Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation

More than 50% of human tumors display hyperactivation of the serine/threonine kinase AKT. Despite evidence of clinical efficacy, the therapeutic window of the current generation of AKT inhibitors could be improved. Here, we report the development of a second-generation AKT degrader, INY-05-040, whic...

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Veröffentlicht in:	Science signaling 2024-02, Vol.17 (825), p.eadf2670-eadf2670
Hauptverfasser:	Erickson, Emily C, You, Inchul, Perry, Grace, Dugourd, Aurelien, Donovan, Katherine A, Crafter, Claire, Johannes, Jeffrey W, Williamson, Stuart, Moss, Jennifer I, Ros, Susana, Ziegler, Robert E, Barry, Simon T, Fischer, Eric S, Gray, Nathanael S, Madsen, Ralitsa R, Toker, Alex
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Biomarkers Breast cancer Degradation Kinases MAP kinase Proteasomes Tumor cell lines
Online-Zugang:	Volltext
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