Association of abnormalities in electrocardiography and ultrasonic echocardiography with the occurrence of cardiovascular disease in patients with advanced chronic kidney disease
Background In patients with chronic kidney disease (CKD), the incidence of cardiovascular disease (CVD) increases with disease progression. CVD screening tests in those with CKD were researched to determine whether abnormalities observed in electrocardiography (ECG) and ultrasonic echocardiography (...
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| Veröffentlicht in: | Clinical and experimental nephrology 2024-04, Vol.28 (4), p.307-315 |
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| creator | Hirabayashi, Ken Fujii, Hideki Kono, Keiji Yamatani, Satoshi Shimizu, Mao Watanabe, Kentaro Sakamoto, Kazuo Goto, Shunsuke Nishi, Shinichi |
| description | Background
In patients with chronic kidney disease (CKD), the incidence of cardiovascular disease (CVD) increases with disease progression. CVD screening tests in those with CKD were researched to determine whether abnormalities observed in electrocardiography (ECG) and ultrasonic echocardiography (UCG) were risk factors associated with the development of CVD.
Methods
This study included 604 patients with CKD G4 and G5, for whom both ECG and UCG were performed. They were divided into four groups: those without ECG- and UCG-indicated abnormalities (group A, n = 333), with only ECG abnormalities (group B, n = 106), with only UCG abnormalities (group C, n = 75), and with both ECG and UCG abnormalities (group D, n = 90). Multivariate analysis using Cox regression analysis of the occurrence of CVD was performed during a follow-up period.
Results
During the observation period, 124 patients had clinical events. Among them, 45 patients (13.5%) were in Group A, 25 patients (23.6%) in Group B, 19 patients (25.3%) in Group C, and 35 patients (38.9%) in Group D, respectively. CVD event occurrence was highest in Group D. The results of the multivariate analysis also showed that the CVD event rates were significantly higher in Group C (HR: 2.96,
P
= |
| doi_str_mv | 10.1007/s10157-023-02437-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10954921</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2969271358</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-a5d71fc1e120f00f418c911622d36e706ad8f835292a602e01495ce5637b065b3</originalsourceid><addsrcrecordid>eNp9ks9u1DAQxiMEoqXwAhyQJS5cAmM7juMTqir-SZW4wNny2pONS9Ze7GSrfS2eEKdpC-XAwbKt-X3fzEhfVb2k8JYCyHeZAhWyBsbLabisu0fVKV0eUir1uLx5w2oqBT2pnuV8BQCdEuppdcI72tDyOa1-neccrTeTj4HEnphNiGlnRj95zMQHgiPaKUVrkvNxm8x-OBITHJnHKZkcg7cE7fCwfu2ngUwDkmjtnBIGi4v3yhxMtvNoEnE-o8m4NNmX_himvCqNO5giccQO6abBD-8CHu8Ez6snvRkzvri9z6rvHz98u_hcX3799OXi_LK2jYSpNsJJ2luKlEEP0De0s4rSljHHW5TQGtf1HRdMMdMCQ6CNEhZFy-UGWrHhZ9X71Xc_b3bobBkwmVHvk9-ZdNTReP2wEvygt_GgKSjRKEaLw5tbhxR_zpgnvfPZ4jiagHHOmikQgrUth4K-_ge9inMKZb9CtYpJykVXKLZSNsWcE_b301DQSyb0mgldMqFvMqEX0au_97iX3IWgAHwFcimFLaY_vf9j-xuUf8dX</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2969271358</pqid></control><display><type>article</type><title>Association of abnormalities in electrocardiography and ultrasonic echocardiography with the occurrence of cardiovascular disease in patients with advanced chronic kidney disease</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Hirabayashi, Ken ; Fujii, Hideki ; Kono, Keiji ; Yamatani, Satoshi ; Shimizu, Mao ; Watanabe, Kentaro ; Sakamoto, Kazuo ; Goto, Shunsuke ; Nishi, Shinichi</creator><creatorcontrib>Hirabayashi, Ken ; Fujii, Hideki ; Kono, Keiji ; Yamatani, Satoshi ; Shimizu, Mao ; Watanabe, Kentaro ; Sakamoto, Kazuo ; Goto, Shunsuke ; Nishi, Shinichi</creatorcontrib><description>Background
In patients with chronic kidney disease (CKD), the incidence of cardiovascular disease (CVD) increases with disease progression. CVD screening tests in those with CKD were researched to determine whether abnormalities observed in electrocardiography (ECG) and ultrasonic echocardiography (UCG) were risk factors associated with the development of CVD.
Methods
This study included 604 patients with CKD G4 and G5, for whom both ECG and UCG were performed. They were divided into four groups: those without ECG- and UCG-indicated abnormalities (group A, n = 333), with only ECG abnormalities (group B, n = 106), with only UCG abnormalities (group C, n = 75), and with both ECG and UCG abnormalities (group D, n = 90). Multivariate analysis using Cox regression analysis of the occurrence of CVD was performed during a follow-up period.
Results
During the observation period, 124 patients had clinical events. Among them, 45 patients (13.5%) were in Group A, 25 patients (23.6%) in Group B, 19 patients (25.3%) in Group C, and 35 patients (38.9%) in Group D, respectively. CVD event occurrence was highest in Group D. The results of the multivariate analysis also showed that the CVD event rates were significantly higher in Group C (HR: 2.96,
P
= < .001) and D (HR: 4.22,
P
< .001) than in Group A.
Conclusion
In patients with advanced CKD, there was a significant correlation of ECG and UCG abnormalities with CVD events. Additionally, those having both types of abnormalities may have a higher risk of coronary artery disease than other groups.</description><identifier>ISSN: 1342-1751</identifier><identifier>ISSN: 1437-7799</identifier><identifier>EISSN: 1437-7799</identifier><identifier>DOI: 10.1007/s10157-023-02437-8</identifier><identifier>PMID: 38141089</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Coronary artery disease ; Echocardiography ; Echocardiography - adverse effects ; EKG ; Electrocardiography ; Electrocardiography - adverse effects ; Heart diseases ; Humans ; Kidney diseases ; Medicine ; Medicine & Public Health ; Multivariate analysis ; Nephrology ; Original ; Original Article ; Renal Insufficiency, Chronic - complications ; Risk Factors ; Ultrasonics ; Urology</subject><ispartof>Clinical and experimental nephrology, 2024-04, Vol.28 (4), p.307-315</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c470t-a5d71fc1e120f00f418c911622d36e706ad8f835292a602e01495ce5637b065b3</cites><orcidid>0000-0001-7610-1068</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10157-023-02437-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10157-023-02437-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38141089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirabayashi, Ken</creatorcontrib><creatorcontrib>Fujii, Hideki</creatorcontrib><creatorcontrib>Kono, Keiji</creatorcontrib><creatorcontrib>Yamatani, Satoshi</creatorcontrib><creatorcontrib>Shimizu, Mao</creatorcontrib><creatorcontrib>Watanabe, Kentaro</creatorcontrib><creatorcontrib>Sakamoto, Kazuo</creatorcontrib><creatorcontrib>Goto, Shunsuke</creatorcontrib><creatorcontrib>Nishi, Shinichi</creatorcontrib><title>Association of abnormalities in electrocardiography and ultrasonic echocardiography with the occurrence of cardiovascular disease in patients with advanced chronic kidney disease</title><title>Clinical and experimental nephrology</title><addtitle>Clin Exp Nephrol</addtitle><addtitle>Clin Exp Nephrol</addtitle><description>Background
In patients with chronic kidney disease (CKD), the incidence of cardiovascular disease (CVD) increases with disease progression. CVD screening tests in those with CKD were researched to determine whether abnormalities observed in electrocardiography (ECG) and ultrasonic echocardiography (UCG) were risk factors associated with the development of CVD.
Methods
This study included 604 patients with CKD G4 and G5, for whom both ECG and UCG were performed. They were divided into four groups: those without ECG- and UCG-indicated abnormalities (group A, n = 333), with only ECG abnormalities (group B, n = 106), with only UCG abnormalities (group C, n = 75), and with both ECG and UCG abnormalities (group D, n = 90). Multivariate analysis using Cox regression analysis of the occurrence of CVD was performed during a follow-up period.
Results
During the observation period, 124 patients had clinical events. Among them, 45 patients (13.5%) were in Group A, 25 patients (23.6%) in Group B, 19 patients (25.3%) in Group C, and 35 patients (38.9%) in Group D, respectively. CVD event occurrence was highest in Group D. The results of the multivariate analysis also showed that the CVD event rates were significantly higher in Group C (HR: 2.96,
P
= < .001) and D (HR: 4.22,
P
< .001) than in Group A.
Conclusion
In patients with advanced CKD, there was a significant correlation of ECG and UCG abnormalities with CVD events. Additionally, those having both types of abnormalities may have a higher risk of coronary artery disease than other groups.</description><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Coronary artery disease</subject><subject>Echocardiography</subject><subject>Echocardiography - adverse effects</subject><subject>EKG</subject><subject>Electrocardiography</subject><subject>Electrocardiography - adverse effects</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multivariate analysis</subject><subject>Nephrology</subject><subject>Original</subject><subject>Original Article</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Risk Factors</subject><subject>Ultrasonics</subject><subject>Urology</subject><issn>1342-1751</issn><issn>1437-7799</issn><issn>1437-7799</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9ks9u1DAQxiMEoqXwAhyQJS5cAmM7juMTqir-SZW4wNny2pONS9Ze7GSrfS2eEKdpC-XAwbKt-X3fzEhfVb2k8JYCyHeZAhWyBsbLabisu0fVKV0eUir1uLx5w2oqBT2pnuV8BQCdEuppdcI72tDyOa1-neccrTeTj4HEnphNiGlnRj95zMQHgiPaKUVrkvNxm8x-OBITHJnHKZkcg7cE7fCwfu2ngUwDkmjtnBIGi4v3yhxMtvNoEnE-o8m4NNmX_himvCqNO5giccQO6abBD-8CHu8Ez6snvRkzvri9z6rvHz98u_hcX3799OXi_LK2jYSpNsJJ2luKlEEP0De0s4rSljHHW5TQGtf1HRdMMdMCQ6CNEhZFy-UGWrHhZ9X71Xc_b3bobBkwmVHvk9-ZdNTReP2wEvygt_GgKSjRKEaLw5tbhxR_zpgnvfPZ4jiagHHOmikQgrUth4K-_ge9inMKZb9CtYpJykVXKLZSNsWcE_b301DQSyb0mgldMqFvMqEX0au_97iX3IWgAHwFcimFLaY_vf9j-xuUf8dX</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Hirabayashi, Ken</creator><creator>Fujii, Hideki</creator><creator>Kono, Keiji</creator><creator>Yamatani, Satoshi</creator><creator>Shimizu, Mao</creator><creator>Watanabe, Kentaro</creator><creator>Sakamoto, Kazuo</creator><creator>Goto, Shunsuke</creator><creator>Nishi, Shinichi</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7610-1068</orcidid></search><sort><creationdate>20240401</creationdate><title>Association of abnormalities in electrocardiography and ultrasonic echocardiography with the occurrence of cardiovascular disease in patients with advanced chronic kidney disease</title><author>Hirabayashi, Ken ; Fujii, Hideki ; Kono, Keiji ; Yamatani, Satoshi ; Shimizu, Mao ; Watanabe, Kentaro ; Sakamoto, Kazuo ; Goto, Shunsuke ; Nishi, Shinichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-a5d71fc1e120f00f418c911622d36e706ad8f835292a602e01495ce5637b065b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Coronary artery disease</topic><topic>Echocardiography</topic><topic>Echocardiography - adverse effects</topic><topic>EKG</topic><topic>Electrocardiography</topic><topic>Electrocardiography - adverse effects</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multivariate analysis</topic><topic>Nephrology</topic><topic>Original</topic><topic>Original Article</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Risk Factors</topic><topic>Ultrasonics</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirabayashi, Ken</creatorcontrib><creatorcontrib>Fujii, Hideki</creatorcontrib><creatorcontrib>Kono, Keiji</creatorcontrib><creatorcontrib>Yamatani, Satoshi</creatorcontrib><creatorcontrib>Shimizu, Mao</creatorcontrib><creatorcontrib>Watanabe, Kentaro</creatorcontrib><creatorcontrib>Sakamoto, Kazuo</creatorcontrib><creatorcontrib>Goto, Shunsuke</creatorcontrib><creatorcontrib>Nishi, Shinichi</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirabayashi, Ken</au><au>Fujii, Hideki</au><au>Kono, Keiji</au><au>Yamatani, Satoshi</au><au>Shimizu, Mao</au><au>Watanabe, Kentaro</au><au>Sakamoto, Kazuo</au><au>Goto, Shunsuke</au><au>Nishi, Shinichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of abnormalities in electrocardiography and ultrasonic echocardiography with the occurrence of cardiovascular disease in patients with advanced chronic kidney disease</atitle><jtitle>Clinical and experimental nephrology</jtitle><stitle>Clin Exp Nephrol</stitle><addtitle>Clin Exp Nephrol</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>28</volume><issue>4</issue><spage>307</spage><epage>315</epage><pages>307-315</pages><issn>1342-1751</issn><issn>1437-7799</issn><eissn>1437-7799</eissn><abstract>Background
In patients with chronic kidney disease (CKD), the incidence of cardiovascular disease (CVD) increases with disease progression. CVD screening tests in those with CKD were researched to determine whether abnormalities observed in electrocardiography (ECG) and ultrasonic echocardiography (UCG) were risk factors associated with the development of CVD.
Methods
This study included 604 patients with CKD G4 and G5, for whom both ECG and UCG were performed. They were divided into four groups: those without ECG- and UCG-indicated abnormalities (group A, n = 333), with only ECG abnormalities (group B, n = 106), with only UCG abnormalities (group C, n = 75), and with both ECG and UCG abnormalities (group D, n = 90). Multivariate analysis using Cox regression analysis of the occurrence of CVD was performed during a follow-up period.
Results
During the observation period, 124 patients had clinical events. Among them, 45 patients (13.5%) were in Group A, 25 patients (23.6%) in Group B, 19 patients (25.3%) in Group C, and 35 patients (38.9%) in Group D, respectively. CVD event occurrence was highest in Group D. The results of the multivariate analysis also showed that the CVD event rates were significantly higher in Group C (HR: 2.96,
P
= < .001) and D (HR: 4.22,
P
< .001) than in Group A.
Conclusion
In patients with advanced CKD, there was a significant correlation of ECG and UCG abnormalities with CVD events. Additionally, those having both types of abnormalities may have a higher risk of coronary artery disease than other groups.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>38141089</pmid><doi>10.1007/s10157-023-02437-8</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7610-1068</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Coronary artery disease Echocardiography Echocardiography - adverse effects EKG Electrocardiography Electrocardiography - adverse effects Heart diseases Humans Kidney diseases Medicine Medicine & Public Health Multivariate analysis Nephrology Original Original Article Renal Insufficiency, Chronic - complications Risk Factors Ultrasonics Urology |
| title | Association of abnormalities in electrocardiography and ultrasonic echocardiography with the occurrence of cardiovascular disease in patients with advanced chronic kidney disease |
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