The effect of aspirin and eicosapentaenoic acid on urinary biomarkers of prostaglandin E2 synthesis and platelet activation in participants of the seAFOod polyp prevention trial

Urinary prostaglandin (PG) E metabolite (PGE‐M) and 11‐dehydro (d)‐thromboxane (TX) B2 are biomarkers of cyclooxygenase‐dependent prostanoid synthesis. We investigated (1) the effect of aspirin 300 mg daily and eicosapentaenoic acid (EPA) 2000 mg daily, alone and in combination, on urinary biomarker...

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Veröffentlicht in:	International journal of cancer 2024-03, Vol.154 (5), p.873-885
Hauptverfasser:	Sun, Ge, Fuller, Harriett, Fenton, Hayley, Race, Amanda D, Downing, Amy, Williams, Elizabeth A, Rees, Colin J, Brown, Louise C, Loadman, Paul M, Hull, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspirin Biomarkers Cancer Carcinogenesis Clinical trials Colorectal cancer Colorectal carcinoma Drug therapy Eicosapentaenoic acid Health risks Liquid chromatography Mass spectroscopy Medical research Placebos Platelets Polyps Prostaglandin E2 Prostaglandin endoperoxide synthase Regression analysis Seafood
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