Principles and methods for transferring polygenic risk scores across global populations

Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait or disease and may become a valuable tool for advancing precision medicine. However, PRSs that are developed in populations of predominantly European genetic ancestries can increase health disparities due to p...

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Veröffentlicht in:	Nature reviews. Genetics 2024-01, Vol.25 (1), p.8-25
Hauptverfasser:	Kachuri, Linda, Chatterjee, Nilanjan, Hirbo, Jibril, Schaid, Daniel J., Martin, Iman, Kullo, Iftikhar J., Kenny, Eimear E., Pasaniuc, Bogdan, Witte, John S., Ge, Tian
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/48 631/208/2489/144 631/208/2489/1512 631/208/457/649 Accuracy Agriculture Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Cancer Research Disease Gene Function Genealogy Genetic diversity Genetic factors Genetic Predisposition to Disease Genetics Genome-Wide Association Study Genomes Human Genetics Humans Multifactorial Inheritance Polygenic inheritance Population Population genetics Precision Medicine Review Article Risk Factors
Online-Zugang:	Volltext
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