Increased mucosal eosinophils in colonic diverticulosis and diverticular disease
Aims Eosinophils contribute to tissue homeostasis, damage, and repair. The mucosa of colonic diverticula has not been evaluated for eosinophils by quantitative histology. We aimed to investigate whether mucosal eosinophils and other immune cells are increased in colonic diverticula. Methods Hematoxy...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2023-08, Vol.38 (8), p.1355-1364 |
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| container_title | Journal of gastroenterology and hepatology |
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| creator | Cameron, Raquel Walker, Marjorie M. Jones, Michael Eslick, Guy D. Keely, Simon Pockney, Peter Cosentino, Carolina C. Talley, Nicholas J. |
| description | Aims
Eosinophils contribute to tissue homeostasis, damage, and repair. The mucosa of colonic diverticula has not been evaluated for eosinophils by quantitative histology. We aimed to investigate whether mucosal eosinophils and other immune cells are increased in colonic diverticula.
Methods
Hematoxylin and eosin stained sections from colonic surgical resections (n = 82) containing diverticula were examined. Eosinophils, neutrophils, and lymphocytes, in five high power fields in the lamina propria were counted at the base, neck, and ostia of the diverticulum and counts compared to non‐diverticula mucosa. The cohort was further subgrouped by elective and emergency surgical indications.
Results
Following an initial review of 10 surgical resections from patients with diverticulosis, a total of 82 patients with colonic resections containing diverticula from the descending colon were evaluated (median age 71.5, 42 M/40F). Eosinophil counts for the entire cohort were increased in the base and neck (median 99 and 42, both P = |
| doi_str_mv | 10.1111/jgh.16278 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10946982</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2835272720</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4048-9e02e225b376fbb7ce84e7c85eeabac822e87ab386ddf27a3271b52d4ab45ce63</originalsourceid><addsrcrecordid>eNp1kU1PGzEQhq2KqqTQA38ArcQFDhv8ufaeEEKFpEJqD_Rseb2TxJFjBzsbxL-vaVKUVqrnYHnm0aOxXoTOCB6Tcq6X88WYNFSqD2hEOMc1kbw5QiOsiKhbRtpj9DnnJcaYYyk-oWMmORGMkxH6MQ02gcnQV6vBxmx8BTG7ENcL53PlQmWjj8HZqndbSBtnB1_muTKhP2iZVB75zXOKPs6Mz_Blf5-gn_dfn-4m9eP3h-nd7WNtOeaqbgFToFR0TDazrpMWFAdplQAwnbGKUlDSdEw1fT-j0jAqSSdoz03HhYWGnaCbnXc9dCvoLYRNMl6vk1uZ9KqjcfrvSXALPY9bTXDLm1bRYrjcG1J8HiBv9MplC96bAHHImiomqCyFC3rxD7qMQwrlf4USSrREMV6oqx1lU8w5wex9G4L1W1C6BKV_B1XY88P138k_yRTgege8OA-v_zfpbw-TnfIXefmfCA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2858591834</pqid></control><display><type>article</type><title>Increased mucosal eosinophils in colonic diverticulosis and diverticular disease</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Cameron, Raquel ; Walker, Marjorie M. ; Jones, Michael ; Eslick, Guy D. ; Keely, Simon ; Pockney, Peter ; Cosentino, Carolina C. ; Talley, Nicholas J.</creator><creatorcontrib>Cameron, Raquel ; Walker, Marjorie M. ; Jones, Michael ; Eslick, Guy D. ; Keely, Simon ; Pockney, Peter ; Cosentino, Carolina C. ; Talley, Nicholas J.</creatorcontrib><description>Aims
Eosinophils contribute to tissue homeostasis, damage, and repair. The mucosa of colonic diverticula has not been evaluated for eosinophils by quantitative histology. We aimed to investigate whether mucosal eosinophils and other immune cells are increased in colonic diverticula.
Methods
Hematoxylin and eosin stained sections from colonic surgical resections (n = 82) containing diverticula were examined. Eosinophils, neutrophils, and lymphocytes, in five high power fields in the lamina propria were counted at the base, neck, and ostia of the diverticulum and counts compared to non‐diverticula mucosa. The cohort was further subgrouped by elective and emergency surgical indications.
Results
Following an initial review of 10 surgical resections from patients with diverticulosis, a total of 82 patients with colonic resections containing diverticula from the descending colon were evaluated (median age 71.5, 42 M/40F). Eosinophil counts for the entire cohort were increased in the base and neck (median 99 and 42, both P = <0.001) compared with the control location (median 16). Eosinophil counts remained significantly increased in the diverticula base (both P = <0.001) and neck (P = 0.01 and <0.001, respectively) in both elective and emergency cases. Lymphocytes were also significantly increased at the diverticula base compared to controls in both elective and emergency subgroups.
Conclusion
Eosinophils are significantly and most strikingly increased within the diverticulum in resected colonic diverticula. While these observations are novel, the role of eosinophil and chronic inflammation is as yet unclear in the pathophysiology of colonic diverticulosis and diverticular disease.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.16278</identifier><identifier>PMID: 37415341</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Anatomical histopathology ; Diverticular disease ; Diverticulitis ; Diverticulosis ; Diverticulosis, Colonic - surgery ; Diverticulum, Colon - pathology ; Diverticulum, Colon - surgery ; Eosinophil ; Eosinophilia ; Eosinophils - pathology ; Epidemiology ; Gastroenterology ; Homeostasis ; Humans ; Inflammation ; Lamina propria ; Leukocytes (eosinophilic) ; Leukocytes (neutrophilic) ; Lymphocytes ; Mucosal immunity ; Mucous Membrane ; Neck ; Original ‐ Gastroenterology (Experimental)</subject><ispartof>Journal of gastroenterology and hepatology, 2023-08, Vol.38 (8), p.1355-1364</ispartof><rights>2023 The Authors. Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4048-9e02e225b376fbb7ce84e7c85eeabac822e87ab386ddf27a3271b52d4ab45ce63</cites><orcidid>0000-0002-1248-9590 ; 0000-0003-0565-4938 ; 0000-0001-6594-3382 ; 0000-0002-0098-1705 ; 0000-0002-7788-0056 ; 0000-0002-7648-4916 ; 0000-0003-2537-3092 ; 0000-0002-2262-4995</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgh.16278$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgh.16278$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37415341$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cameron, Raquel</creatorcontrib><creatorcontrib>Walker, Marjorie M.</creatorcontrib><creatorcontrib>Jones, Michael</creatorcontrib><creatorcontrib>Eslick, Guy D.</creatorcontrib><creatorcontrib>Keely, Simon</creatorcontrib><creatorcontrib>Pockney, Peter</creatorcontrib><creatorcontrib>Cosentino, Carolina C.</creatorcontrib><creatorcontrib>Talley, Nicholas J.</creatorcontrib><title>Increased mucosal eosinophils in colonic diverticulosis and diverticular disease</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Aims
Eosinophils contribute to tissue homeostasis, damage, and repair. The mucosa of colonic diverticula has not been evaluated for eosinophils by quantitative histology. We aimed to investigate whether mucosal eosinophils and other immune cells are increased in colonic diverticula.
Methods
Hematoxylin and eosin stained sections from colonic surgical resections (n = 82) containing diverticula were examined. Eosinophils, neutrophils, and lymphocytes, in five high power fields in the lamina propria were counted at the base, neck, and ostia of the diverticulum and counts compared to non‐diverticula mucosa. The cohort was further subgrouped by elective and emergency surgical indications.
Results
Following an initial review of 10 surgical resections from patients with diverticulosis, a total of 82 patients with colonic resections containing diverticula from the descending colon were evaluated (median age 71.5, 42 M/40F). Eosinophil counts for the entire cohort were increased in the base and neck (median 99 and 42, both P = <0.001) compared with the control location (median 16). Eosinophil counts remained significantly increased in the diverticula base (both P = <0.001) and neck (P = 0.01 and <0.001, respectively) in both elective and emergency cases. Lymphocytes were also significantly increased at the diverticula base compared to controls in both elective and emergency subgroups.
Conclusion
Eosinophils are significantly and most strikingly increased within the diverticulum in resected colonic diverticula. While these observations are novel, the role of eosinophil and chronic inflammation is as yet unclear in the pathophysiology of colonic diverticulosis and diverticular disease.</description><subject>Anatomical histopathology</subject><subject>Diverticular disease</subject><subject>Diverticulitis</subject><subject>Diverticulosis</subject><subject>Diverticulosis, Colonic - surgery</subject><subject>Diverticulum, Colon - pathology</subject><subject>Diverticulum, Colon - surgery</subject><subject>Eosinophil</subject><subject>Eosinophilia</subject><subject>Eosinophils - pathology</subject><subject>Epidemiology</subject><subject>Gastroenterology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Lamina propria</subject><subject>Leukocytes (eosinophilic)</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocytes</subject><subject>Mucosal immunity</subject><subject>Mucous Membrane</subject><subject>Neck</subject><subject>Original ‐ Gastroenterology (Experimental)</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kU1PGzEQhq2KqqTQA38ArcQFDhv8ufaeEEKFpEJqD_Rseb2TxJFjBzsbxL-vaVKUVqrnYHnm0aOxXoTOCB6Tcq6X88WYNFSqD2hEOMc1kbw5QiOsiKhbRtpj9DnnJcaYYyk-oWMmORGMkxH6MQ02gcnQV6vBxmx8BTG7ENcL53PlQmWjj8HZqndbSBtnB1_muTKhP2iZVB75zXOKPs6Mz_Blf5-gn_dfn-4m9eP3h-nd7WNtOeaqbgFToFR0TDazrpMWFAdplQAwnbGKUlDSdEw1fT-j0jAqSSdoz03HhYWGnaCbnXc9dCvoLYRNMl6vk1uZ9KqjcfrvSXALPY9bTXDLm1bRYrjcG1J8HiBv9MplC96bAHHImiomqCyFC3rxD7qMQwrlf4USSrREMV6oqx1lU8w5wex9G4L1W1C6BKV_B1XY88P138k_yRTgege8OA-v_zfpbw-TnfIXefmfCA</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Cameron, Raquel</creator><creator>Walker, Marjorie M.</creator><creator>Jones, Michael</creator><creator>Eslick, Guy D.</creator><creator>Keely, Simon</creator><creator>Pockney, Peter</creator><creator>Cosentino, Carolina C.</creator><creator>Talley, Nicholas J.</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1248-9590</orcidid><orcidid>https://orcid.org/0000-0003-0565-4938</orcidid><orcidid>https://orcid.org/0000-0001-6594-3382</orcidid><orcidid>https://orcid.org/0000-0002-0098-1705</orcidid><orcidid>https://orcid.org/0000-0002-7788-0056</orcidid><orcidid>https://orcid.org/0000-0002-7648-4916</orcidid><orcidid>https://orcid.org/0000-0003-2537-3092</orcidid><orcidid>https://orcid.org/0000-0002-2262-4995</orcidid></search><sort><creationdate>202308</creationdate><title>Increased mucosal eosinophils in colonic diverticulosis and diverticular disease</title><author>Cameron, Raquel ; Walker, Marjorie M. ; Jones, Michael ; Eslick, Guy D. ; Keely, Simon ; Pockney, Peter ; Cosentino, Carolina C. ; Talley, Nicholas J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4048-9e02e225b376fbb7ce84e7c85eeabac822e87ab386ddf27a3271b52d4ab45ce63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anatomical histopathology</topic><topic>Diverticular disease</topic><topic>Diverticulitis</topic><topic>Diverticulosis</topic><topic>Diverticulosis, Colonic - surgery</topic><topic>Diverticulum, Colon - pathology</topic><topic>Diverticulum, Colon - surgery</topic><topic>Eosinophil</topic><topic>Eosinophilia</topic><topic>Eosinophils - pathology</topic><topic>Epidemiology</topic><topic>Gastroenterology</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Lamina propria</topic><topic>Leukocytes (eosinophilic)</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphocytes</topic><topic>Mucosal immunity</topic><topic>Mucous Membrane</topic><topic>Neck</topic><topic>Original ‐ Gastroenterology (Experimental)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cameron, Raquel</creatorcontrib><creatorcontrib>Walker, Marjorie M.</creatorcontrib><creatorcontrib>Jones, Michael</creatorcontrib><creatorcontrib>Eslick, Guy D.</creatorcontrib><creatorcontrib>Keely, Simon</creatorcontrib><creatorcontrib>Pockney, Peter</creatorcontrib><creatorcontrib>Cosentino, Carolina C.</creatorcontrib><creatorcontrib>Talley, Nicholas J.</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cameron, Raquel</au><au>Walker, Marjorie M.</au><au>Jones, Michael</au><au>Eslick, Guy D.</au><au>Keely, Simon</au><au>Pockney, Peter</au><au>Cosentino, Carolina C.</au><au>Talley, Nicholas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased mucosal eosinophils in colonic diverticulosis and diverticular disease</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2023-08</date><risdate>2023</risdate><volume>38</volume><issue>8</issue><spage>1355</spage><epage>1364</epage><pages>1355-1364</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Aims
Eosinophils contribute to tissue homeostasis, damage, and repair. The mucosa of colonic diverticula has not been evaluated for eosinophils by quantitative histology. We aimed to investigate whether mucosal eosinophils and other immune cells are increased in colonic diverticula.
Methods
Hematoxylin and eosin stained sections from colonic surgical resections (n = 82) containing diverticula were examined. Eosinophils, neutrophils, and lymphocytes, in five high power fields in the lamina propria were counted at the base, neck, and ostia of the diverticulum and counts compared to non‐diverticula mucosa. The cohort was further subgrouped by elective and emergency surgical indications.
Results
Following an initial review of 10 surgical resections from patients with diverticulosis, a total of 82 patients with colonic resections containing diverticula from the descending colon were evaluated (median age 71.5, 42 M/40F). Eosinophil counts for the entire cohort were increased in the base and neck (median 99 and 42, both P = <0.001) compared with the control location (median 16). Eosinophil counts remained significantly increased in the diverticula base (both P = <0.001) and neck (P = 0.01 and <0.001, respectively) in both elective and emergency cases. Lymphocytes were also significantly increased at the diverticula base compared to controls in both elective and emergency subgroups.
Conclusion
Eosinophils are significantly and most strikingly increased within the diverticulum in resected colonic diverticula. While these observations are novel, the role of eosinophil and chronic inflammation is as yet unclear in the pathophysiology of colonic diverticulosis and diverticular disease.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37415341</pmid><doi>10.1111/jgh.16278</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1248-9590</orcidid><orcidid>https://orcid.org/0000-0003-0565-4938</orcidid><orcidid>https://orcid.org/0000-0001-6594-3382</orcidid><orcidid>https://orcid.org/0000-0002-0098-1705</orcidid><orcidid>https://orcid.org/0000-0002-7788-0056</orcidid><orcidid>https://orcid.org/0000-0002-7648-4916</orcidid><orcidid>https://orcid.org/0000-0003-2537-3092</orcidid><orcidid>https://orcid.org/0000-0002-2262-4995</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of gastroenterology and hepatology, 2023-08, Vol.38 (8), p.1355-1364 |
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| subjects | Anatomical histopathology Diverticular disease Diverticulitis Diverticulosis Diverticulosis, Colonic - surgery Diverticulum, Colon - pathology Diverticulum, Colon - surgery Eosinophil Eosinophilia Eosinophils - pathology Epidemiology Gastroenterology Homeostasis Humans Inflammation Lamina propria Leukocytes (eosinophilic) Leukocytes (neutrophilic) Lymphocytes Mucosal immunity Mucous Membrane Neck Original ‐ Gastroenterology (Experimental) |
| title | Increased mucosal eosinophils in colonic diverticulosis and diverticular disease |
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