Type I interferon regulates interleukin-1beta and IL-18 production and secretion in human macrophages

Inflammasomes are immune complexes whose activation leads to the release of pro-inflammatory cytokines IL-18 and IL-1β. Type I IFNs play a role in fighting infection and stimulate the expression of IFN-stimulated genes (ISGs) involved in inflammation. Despite the importance of these cytokines in inf...

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Veröffentlicht in:	Life science alliance 2024-06, Vol.7 (6), p.e202302399
Hauptverfasser:	Díaz-Pino, Rodrigo, Rice, Gillian I, San Felipe, Diego, Pepanashvili, Tamar, Kasher, Paul R, Briggs, Tracy A, López-Castejón, Gloria
Format:	Artikel
Sprache:	eng
Schlagworte:	Caspase 1 - metabolism Cytokines - metabolism Humans Inflammasomes - metabolism Inflammation - metabolism Interferon Type I - metabolism Interleukin-18 - metabolism Interleukin-1beta - metabolism Macrophages - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
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