Thiophene-based lipids for mRNA delivery to pulmonary and retinal tissues

Lipid nanoparticles (LNPs) largely rely on ionizable lipids to yield successful nucleic acid delivery via electrostatic disruption of the endosomal membrane. Here, we report the identification and evaluation of ionizable lipids containing a thiophene moiety (Thio-lipids). The Thio-lipids can be read...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-03, Vol.121 (11), p.e2307813120-e2307813120
Hauptverfasser:	Eygeris, Yulia, Gupta, Mohit, Kim, Jeonghwan, Jozic, Antony, Gautam, Milan, Renner, Jonas, Nelson, Dylan, Bloom, Elissa, Tuttle, Adam, Stoddard, Jonathan, Reynaga, Rene, Neuringer, Martha, Lauer, Andreas K, Ryals, Renee C, Sahay, Gaurav
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute toxicity Animals Biocompatibility Biological Sciences Epithelium Lipid structure Lipids Localization Lung Mice Modular design mRNA Nanoparticles Nucleic acids Photoreceptors Physical Sciences Retina Retinal pigment epithelium RNA, Messenger - genetics Spleen Tissue Distribution
Online-Zugang:	Volltext
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