CREB1 activation promotes human papillomavirus oncogene expression and cervical cancer cell transformation

Human papillomaviruses (HPVs) infect the oral and anogenital mucosa and can cause cancer. The high‐risk (HR)‐HPV oncoproteins, E6 and E7, hijack cellular factors to promote cell proliferation, delay differentiation and induce genomic instability, thus predisposing infected cells to malignant transfo...

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Veröffentlicht in:	Journal of medical virology 2023-08, Vol.95 (8), p.e29025-n/a
Hauptverfasser:	Li, Yigen, Patterson, Molly R., Morgan, Ethan L., Wasson, Christopher W., Ryder, Emma L., Barba‐Moreno, Diego, Scarth, James A., Wang, Miao, Macdonald, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Anogenital Cancer Cell differentiation Cell growth Cell proliferation Cervical cancer Control theory CREB1 Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - genetics Epithelial-Mesenchymal Transition Feedback loops Female Genomic instability Health risks HPV Human papillomavirus Human Papillomavirus Viruses Humans Keratinocytes Life cycle analysis MAP kinase miRNA miR‐203a Oncogene Proteins, Viral - genetics Oncogenes Oncoproteins Papillomaviridae Papillomavirus E7 Proteins - genetics Papillomavirus Infections Phosphorylation Positive feedback Repressor Proteins - genetics Ribonucleic acid RNA Tumor cell lines Tumor suppressor genes Uterine Cervical Neoplasms Virology
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