Genetic Variations in Susceptibility to Traumatic Muscle Injuries and Muscle Pain among Brazilian High-Performance Athletes
Traumatic muscle injuries (TMIs) and muscle pain (MP) negatively impact athletes' performance and quality of life. Both conditions have a complex pathophysiology involving the interplay between genetic and environmental factors. Yet, the existing data are scarce and controversial. To provide mo...
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| Veröffentlicht in: | International journal of molecular sciences 2024-03, Vol.25 (6), p.3300 |
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| creator | Marques, Inês Soares Tavares, Valéria Vieira Neto, Beatriz Lopes, Lucas Rafael Goes, Rodrigo Araújo Guimarães, João António Matheus Perini, Jamila Alessandra Medeiros, Rui |
| description | Traumatic muscle injuries (TMIs) and muscle pain (MP) negatively impact athletes' performance and quality of life. Both conditions have a complex pathophysiology involving the interplay between genetic and environmental factors. Yet, the existing data are scarce and controversial. To provide more insights, this study aimed to investigate the association of single-nucleotide polymorphisms (SNPs) previously linked to athletic status with TMI and MP after exercise among Brazilian high-performance athletes from different sports modalities (N = 345). The impact of important environmental determinants was also assessed. From the six evaluated SNPs (
rs1815739,
rs324420,
rs8192678,
rs1042713,
rs1799983, and
rs731236), none was significantly associated with TMI. Regarding MP after exercise,
rs1815739 (CC/CT vs. TT; adjusted odds ratio (aOR) = 1.90; 95% confidence interval (95%Cl), 1.01-3.57) and
rs324420 (AA vs. AC/CC; aOR = 2.30; 95%Cl, 1.08-4.91) were independent predictors according to multivariate binomial analyses adjusted for age (≥23 vs. |
| doi_str_mv | 10.3390/ijms25063300 |
| format | Article |
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rs1815739,
rs324420,
rs8192678,
rs1042713,
rs1799983, and
rs731236), none was significantly associated with TMI. Regarding MP after exercise,
rs1815739 (CC/CT vs. TT; adjusted odds ratio (aOR) = 1.90; 95% confidence interval (95%Cl), 1.01-3.57) and
rs324420 (AA vs. AC/CC; aOR = 2.30; 95%Cl, 1.08-4.91) were independent predictors according to multivariate binomial analyses adjusted for age (≥23 vs. <23 years), sex (male vs. female), and tobacco consumption (yes vs. no). External validation is warranted to assess the predictive value of
rs1815739 and
rs324420. This could have implications for prophylactic interventions to improve athletes' quality of life.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms25063300</identifier><identifier>PMID: 38542272</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Actinin - genetics ; Adrenergic receptors ; Athletes ; Brazil - epidemiology ; Disease susceptibility ; Exercise ; Female ; Fractures ; Genetic aspects ; Genotype ; Genotype & phenotype ; Humans ; Injuries ; Male ; Muscle pain ; Muscles ; Musculoskeletal system ; Myalgia ; Physical fitness ; Political activity ; Political aspects ; Polymorphism, Single Nucleotide ; Proteins ; Quality of Life ; Regression analysis ; Single nucleotide polymorphisms ; Sports injuries ; Tobacco</subject><ispartof>International journal of molecular sciences, 2024-03, Vol.25 (6), p.3300</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c437t-76d391f5a7c85bdc05ce0d81a220a4c78d8097a1b24990893959da2c92b869cc3</cites><orcidid>0000-0003-3010-8373 ; 0000-0003-3680-7757 ; 0000-0002-2543-904X ; 0000-0002-5647-2248 ; 0000-0002-7683-0698 ; 0000-0002-5955-9904</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10969868/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10969868/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38542272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marques, Inês Soares</creatorcontrib><creatorcontrib>Tavares, Valéria</creatorcontrib><creatorcontrib>Vieira Neto, Beatriz</creatorcontrib><creatorcontrib>Lopes, Lucas Rafael</creatorcontrib><creatorcontrib>Goes, Rodrigo Araújo</creatorcontrib><creatorcontrib>Guimarães, João António Matheus</creatorcontrib><creatorcontrib>Perini, Jamila Alessandra</creatorcontrib><creatorcontrib>Medeiros, Rui</creatorcontrib><title>Genetic Variations in Susceptibility to Traumatic Muscle Injuries and Muscle Pain among Brazilian High-Performance Athletes</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Traumatic muscle injuries (TMIs) and muscle pain (MP) negatively impact athletes' performance and quality of life. Both conditions have a complex pathophysiology involving the interplay between genetic and environmental factors. Yet, the existing data are scarce and controversial. To provide more insights, this study aimed to investigate the association of single-nucleotide polymorphisms (SNPs) previously linked to athletic status with TMI and MP after exercise among Brazilian high-performance athletes from different sports modalities (N = 345). The impact of important environmental determinants was also assessed. From the six evaluated SNPs (
rs1815739,
rs324420,
rs8192678,
rs1042713,
rs1799983, and
rs731236), none was significantly associated with TMI. Regarding MP after exercise,
rs1815739 (CC/CT vs. TT; adjusted odds ratio (aOR) = 1.90; 95% confidence interval (95%Cl), 1.01-3.57) and
rs324420 (AA vs. AC/CC; aOR = 2.30; 95%Cl, 1.08-4.91) were independent predictors according to multivariate binomial analyses adjusted for age (≥23 vs. <23 years), sex (male vs. female), and tobacco consumption (yes vs. no). External validation is warranted to assess the predictive value of
rs1815739 and
rs324420. This could have implications for prophylactic interventions to improve athletes' quality of life.</description><subject>Actinin - genetics</subject><subject>Adrenergic receptors</subject><subject>Athletes</subject><subject>Brazil - epidemiology</subject><subject>Disease susceptibility</subject><subject>Exercise</subject><subject>Female</subject><subject>Fractures</subject><subject>Genetic aspects</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Injuries</subject><subject>Male</subject><subject>Muscle pain</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Myalgia</subject><subject>Physical fitness</subject><subject>Political activity</subject><subject>Political aspects</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proteins</subject><subject>Quality of Life</subject><subject>Regression analysis</subject><subject>Single nucleotide polymorphisms</subject><subject>Sports injuries</subject><subject>Tobacco</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkstv1DAQxiMEoqVw44wsceHAlomdh31CSwVtpSIqUbhaE2ey61ViL7aDVPjn8aoPtgj5YGvm933WPIriZQnHQih4ZzdT5DU0QgA8Kg7LivMFQNM-3nsfFM9i3ABwwWv1tDgQss6plh8Wv0_JUbKGfcdgMVnvIrOOfZ2joW2ynR1tumbJs6uA84Q78nPOjcTO3WYOliJD19_FLjFrcfJuxT4E_JXF6NiZXa0XlxQGHyZ0htgyrUdKFJ8XTwYcI724vY-Kb58-Xp2cLS6-nJ6fLC8WphJtWrRNL1Q51NgaWXe9gdoQ9LJEzgEr08pegmqx7HilFEglVK165EbxTjbKGHFUvL_x3c7dRL0hlwKOehvshOFae7T6YcbZtV75n7oE1SjZyOzw5tYh-B8zxaQnmxs0jujIz1ELKCuAVtZ1Rl__g278HFyuL1OQh5RnwP9SKxxJWzf4_LHZmeplKyWvJC931PF_qHx6mqzxjgab4w8Eb28EJvgYAw33RZagd9ui97cl46_2G3MP362H-AMTebrw</recordid><startdate>20240314</startdate><enddate>20240314</enddate><creator>Marques, Inês Soares</creator><creator>Tavares, Valéria</creator><creator>Vieira Neto, Beatriz</creator><creator>Lopes, Lucas Rafael</creator><creator>Goes, Rodrigo Araújo</creator><creator>Guimarães, João António Matheus</creator><creator>Perini, Jamila Alessandra</creator><creator>Medeiros, Rui</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3010-8373</orcidid><orcidid>https://orcid.org/0000-0003-3680-7757</orcidid><orcidid>https://orcid.org/0000-0002-2543-904X</orcidid><orcidid>https://orcid.org/0000-0002-5647-2248</orcidid><orcidid>https://orcid.org/0000-0002-7683-0698</orcidid><orcidid>https://orcid.org/0000-0002-5955-9904</orcidid></search><sort><creationdate>20240314</creationdate><title>Genetic Variations in Susceptibility to Traumatic Muscle Injuries and Muscle Pain among Brazilian High-Performance Athletes</title><author>Marques, Inês Soares ; Tavares, Valéria ; Vieira Neto, Beatriz ; Lopes, Lucas Rafael ; Goes, Rodrigo Araújo ; Guimarães, João António Matheus ; Perini, Jamila Alessandra ; Medeiros, Rui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-76d391f5a7c85bdc05ce0d81a220a4c78d8097a1b24990893959da2c92b869cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Actinin - genetics</topic><topic>Adrenergic receptors</topic><topic>Athletes</topic><topic>Brazil - epidemiology</topic><topic>Disease susceptibility</topic><topic>Exercise</topic><topic>Female</topic><topic>Fractures</topic><topic>Genetic aspects</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Injuries</topic><topic>Male</topic><topic>Muscle pain</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>Myalgia</topic><topic>Physical fitness</topic><topic>Political activity</topic><topic>Political aspects</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Proteins</topic><topic>Quality of Life</topic><topic>Regression analysis</topic><topic>Single nucleotide polymorphisms</topic><topic>Sports injuries</topic><topic>Tobacco</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marques, Inês Soares</creatorcontrib><creatorcontrib>Tavares, Valéria</creatorcontrib><creatorcontrib>Vieira Neto, Beatriz</creatorcontrib><creatorcontrib>Lopes, Lucas Rafael</creatorcontrib><creatorcontrib>Goes, Rodrigo Araújo</creatorcontrib><creatorcontrib>Guimarães, João António Matheus</creatorcontrib><creatorcontrib>Perini, Jamila Alessandra</creatorcontrib><creatorcontrib>Medeiros, Rui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marques, Inês Soares</au><au>Tavares, Valéria</au><au>Vieira Neto, Beatriz</au><au>Lopes, Lucas Rafael</au><au>Goes, Rodrigo Araújo</au><au>Guimarães, João António Matheus</au><au>Perini, Jamila Alessandra</au><au>Medeiros, Rui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Variations in Susceptibility to Traumatic Muscle Injuries and Muscle Pain among Brazilian High-Performance Athletes</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2024-03-14</date><risdate>2024</risdate><volume>25</volume><issue>6</issue><spage>3300</spage><pages>3300-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Traumatic muscle injuries (TMIs) and muscle pain (MP) negatively impact athletes' performance and quality of life. Both conditions have a complex pathophysiology involving the interplay between genetic and environmental factors. Yet, the existing data are scarce and controversial. To provide more insights, this study aimed to investigate the association of single-nucleotide polymorphisms (SNPs) previously linked to athletic status with TMI and MP after exercise among Brazilian high-performance athletes from different sports modalities (N = 345). The impact of important environmental determinants was also assessed. From the six evaluated SNPs (
rs1815739,
rs324420,
rs8192678,
rs1042713,
rs1799983, and
rs731236), none was significantly associated with TMI. Regarding MP after exercise,
rs1815739 (CC/CT vs. TT; adjusted odds ratio (aOR) = 1.90; 95% confidence interval (95%Cl), 1.01-3.57) and
rs324420 (AA vs. AC/CC; aOR = 2.30; 95%Cl, 1.08-4.91) were independent predictors according to multivariate binomial analyses adjusted for age (≥23 vs. <23 years), sex (male vs. female), and tobacco consumption (yes vs. no). External validation is warranted to assess the predictive value of
rs1815739 and
rs324420. This could have implications for prophylactic interventions to improve athletes' quality of life.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38542272</pmid><doi>10.3390/ijms25063300</doi><orcidid>https://orcid.org/0000-0003-3010-8373</orcidid><orcidid>https://orcid.org/0000-0003-3680-7757</orcidid><orcidid>https://orcid.org/0000-0002-2543-904X</orcidid><orcidid>https://orcid.org/0000-0002-5647-2248</orcidid><orcidid>https://orcid.org/0000-0002-7683-0698</orcidid><orcidid>https://orcid.org/0000-0002-5955-9904</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Actinin - genetics Adrenergic receptors Athletes Brazil - epidemiology Disease susceptibility Exercise Female Fractures Genetic aspects Genotype Genotype & phenotype Humans Injuries Male Muscle pain Muscles Musculoskeletal system Myalgia Physical fitness Political activity Political aspects Polymorphism, Single Nucleotide Proteins Quality of Life Regression analysis Single nucleotide polymorphisms Sports injuries Tobacco |
| title | Genetic Variations in Susceptibility to Traumatic Muscle Injuries and Muscle Pain among Brazilian High-Performance Athletes |
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