hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen‐induced transcriptional response in prostate cancer

Background Activation and regulation of androgen receptor (AR) signaling and the DNA damage response impact the prostate cancer (PCa) treatment modalities of androgen deprivation therapy (ADT) and radiotherapy. Here, we have evaluated a role for human single‐strand binding protein 1 (hSSB1/NABP2) in...

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Veröffentlicht in:	The Prostate 2023-05, Vol.83 (7), p.628-640
Hauptverfasser:	Adams, Mark N., Croft, Laura V., Urquhart, Aaron, Saleem, Mohamed Ashick Mohamed, Rockstroh, Anja, Duijf, Pascal H. G., Thomas, Patrick B., Ferguson, Genevieve P., Najib, Idris Mohd, Shah, Esha T., Bolderson, Emma, Nagaraj, Shivashankar, Williams, Elizabeth D., Nelson, Colleen C., O'Byrne, Kenneth J., Richard, Derek J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - pharmacology androgen receptor Androgen receptors Androgens Androgens - metabolism Cancer therapies Cell cycle Cell Line, Tumor Deoxyribonucleic acid DNA DNA Damage DNA microarrays DNA Repair DNA-Binding Proteins - metabolism DNA-directed RNA polymerase Genomes Genomic Instability Homologous recombination hSSB1/NABP2 Humans Ionizing radiation Male Mitochondrial Proteins - metabolism Original p53 Protein Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Proteins radiation Radiation therapy Receptors, Androgen - genetics RNA polymerase
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