Iron status in Swiss adolescents with paediatric major depressive disorder and healthy controls: a matched case–control study
Purpose Depression is associated with low-grade systemic inflammation and impaired intestinal function, both of which may reduce dietary iron absorption. Low iron status has been associated with depression in adults and adolescents. In Swiss adolescents, we determined the associations between paedia...
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| Veröffentlicht in: | European journal of nutrition 2024-04, Vol.63 (3), p.951-963 |
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| creator | Osuna, Ester Baumgartner, Jeannine Wunderlin, Olivia Emery, Sophie Albermann, Mona Baumgartner, Noemi Schmeck, Klaus Walitza, Susanne Strumberger, Michael Hersberger, Martin Zimmermann, Michael B. Häberling, Isabelle Berger, Gregor Herter-Aeberli, Isabelle |
| description | Purpose
Depression is associated with low-grade systemic inflammation and impaired intestinal function, both of which may reduce dietary iron absorption. Low iron status has been associated with depression in adults and adolescents. In Swiss adolescents, we determined the associations between paediatric major depressive disorder (pMDD), inflammation, intestinal permeability and iron status.
Methods
This is a matched case–control study in 95 adolescents with diagnosed pMDD and 95 healthy controls aged 13–17 years. We assessed depression severity using the Children’s Depression Rating Scale-Revised. We measured iron status (serum ferritin (SF) and soluble transferrin receptor (sTfR)), inflammation (C-reactive protein (CRP) and alpha-1-acid-glycoprotein (AGP)), and intestinal permeability (intestinal fatty acid binding protein (I-FABP)). We assessed history of ID diagnosis and treatment with a self-reported questionnaire.
Results
SF concentrations did not differ between adolescents with pMDD (median (IQR) SF: 31.2 (20.2, 57.0) μg/L) and controls (32.5 (22.6, 48.3) μg/L,
p
= 0.4). sTfR was lower among cases than controls (4.50 (4.00, 5.50) mg/L vs 5.20 (4.75, 6.10) mg/L,
p
|
| doi_str_mv | 10.1007/s00394-023-03313-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10948461</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3153599479</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-a7881d914c412614a6a891596e78ea01172e5603bf70907da2b74c08a0906483</originalsourceid><addsrcrecordid>eNqFks1uEzEQxy0EoiXwAhyQJS69LNhrr73mglBVoFKlHujdmqydrqPNOni8rXKi79A35ElwSAgfh3LyWPOb_3wS8pKzN5wx_RYZE0ZWrBYVE4KLSj8ix1wKVamaN48PNtNH5BnikrGCKv6UHIm2Vo1u2DH5dp7iSDFDnpCGkX65DYgUXBw8dn7MSG9D7ukavAuQU-joCpYxUefXySOGG09dwJicTxRGR3sPQ-43tItjTnHAdxRKRO5672gH6L_f3e9dJenkNs_JkwUM6F_s3xm5-nh2dfq5urj8dH764aLqZGNyBbptuTNcdpLXiktQ0BreGOV164FxrmvfKCbmC80M0w7quZYda6H8lGzFjLzfya6n-cq7bWcJBrtOYQVpYyME-7dnDL29jjeWMyNbqXhRONkrpPh18pjtKpQJDQOMPk5oBW9EY4zU5r9obXjLjRJlfTPy-h90Gac0lkkUStVGSKa21dc7qksRMfnFoXDO7PYU7O4UbNmv_XkKVpegV3-2fAj5tfsCiB2AxTVe-_Q79wOyPwC18cD0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2962934068</pqid></control><display><type>article</type><title>Iron status in Swiss adolescents with paediatric major depressive disorder and healthy controls: a matched case–control study</title><source>SpringerLink Journals</source><creator>Osuna, Ester ; Baumgartner, Jeannine ; Wunderlin, Olivia ; Emery, Sophie ; Albermann, Mona ; Baumgartner, Noemi ; Schmeck, Klaus ; Walitza, Susanne ; Strumberger, Michael ; Hersberger, Martin ; Zimmermann, Michael B. ; Häberling, Isabelle ; Berger, Gregor ; Herter-Aeberli, Isabelle</creator><creatorcontrib>Osuna, Ester ; Baumgartner, Jeannine ; Wunderlin, Olivia ; Emery, Sophie ; Albermann, Mona ; Baumgartner, Noemi ; Schmeck, Klaus ; Walitza, Susanne ; Strumberger, Michael ; Hersberger, Martin ; Zimmermann, Michael B. ; Häberling, Isabelle ; Berger, Gregor ; Herter-Aeberli, Isabelle ; Omega-3 Study Team ; the Omega-3 Study Team</creatorcontrib><description>Purpose
Depression is associated with low-grade systemic inflammation and impaired intestinal function, both of which may reduce dietary iron absorption. Low iron status has been associated with depression in adults and adolescents. In Swiss adolescents, we determined the associations between paediatric major depressive disorder (pMDD), inflammation, intestinal permeability and iron status.
Methods
This is a matched case–control study in 95 adolescents with diagnosed pMDD and 95 healthy controls aged 13–17 years. We assessed depression severity using the Children’s Depression Rating Scale-Revised. We measured iron status (serum ferritin (SF) and soluble transferrin receptor (sTfR)), inflammation (C-reactive protein (CRP) and alpha-1-acid-glycoprotein (AGP)), and intestinal permeability (intestinal fatty acid binding protein (I-FABP)). We assessed history of ID diagnosis and treatment with a self-reported questionnaire.
Results
SF concentrations did not differ between adolescents with pMDD (median (IQR) SF: 31.2 (20.2, 57.0) μg/L) and controls (32.5 (22.6, 48.3) μg/L,
p
= 0.4). sTfR was lower among cases than controls (4.50 (4.00, 5.50) mg/L vs 5.20 (4.75, 6.10) mg/L,
p
< 0.001). CRP, AGP and I-FABP were higher among cases than controls (CRP: 0.16 (0.03, 0.43) mg/L vs 0.04 (0.02, 0.30) mg/L,
p
= 0.003; AGP: 0.57 (0.44, 0.70) g/L vs 0.52 (0.41, 0.67) g/L,
p
= 0.024); I-FABP: 307 (17, 515) pg/mL vs 232 (163, 357) pg/mL,
p
= 0.047). Of cases, 44% reported having a history of ID diagnosis compared to 26% among controls (
p
= 0.020). Finally, 28% of cases had iron treatment at/close to study inclusion compared to 14% among controls.
Conclusion
Cases had significantly higher systemic inflammation and intestinal permeability than controls but did not have lower iron status. Whether this is related to the higher rate of ID diagnosis and iron treatment in adolescents with depression is uncertain.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-023-03313-7</identifier><identifier>PMID: 38265750</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescents ; blood serum ; C-reactive protein ; case-control studies ; Chemistry ; Chemistry and Materials Science ; Diagnosis ; Fatty acid-binding protein ; fatty acids ; Ferritin ; Inflammation ; Intestine ; intestines ; Iron ; iron absorption ; Mental depression ; Nutrition ; Original Contribution ; Pediatrics ; Permeability ; questionnaires ; Teenagers ; transferrin receptors</subject><ispartof>European journal of nutrition, 2024-04, Vol.63 (3), p.951-963</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c459t-a7881d914c412614a6a891596e78ea01172e5603bf70907da2b74c08a0906483</cites><orcidid>0000-0002-9107-4181 ; 0000-0001-7706-6102 ; 0000-0003-3114-902X ; 0000-0003-0134-6217</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-023-03313-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-023-03313-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38265750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Osuna, Ester</creatorcontrib><creatorcontrib>Baumgartner, Jeannine</creatorcontrib><creatorcontrib>Wunderlin, Olivia</creatorcontrib><creatorcontrib>Emery, Sophie</creatorcontrib><creatorcontrib>Albermann, Mona</creatorcontrib><creatorcontrib>Baumgartner, Noemi</creatorcontrib><creatorcontrib>Schmeck, Klaus</creatorcontrib><creatorcontrib>Walitza, Susanne</creatorcontrib><creatorcontrib>Strumberger, Michael</creatorcontrib><creatorcontrib>Hersberger, Martin</creatorcontrib><creatorcontrib>Zimmermann, Michael B.</creatorcontrib><creatorcontrib>Häberling, Isabelle</creatorcontrib><creatorcontrib>Berger, Gregor</creatorcontrib><creatorcontrib>Herter-Aeberli, Isabelle</creatorcontrib><creatorcontrib>Omega-3 Study Team</creatorcontrib><creatorcontrib>the Omega-3 Study Team</creatorcontrib><title>Iron status in Swiss adolescents with paediatric major depressive disorder and healthy controls: a matched case–control study</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
Depression is associated with low-grade systemic inflammation and impaired intestinal function, both of which may reduce dietary iron absorption. Low iron status has been associated with depression in adults and adolescents. In Swiss adolescents, we determined the associations between paediatric major depressive disorder (pMDD), inflammation, intestinal permeability and iron status.
Methods
This is a matched case–control study in 95 adolescents with diagnosed pMDD and 95 healthy controls aged 13–17 years. We assessed depression severity using the Children’s Depression Rating Scale-Revised. We measured iron status (serum ferritin (SF) and soluble transferrin receptor (sTfR)), inflammation (C-reactive protein (CRP) and alpha-1-acid-glycoprotein (AGP)), and intestinal permeability (intestinal fatty acid binding protein (I-FABP)). We assessed history of ID diagnosis and treatment with a self-reported questionnaire.
Results
SF concentrations did not differ between adolescents with pMDD (median (IQR) SF: 31.2 (20.2, 57.0) μg/L) and controls (32.5 (22.6, 48.3) μg/L,
p
= 0.4). sTfR was lower among cases than controls (4.50 (4.00, 5.50) mg/L vs 5.20 (4.75, 6.10) mg/L,
p
< 0.001). CRP, AGP and I-FABP were higher among cases than controls (CRP: 0.16 (0.03, 0.43) mg/L vs 0.04 (0.02, 0.30) mg/L,
p
= 0.003; AGP: 0.57 (0.44, 0.70) g/L vs 0.52 (0.41, 0.67) g/L,
p
= 0.024); I-FABP: 307 (17, 515) pg/mL vs 232 (163, 357) pg/mL,
p
= 0.047). Of cases, 44% reported having a history of ID diagnosis compared to 26% among controls (
p
= 0.020). Finally, 28% of cases had iron treatment at/close to study inclusion compared to 14% among controls.
Conclusion
Cases had significantly higher systemic inflammation and intestinal permeability than controls but did not have lower iron status. Whether this is related to the higher rate of ID diagnosis and iron treatment in adolescents with depression is uncertain.</description><subject>Adolescents</subject><subject>blood serum</subject><subject>C-reactive protein</subject><subject>case-control studies</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Diagnosis</subject><subject>Fatty acid-binding protein</subject><subject>fatty acids</subject><subject>Ferritin</subject><subject>Inflammation</subject><subject>Intestine</subject><subject>intestines</subject><subject>Iron</subject><subject>iron absorption</subject><subject>Mental depression</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>Pediatrics</subject><subject>Permeability</subject><subject>questionnaires</subject><subject>Teenagers</subject><subject>transferrin receptors</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNqFks1uEzEQxy0EoiXwAhyQJS69LNhrr73mglBVoFKlHujdmqydrqPNOni8rXKi79A35ElwSAgfh3LyWPOb_3wS8pKzN5wx_RYZE0ZWrBYVE4KLSj8ix1wKVamaN48PNtNH5BnikrGCKv6UHIm2Vo1u2DH5dp7iSDFDnpCGkX65DYgUXBw8dn7MSG9D7ukavAuQU-joCpYxUefXySOGG09dwJicTxRGR3sPQ-43tItjTnHAdxRKRO5672gH6L_f3e9dJenkNs_JkwUM6F_s3xm5-nh2dfq5urj8dH764aLqZGNyBbptuTNcdpLXiktQ0BreGOV164FxrmvfKCbmC80M0w7quZYda6H8lGzFjLzfya6n-cq7bWcJBrtOYQVpYyME-7dnDL29jjeWMyNbqXhRONkrpPh18pjtKpQJDQOMPk5oBW9EY4zU5r9obXjLjRJlfTPy-h90Gac0lkkUStVGSKa21dc7qksRMfnFoXDO7PYU7O4UbNmv_XkKVpegV3-2fAj5tfsCiB2AxTVe-_Q79wOyPwC18cD0</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Osuna, Ester</creator><creator>Baumgartner, Jeannine</creator><creator>Wunderlin, Olivia</creator><creator>Emery, Sophie</creator><creator>Albermann, Mona</creator><creator>Baumgartner, Noemi</creator><creator>Schmeck, Klaus</creator><creator>Walitza, Susanne</creator><creator>Strumberger, Michael</creator><creator>Hersberger, Martin</creator><creator>Zimmermann, Michael B.</creator><creator>Häberling, Isabelle</creator><creator>Berger, Gregor</creator><creator>Herter-Aeberli, Isabelle</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TS</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9107-4181</orcidid><orcidid>https://orcid.org/0000-0001-7706-6102</orcidid><orcidid>https://orcid.org/0000-0003-3114-902X</orcidid><orcidid>https://orcid.org/0000-0003-0134-6217</orcidid></search><sort><creationdate>20240401</creationdate><title>Iron status in Swiss adolescents with paediatric major depressive disorder and healthy controls: a matched case–control study</title><author>Osuna, Ester ; Baumgartner, Jeannine ; Wunderlin, Olivia ; Emery, Sophie ; Albermann, Mona ; Baumgartner, Noemi ; Schmeck, Klaus ; Walitza, Susanne ; Strumberger, Michael ; Hersberger, Martin ; Zimmermann, Michael B. ; Häberling, Isabelle ; Berger, Gregor ; Herter-Aeberli, Isabelle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-a7881d914c412614a6a891596e78ea01172e5603bf70907da2b74c08a0906483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescents</topic><topic>blood serum</topic><topic>C-reactive protein</topic><topic>case-control studies</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Diagnosis</topic><topic>Fatty acid-binding protein</topic><topic>fatty acids</topic><topic>Ferritin</topic><topic>Inflammation</topic><topic>Intestine</topic><topic>intestines</topic><topic>Iron</topic><topic>iron absorption</topic><topic>Mental depression</topic><topic>Nutrition</topic><topic>Original Contribution</topic><topic>Pediatrics</topic><topic>Permeability</topic><topic>questionnaires</topic><topic>Teenagers</topic><topic>transferrin receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Osuna, Ester</creatorcontrib><creatorcontrib>Baumgartner, Jeannine</creatorcontrib><creatorcontrib>Wunderlin, Olivia</creatorcontrib><creatorcontrib>Emery, Sophie</creatorcontrib><creatorcontrib>Albermann, Mona</creatorcontrib><creatorcontrib>Baumgartner, Noemi</creatorcontrib><creatorcontrib>Schmeck, Klaus</creatorcontrib><creatorcontrib>Walitza, Susanne</creatorcontrib><creatorcontrib>Strumberger, Michael</creatorcontrib><creatorcontrib>Hersberger, Martin</creatorcontrib><creatorcontrib>Zimmermann, Michael B.</creatorcontrib><creatorcontrib>Häberling, Isabelle</creatorcontrib><creatorcontrib>Berger, Gregor</creatorcontrib><creatorcontrib>Herter-Aeberli, Isabelle</creatorcontrib><creatorcontrib>Omega-3 Study Team</creatorcontrib><creatorcontrib>the Omega-3 Study Team</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osuna, Ester</au><au>Baumgartner, Jeannine</au><au>Wunderlin, Olivia</au><au>Emery, Sophie</au><au>Albermann, Mona</au><au>Baumgartner, Noemi</au><au>Schmeck, Klaus</au><au>Walitza, Susanne</au><au>Strumberger, Michael</au><au>Hersberger, Martin</au><au>Zimmermann, Michael B.</au><au>Häberling, Isabelle</au><au>Berger, Gregor</au><au>Herter-Aeberli, Isabelle</au><aucorp>Omega-3 Study Team</aucorp><aucorp>the Omega-3 Study Team</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iron status in Swiss adolescents with paediatric major depressive disorder and healthy controls: a matched case–control study</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>63</volume><issue>3</issue><spage>951</spage><epage>963</epage><pages>951-963</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
Depression is associated with low-grade systemic inflammation and impaired intestinal function, both of which may reduce dietary iron absorption. Low iron status has been associated with depression in adults and adolescents. In Swiss adolescents, we determined the associations between paediatric major depressive disorder (pMDD), inflammation, intestinal permeability and iron status.
Methods
This is a matched case–control study in 95 adolescents with diagnosed pMDD and 95 healthy controls aged 13–17 years. We assessed depression severity using the Children’s Depression Rating Scale-Revised. We measured iron status (serum ferritin (SF) and soluble transferrin receptor (sTfR)), inflammation (C-reactive protein (CRP) and alpha-1-acid-glycoprotein (AGP)), and intestinal permeability (intestinal fatty acid binding protein (I-FABP)). We assessed history of ID diagnosis and treatment with a self-reported questionnaire.
Results
SF concentrations did not differ between adolescents with pMDD (median (IQR) SF: 31.2 (20.2, 57.0) μg/L) and controls (32.5 (22.6, 48.3) μg/L,
p
= 0.4). sTfR was lower among cases than controls (4.50 (4.00, 5.50) mg/L vs 5.20 (4.75, 6.10) mg/L,
p
< 0.001). CRP, AGP and I-FABP were higher among cases than controls (CRP: 0.16 (0.03, 0.43) mg/L vs 0.04 (0.02, 0.30) mg/L,
p
= 0.003; AGP: 0.57 (0.44, 0.70) g/L vs 0.52 (0.41, 0.67) g/L,
p
= 0.024); I-FABP: 307 (17, 515) pg/mL vs 232 (163, 357) pg/mL,
p
= 0.047). Of cases, 44% reported having a history of ID diagnosis compared to 26% among controls (
p
= 0.020). Finally, 28% of cases had iron treatment at/close to study inclusion compared to 14% among controls.
Conclusion
Cases had significantly higher systemic inflammation and intestinal permeability than controls but did not have lower iron status. Whether this is related to the higher rate of ID diagnosis and iron treatment in adolescents with depression is uncertain.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38265750</pmid><doi>10.1007/s00394-023-03313-7</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-9107-4181</orcidid><orcidid>https://orcid.org/0000-0001-7706-6102</orcidid><orcidid>https://orcid.org/0000-0003-3114-902X</orcidid><orcidid>https://orcid.org/0000-0003-0134-6217</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | European journal of nutrition, 2024-04, Vol.63 (3), p.951-963 |
| issn | 1436-6207 1436-6215 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10948461 |
| source | SpringerLink Journals |
| subjects | Adolescents blood serum C-reactive protein case-control studies Chemistry Chemistry and Materials Science Diagnosis Fatty acid-binding protein fatty acids Ferritin Inflammation Intestine intestines Iron iron absorption Mental depression Nutrition Original Contribution Pediatrics Permeability questionnaires Teenagers transferrin receptors |
| title | Iron status in Swiss adolescents with paediatric major depressive disorder and healthy controls: a matched case–control study |
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