Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease

The assessment of deep brain stimulation (DBS) as a therapeutic alternative for treating Alzheimer disease (AD) is ongoing. We aimed to determine the effects of intracranial self-stimulation at the medial forebrain bundle (MFB-ICSS) on spatial memory, neurodegeneration, and serum expression of micro...

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Veröffentlicht in:	Journal of psychiatry & neuroscience 2024-03, Vol.49 (2), p.E96-E108
Hauptverfasser:	Riberas-Sánchez, Andrea, Puig-Parnau, Irene, Vila-Solés, Laia, Garcia-Brito, Soleil, Aldavert-Vera, Laura, Segura-Torres, Pilar, Huguet, Gemma, Kádár, Elisabet
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Alzheimer Disease - therapy Alzheimer's disease Amyloid Animals Biomarkers Brain stimulation Care and treatment Deep brain stimulation Dentate gyrus Dosage and administration Electrodes Experiments Forebrain Health aspects Hippocampus Intracranial self-stimulation Male Maze Learning Medial forebrain bundle Memory Methods MicroRNA MicroRNAs MicroRNAs - genetics miRNA Neurodegeneration Neurodegenerative diseases Neurons Physiological aspects Proteins Rats Rats, Wistar Research Paper Reverse transcription Self Stimulation - physiology Self-stimulation Serum levels SIRT1 protein Sirtuin 1 - pharmacology Spatial ability Spatial discrimination learning Spatial Learning Spatial memory Streptozocin Streptozocin - toxicity Tau protein
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