KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13

KCTD10 belongs to the KCTD (potassiumchannel tetramerization domain) family, many members of which are associated with neuropsychiatric disorders. However, the biological function underlying the association with brain disorders remains to be explored. Here, we reveal that Kctd10 is highly expressed...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-03, Vol.121 (12), p.e2315707121-e2315707121
Hauptverfasser:	Cheng, Jianbo, Wang, Zhen, Tang, Manpei, Zhang, Wen, Li, Guozhong, Tan, Senwei, Mu, Chenjun, Hu, Mengyuan, Zhang, Dan, Jia, Xiangbin, Wen, Yangxuan, Guo, Hui, Xu, Dan, Liu, Liang, Li, Jiada, Xia, Kun, Li, Faxiang, Duan, Ranhui, Xu, Zhiheng, Yuan, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animals Biological Sciences Brain Brain - metabolism Brain Diseases - genetics Disorders Mental disorders Mice Neural stem cells Neurodevelopmental disorders Neurodevelopmental Disorders - genetics Neurogenesis - genetics Neurons Neurons - metabolism Pathogenesis Potassium Channels, Voltage-Gated - metabolism Proteins Proteins - metabolism Ubiquitination
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