Subclassification of epithelioid sarcoma with potential therapeutic impact

Epithelioid sarcoma is a rare and aggressive mesenchymal tumour, the genetic hallmark of which is the loss of expression of SMARCB1, a key member of the SWItch/Sucrose Non‐Fermentable (SWI/SNF) chromatin remodelling complex. Hampered by its rarity, epithelioid sarcoma has received little research at...

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Veröffentlicht in:	The Journal of pathology 2023-08, Vol.260 (4), p.368-375
Hauptverfasser:	Haefliger, Simon, Chervova, Olga, Davies, Christopher, Nottley, Steven, Hargreaves, Steven, Sumathi, Vaiyapuri P, Amary, Fernanda, Tirabosco, Roberto, Pillay, Nischalan, Beck, Stephan, Flanagan, Adrienne M, Lyskjær, Iben
Format:	Artikel
Sprache:	eng
Schlagworte:	Brief Report CD8 antigen Chromatin remodeling Chromosomal Proteins, Non-Histone - genetics DNA methylation profile DNA-Binding Proteins - genetics epithelioid sarcoma Gene expression Humans immune cell deconvolution Immune checkpoint inhibitors Immunohistochemistry Immunotherapy Lymphocytes Macrophages Peripheral nerves Rhabdoid Tumor - genetics Rhabdoid Tumor - metabolism Rhabdoid Tumor - therapy Sarcoma Sarcoma - genetics Sarcoma - metabolism Sarcoma - therapy SMARCB1 SMARCB1 Protein - genetics SMARCB1‐deficient tumours Sucrose Tumors
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