Prevalence of Increased QTc Dispersion Among Hypertensive Patients and Its Correlation to Clinical Risk Factors: A Hospital-Based Case-Control Study
Background In Ghana and other sub-Saharan African countries, hypertension (HTN) prevalence is rapidly increasing. Hypertensive left ventricular hypertrophy (LVH) is associated with excess fibrous tissue deposition throughout the myocardium. This could lead to ventricular arrhythmias and sudden cardi...
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| description | Background In Ghana and other sub-Saharan African countries, hypertension (HTN) prevalence is rapidly increasing. Hypertensive left ventricular hypertrophy (LVH) is associated with excess fibrous tissue deposition throughout the myocardium. This could lead to ventricular arrhythmias and sudden cardiac death. Increased corrected QT dispersion (QTcd) can cause ventricular repolarization and be used to identify patients at risk of ventricular tachyarrhythmia. The measurement of increased QTcd among hypertensive patients is a simple screening tool to stratify patients at cardiovascular risk. Methods A case-control hospital-based study was conducted on 200 consecutive hypertensive patients. Age- and sex-matched control groups of 200 normotensive individuals who gave informed consent were also recruited. The baseline clinical and demographic characteristics of participants were acquired using structured questionnaires. A physical examination and a resting 12-lead ECG were performed. Increased QTcd and LVH were determined. Results The mean age of hypertensive patients was 50.99±6.73 and 48.19±7.17 for the controls (p-value 0.63). The study population was predominantly female (1:2.4 male:female ratio). Higher mean values for QTcd and LVH (Sokolow-Lyon) were observed among hypertensive patients compared to controls. The prevalence of increased QTcd was 45.0% among hypertensive patients compared to 16.5% in controls (χ
=38.14, p-value |
| doi_str_mv | 10.7759/cureus.56423 |
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=38.14, p-value <0.0000001, odds ratio = 4.14). Conclusion Increased QTcd is prevalent among hypertensive Ghanaians. Its measurement can be an effective non-invasive screening tool to risk-stratify hypertensive patients.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.56423</identifier><identifier>PMID: 38505141</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Cardiac arrhythmia ; Cardiology ; Cardiovascular disease ; Developing countries ; Divorce ; Epidemiology/Public Health ; Females ; Heart rate ; Hypertension ; Internal Medicine ; LDCs ; Morphology ; Mortality ; Muslims ; Sociodemographics ; Teaching hospitals ; Vocational education</subject><ispartof>Curēus (Palo Alto, CA), 2024-03, Vol.16 (3), p.e56423-e56423</ispartof><rights>Copyright © 2024, Minkah MD FWACP et al.</rights><rights>Copyright © 2024, Minkah MD FWACP et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2024, Minkah MD FWACP et al. 2024 Minkah MD FWACP et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2153-d6b5befd2d7d32bce39afda35451ad7c32b5b1c3888d618d6a61003b2066c4b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948943/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948943/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38505141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Minkah Md Fwacp, Daniel Ohemeng</creatorcontrib><creatorcontrib>Owusu, Isaac K</creatorcontrib><creatorcontrib>Kokuro, Collins</creatorcontrib><creatorcontrib>Norman, Betty R</creatorcontrib><creatorcontrib>Arthur, Joshua A</creatorcontrib><creatorcontrib>Ogyefo, Isaac N</creatorcontrib><creatorcontrib>Kweki, Anthony G</creatorcontrib><title>Prevalence of Increased QTc Dispersion Among Hypertensive Patients and Its Correlation to Clinical Risk Factors: A Hospital-Based Case-Control Study</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Background In Ghana and other sub-Saharan African countries, hypertension (HTN) prevalence is rapidly increasing. Hypertensive left ventricular hypertrophy (LVH) is associated with excess fibrous tissue deposition throughout the myocardium. This could lead to ventricular arrhythmias and sudden cardiac death. Increased corrected QT dispersion (QTcd) can cause ventricular repolarization and be used to identify patients at risk of ventricular tachyarrhythmia. The measurement of increased QTcd among hypertensive patients is a simple screening tool to stratify patients at cardiovascular risk. Methods A case-control hospital-based study was conducted on 200 consecutive hypertensive patients. Age- and sex-matched control groups of 200 normotensive individuals who gave informed consent were also recruited. The baseline clinical and demographic characteristics of participants were acquired using structured questionnaires. A physical examination and a resting 12-lead ECG were performed. Increased QTcd and LVH were determined. Results The mean age of hypertensive patients was 50.99±6.73 and 48.19±7.17 for the controls (p-value 0.63). The study population was predominantly female (1:2.4 male:female ratio). Higher mean values for QTcd and LVH (Sokolow-Lyon) were observed among hypertensive patients compared to controls. The prevalence of increased QTcd was 45.0% among hypertensive patients compared to 16.5% in controls (χ
=38.14, p-value <0.0000001, odds ratio = 4.14). Conclusion Increased QTcd is prevalent among hypertensive Ghanaians. Its measurement can be an effective non-invasive screening tool to risk-stratify hypertensive patients.</description><subject>Cardiac arrhythmia</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Developing countries</subject><subject>Divorce</subject><subject>Epidemiology/Public Health</subject><subject>Females</subject><subject>Heart rate</subject><subject>Hypertension</subject><subject>Internal Medicine</subject><subject>LDCs</subject><subject>Morphology</subject><subject>Mortality</subject><subject>Muslims</subject><subject>Sociodemographics</subject><subject>Teaching hospitals</subject><subject>Vocational education</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkcFvFCEUxonR2Kb25tmQePHgVBiGGcaLWcfW3aSJVeuZMPCmUlnYArPJ_h_-wcVubaoHeI_HLx98-RB6SclJ1_H-nZ4jzOmEt03NnqDDmraiElQ0Tx_1B-g4pWtCCCVdTTryHB0wwQmnDT1Evy8ibJUDrwGHCa-8jqASGPz1UuNPNm0gJhs8XqyDv8LLXTln8MluAV-obMHnhJU3eFXqEGIEV6aFzwEPznqrlcPfbPqFz5TOIab3eIGXIW1sVq76ePfSUPZqCD7H4PD3PJvdC_RsUi7B8X09Qj_OTi-HZXX-5fNqWJxXuqacVaYd-QiTqU1nWD1qYL2ajGK84VSZTpcZH6lmQgjT0rJUSwlhY03aVjdjx47Qh73uZh7XYHRxE5WTm2jXKu5kUFb-e-PtT3kVtpKSvhF9w4rCm3uFGG5mSFmubdLgnPIQ5iTrvqs70tJeFPT1f-h1mKMv_iQjJRfOKeeFerundAwpRZgefkOJ_BO53Ecu7yIv-KvHDh7gvwGzW9BOqmo</recordid><startdate>20240318</startdate><enddate>20240318</enddate><creator>Minkah Md Fwacp, Daniel Ohemeng</creator><creator>Owusu, Isaac K</creator><creator>Kokuro, Collins</creator><creator>Norman, Betty R</creator><creator>Arthur, Joshua A</creator><creator>Ogyefo, Isaac N</creator><creator>Kweki, Anthony G</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240318</creationdate><title>Prevalence of Increased QTc Dispersion Among Hypertensive Patients and Its Correlation to Clinical Risk Factors: A Hospital-Based Case-Control Study</title><author>Minkah Md Fwacp, Daniel Ohemeng ; Owusu, Isaac K ; Kokuro, Collins ; Norman, Betty R ; Arthur, Joshua A ; Ogyefo, Isaac N ; Kweki, Anthony G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2153-d6b5befd2d7d32bce39afda35451ad7c32b5b1c3888d618d6a61003b2066c4b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cardiac arrhythmia</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Developing countries</topic><topic>Divorce</topic><topic>Epidemiology/Public Health</topic><topic>Females</topic><topic>Heart rate</topic><topic>Hypertension</topic><topic>Internal Medicine</topic><topic>LDCs</topic><topic>Morphology</topic><topic>Mortality</topic><topic>Muslims</topic><topic>Sociodemographics</topic><topic>Teaching hospitals</topic><topic>Vocational education</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Minkah Md Fwacp, Daniel Ohemeng</creatorcontrib><creatorcontrib>Owusu, Isaac K</creatorcontrib><creatorcontrib>Kokuro, Collins</creatorcontrib><creatorcontrib>Norman, Betty R</creatorcontrib><creatorcontrib>Arthur, Joshua A</creatorcontrib><creatorcontrib>Ogyefo, Isaac N</creatorcontrib><creatorcontrib>Kweki, Anthony G</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minkah Md Fwacp, Daniel Ohemeng</au><au>Owusu, Isaac K</au><au>Kokuro, Collins</au><au>Norman, Betty R</au><au>Arthur, Joshua A</au><au>Ogyefo, Isaac N</au><au>Kweki, Anthony G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of Increased QTc Dispersion Among Hypertensive Patients and Its Correlation to Clinical Risk Factors: A Hospital-Based Case-Control Study</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2024-03-18</date><risdate>2024</risdate><volume>16</volume><issue>3</issue><spage>e56423</spage><epage>e56423</epage><pages>e56423-e56423</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Background In Ghana and other sub-Saharan African countries, hypertension (HTN) prevalence is rapidly increasing. Hypertensive left ventricular hypertrophy (LVH) is associated with excess fibrous tissue deposition throughout the myocardium. This could lead to ventricular arrhythmias and sudden cardiac death. Increased corrected QT dispersion (QTcd) can cause ventricular repolarization and be used to identify patients at risk of ventricular tachyarrhythmia. The measurement of increased QTcd among hypertensive patients is a simple screening tool to stratify patients at cardiovascular risk. Methods A case-control hospital-based study was conducted on 200 consecutive hypertensive patients. Age- and sex-matched control groups of 200 normotensive individuals who gave informed consent were also recruited. The baseline clinical and demographic characteristics of participants were acquired using structured questionnaires. A physical examination and a resting 12-lead ECG were performed. Increased QTcd and LVH were determined. Results The mean age of hypertensive patients was 50.99±6.73 and 48.19±7.17 for the controls (p-value 0.63). The study population was predominantly female (1:2.4 male:female ratio). Higher mean values for QTcd and LVH (Sokolow-Lyon) were observed among hypertensive patients compared to controls. The prevalence of increased QTcd was 45.0% among hypertensive patients compared to 16.5% in controls (χ
=38.14, p-value <0.0000001, odds ratio = 4.14). Conclusion Increased QTcd is prevalent among hypertensive Ghanaians. Its measurement can be an effective non-invasive screening tool to risk-stratify hypertensive patients.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>38505141</pmid><doi>10.7759/cureus.56423</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Cardiac arrhythmia Cardiology Cardiovascular disease Developing countries Divorce Epidemiology/Public Health Females Heart rate Hypertension Internal Medicine LDCs Morphology Mortality Muslims Sociodemographics Teaching hospitals Vocational education |
| title | Prevalence of Increased QTc Dispersion Among Hypertensive Patients and Its Correlation to Clinical Risk Factors: A Hospital-Based Case-Control Study |
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