis</subject><subject>Receptors, Calcitonin - metabolism</subject><subject>Surgery</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkl1vVCEQhk-Mxn7ondeGxBsv3DoHOF_eNHWtrUmNm2b1lnDYYcvKgRU4rf1v_jjZttatMZBAXp55mYEpihclHDDWwVuzGiKtoGa8rB4VuyWndAJQN4-39jvFXowrAMpo1T0tdlhbccrabrf4dRrXDRDpFmQqrTLJO-PIOSpcJx_ILPiEWcjz-GcKUqG1o5WBfMNolMVIdPADObHG91bG5AdJPo82Ge3DgO_Ie5OV8B1DJFcmXZDZmGQyl0jO_SY4205lUMb5JbrsGG8SmeU7XTLSkuxCPhitMdwIybglmY9DVufXa4zPiida2ojP79b94uvH4_n0dHL25eTT9OhsongLaVL2sq1r3YHGqpadRKTQLmoldYMNALAeZctVn2lOdVvKXgGtpFJ1U3OGNdsvDm9912M_4ELlZIK0Yh1MLu5aeGnEwxNnLsTSX4oSurrrKpodXt85BP9jxJjEYOLmMaVDP0bBoOQATVWyjL76B135MbhcX6aAAeOMN3-ppbQojNN-8zsbU3HUtC3lLat4pg7-Q-WxwMEo71CbrD8IeHMboIKPMaC-L7IEsWk3sd1uGX-5_TD38J_-Yr8B8YzUuQ</recordid><startdate>20240318</startdate><enddate>20240318</enddate><creator>Alberti, Giusi</creator><creator>Sánchez-López, Christian M</creator><creator>Marcilla, Antonio</creator><creator>Barone, Rosario</creator><creator>Caruso Bavisotto, Celeste</creator><creator>Graziano, Francesca</creator><creator>Conway de Macario, Everly</creator><creator>Macario, Alberto J L</creator><creator>Bucchieri, Fabio</creator><creator>Cappello, Francesco</creator><creator>Campanella, Claudia</creator><creator>Rappa, Francesca</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6181-2876</orcidid><orcidid>https://orcid.org/0000-0003-0004-0531</orcidid><orcidid>https://orcid.org/0000-0001-8260-8471</orcidid><orcidid>https://orcid.org/0000-0001-6062-5940</orcidid><orcidid>https://orcid.org/0000-0001-6610-5268</orcidid><orcidid>https://orcid.org/0000-0001-6491-3640</orcidid><orcidid>https://orcid.org/0000-0001-9288-1148</orcidid></search><sort><creationdate>20240318</creationdate><title>Hsp70 and Calcitonin Receptor Protein in Extracellular Vesicles from Glioblastoma Multiforme: Biomarkers with Putative Roles in Carcinogenesis and Potential for Differentiating Tumor Types</title><author>Alberti, Giusi ; Sánchez-López, Christian M ; Marcilla, Antonio ; Barone, Rosario ; Caruso Bavisotto, Celeste ; Graziano, Francesca ; Conway de Macario, Everly ; Macario, Alberto J L ; Bucchieri, Fabio ; Cappello, Francesco ; Campanella, Claudia ; Rappa, Francesca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-1ba866f90fe56a9aee208d6caf7e70003bea84cbc4842f81abc025acc67643e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Brain Neoplasms - metabolism</topic><topic>Calcitonin</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Carcinogenesis - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Development and progression</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Extracellular vesicles</topic><topic>Extracellular Vesicles - metabolism</topic><topic>Glioblastoma - metabolism</topic><topic>Glioblastoma multiforme</topic><topic>Heat shock proteins</topic><topic>Humans</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Patients</topic><topic>Physiological aspects</topic><topic>Plasma</topic><topic>Prognosis</topic><topic>Receptors, Calcitonin - metabolism</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alberti, Giusi</creatorcontrib><creatorcontrib>Sánchez-López, Christian M</creatorcontrib><creatorcontrib>Marcilla, Antonio</creatorcontrib><creatorcontrib>Barone, Rosario</creatorcontrib><creatorcontrib>Caruso Bavisotto, Celeste</creatorcontrib><creatorcontrib>Graziano, Francesca</creatorcontrib><creatorcontrib>Conway de Macario, Everly</creatorcontrib><creatorcontrib>Macario, Alberto J L</creatorcontrib><creatorcontrib>Bucchieri, Fabio</creatorcontrib><creatorcontrib>Cappello, Francesco</creatorcontrib><creatorcontrib>Campanella, Claudia</creatorcontrib><creatorcontrib>Rappa, Francesca</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alberti, Giusi</au><au>Sánchez-López, Christian M</au><au>Marcilla, Antonio</au><au>Barone, Rosario</au><au>Caruso Bavisotto, Celeste</au><au>Graziano, Francesca</au><au>Conway de Macario, Everly</au><au>Macario, Alberto J L</au><au>Bucchieri, Fabio</au><au>Cappello, Francesco</au><au>Campanella, Claudia</au><au>Rappa, Francesca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hsp70 and Calcitonin Receptor Protein in Extracellular Vesicles from Glioblastoma Multiforme: Biomarkers with Putative Roles in Carcinogenesis and Potential for Differentiating Tumor Types</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2024-03-18</date><risdate>2024</risdate><volume>25</volume><issue>6</issue><spage>3415</spage><pages>3415-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Glioblastoma multiforme (GBM) is a malignancy of bad prognosis, and advances in early detection and treatment are needed. GBM is heterogenous, with varieties differing in malignancy within a tumor of a patient and between patients. Means are needed to distinguish these GMB forms, so that specific strategies can be deployed for patient management. We study the participation of the chaperone system (CS) in carcinogenesis. The CS is dynamic, with its members moving around the body in extracellular vesicles (EVs) and interacting with components of other physiological systems in health and disease, including GBM. Here, we describe the finding of high amounts of Hsp70 (HSPA1A) and the calcitonin receptor protein (CTR) in EVs in patients with GBM. We present a standardized protocol for collecting, purifying, and characterizing EVs carrying Hsp70 and CTR in plasma-derived EVs from patients with GBM. EVs from GBM patients were obtained just before tumor ablative surgery (T0) and 7 days afterwards (T1); Hsp70 was highly elevated at T0 and less so at T1, and CTR was greatly increased at T0 and reduced to below normal values at T1. Our results encourage further research to assess Hsp70 and CTR as biomarkers for differentiating tumor forms and to determine their roles in GBM carcinogenesis.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38542389</pmid><doi>10.3390/ijms25063415</doi><orcidid>https://orcid.org/0000-0002-6181-2876</orcidid><orcidid>https://orcid.org/0000-0003-0004-0531</orcidid><orcidid>https://orcid.org/0000-0001-8260-8471</orcidid><orcidid>https://orcid.org/0000-0001-6062-5940</orcidid><orcidid>https://orcid.org/0000-0001-6610-5268</orcidid><orcidid>https://orcid.org/0000-0001-6491-3640</orcidid><orcidid>https://orcid.org/0000-0001-9288-1148</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2024-03, Vol.25 (6), p.3415 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10969952 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Biological markers Biomarkers Biomarkers, Tumor - metabolism Brain Neoplasms - metabolism Calcitonin Cancer Carcinogenesis Carcinogenesis - metabolism Cell Line, Tumor Development and progression Ethylenediaminetetraacetic acid Extracellular vesicles Extracellular Vesicles - metabolism Glioblastoma - metabolism Glioblastoma multiforme Heat shock proteins Humans Medical research Medicine, Experimental Patients Physiological aspects Plasma Prognosis Receptors, Calcitonin - metabolism Surgery |
| title | Hsp70 and Calcitonin Receptor Protein in Extracellular Vesicles from Glioblastoma Multiforme: Biomarkers with Putative Roles in Carcinogenesis and Potential for Differentiating Tumor Types |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T00%3A54%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hsp70%20and%20Calcitonin%20Receptor%20Protein%20in%20Extracellular%20Vesicles%20from%20Glioblastoma%20Multiforme:%20Biomarkers%20with%20Putative%20Roles%20in%20Carcinogenesis%20and%20Potential%20for%20Differentiating%20Tumor%20Types&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Alberti,%20Giusi&rft.date=2024-03-18&rft.volume=25&rft.issue=6&rft.spage=3415&rft.pages=3415-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms25063415&rft_dat=%3Cgale_pubme%3EA788248354%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3003034347&rft_id=info:pmid/38542389&rft_galeid=A788248354&rfr_iscdi=true |