A concerted neuron–astrocyte program declines in ageing and schizophrenia

Human brains vary across people and over time; such variation is not yet understood in cellular terms. Here we describe a relationship between people’s cortical neurons and cortical astrocytes. We used single-nucleus RNA sequencing to analyse the prefrontal cortex of 191 human donors aged 22–97 year...

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Veröffentlicht in:	Nature (London) 2024-03, Vol.627 (8004), p.604-611
Hauptverfasser:	Ling, Emi, Nemesh, James, Goldman, Melissa, Kamitaki, Nolan, Reed, Nora, Handsaker, Robert E., Genovese, Giulio, Vogelgsang, Jonathan S., Gerges, Sherif, Kashin, Seva, Ghosh, Sulagna, Esposito, John M., Morris, Kiely, Meyer, Daniel, Lutservitz, Alyssa, Mullally, Christopher D., Wysoker, Alec, Spina, Liv, Neumann, Anna, Hogan, Marina, Ichihara, Kiku, Berretta, Sabina, McCarroll, Steven A.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/39 45/23 45/91 631/208/212 631/337/2019 631/378/1689/1799 631/378/2611 631/378/340 Adult Age Aged Aged, 80 and over Aging Aging - metabolism Aging - pathology Astrocytes Astrocytes - cytology Astrocytes - metabolism Astrocytes - pathology Biosynthesis Brain Cholesterol Cholesterol - metabolism Cognition Cognitive ability Factor analysis GABAergic Neurons - metabolism Gene expression Gene sequencing Genes Genetic Predisposition to Disease Glutamatergic transmission Glutamine - metabolism Health Humanities and Social Sciences Humans Individuality Mental disorders Middle Aged multidisciplinary Neural Inhibition Neuronal Plasticity Neurons Neurons - cytology Neurons - metabolism Neurons - pathology Prefrontal cortex Prefrontal Cortex - cytology Prefrontal Cortex - metabolism Prefrontal Cortex - pathology Risk factors Schizophrenia Schizophrenia - genetics Schizophrenia - metabolism Schizophrenia - pathology Science Science (multidisciplinary) Single-Cell Gene Expression Analysis Synapses - genetics Synapses - metabolism Synapses - pathology Synaptic membranes Synaptic Membranes - chemistry Synaptic Membranes - metabolism Young Adult γ-Aminobutyric acid
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