Termination of convulsion seizures by destabilizing and perturbing seizure memory engrams

Epileptogenesis, arising from alterations in synaptic strength, shares mechanistic and phenotypic parallels with memory formation. However, direct evidence supporting the existence of seizure memory remains scarce. Leveraging a conditioned seizure memory (CSM) paradigm, we found that CSM enabled the...

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Veröffentlicht in:	Science advances 2024-03, Vol.10 (12), p.eadk9484-eadk9484
Hauptverfasser:	Lai, Shirong, Zhang, Libo, Tu, Xinyu, Ma, Xinyue, Song, Yujing, Cao, Kexin, Li, Miaomiao, Meng, Jihong, Shi, Yiqiang, Wu, Qing, Yang, Chen, Lan, Zifan, Lau, Chunyue Geoffrey, Shi, Jie, Ma, Weining, Li, Shaoyi, Xue, Yan-Xue, Huang, Zhuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Electroencephalography Epilepsy Humans Mammals Neuroscience SciAdv r-articles Seizures - etiology Sirolimus TOR Serine-Threonine Kinases
Online-Zugang:	Volltext
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