Atopic dermatitis, cognitive function and psychiatric comorbidities across early childhood and adolescence in a population-based UK birth cohort

Atopic dermatitis (AD) may affect cognitive function, but studies are limited and inconsistent. The effect of AD severity on cognition remains underexplored and few previous studies have examined clinically validated or repeated measures of cognition throughout childhood. To evaluate the relationshi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:British journal of dermatology (1951) 2024-03, Vol.190 (4), p.501-509
Hauptverfasser: Sockler, Patrick G, Hooper, Stephen R, Abuabara, Katrina, Ma, Emily Z, Radtke, Sarah, Bao, Aaron, Kim, Elle, Musci, Rashelle J, Kartawira, Karin, Wan, Joy
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 509
container_issue 4
container_start_page 501
container_title British journal of dermatology (1951)
container_volume 190
creator Sockler, Patrick G
Hooper, Stephen R
Abuabara, Katrina
Ma, Emily Z
Radtke, Sarah
Bao, Aaron
Kim, Elle
Musci, Rashelle J
Kartawira, Karin
Wan, Joy
description Atopic dermatitis (AD) may affect cognitive function, but studies are limited and inconsistent. The effect of AD severity on cognition remains underexplored and few previous studies have examined clinically validated or repeated measures of cognition throughout childhood. To evaluate the relationship of AD activity and severity with validated measures of general cognition in a longitudinal birth cohort. We conducted cross-sectional analyses using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK cohort of 14 975 individuals followed prospectively since their birth in 1991-92. AD was assessed 11 times between the age of 6 and 166 months. Mothers were asked if their child had an 'itchy, dry skin rash in the joints and creases', and AD status was time-updated accordingly as 'never', 'maybe', 'inactive', 'active/mild' or 'active/moderate-severe'. General cognition [i.e. intelligence quotient (IQ)] was measured at 18, 49, 103 and 186 months of age using the Griffiths Mental Development Scales (GMDS), Wechsler Preschool and Primary Scale of Intelligence (WPPSI), Wechsler Intelligence Scale for Children (WISC) and Wechsler Abbreviated Scale of Intelligence (WASI), respectively. Multivariable linear regression was used to compare IQ with respect to nearest time-updated AD status. Secondary analyses were stratified by the presence or absence of psychiatric or learning disorders. An exploratory longitudinal analysis of IQ across all four outcome assessments was conducted using generalized estimating equations. No significant associations between AD status and full-scale IQ scores on the GMDS, WPPSI, WISC and WASI were observed after adjustment for sociodemographic factors, atopic comorbidities and sleep characteristics. However, at 8 years of age, WISC Performance IQ was slightly, although statistically significantly, lower among children with active/moderate-severe AD [β coefficient -2.16, 95% confidence interval (CI) -4.12 to -0.19] and Verbal IQ was slightly, but statistically significantly, higher among those with inactive AD (β coefficient 1.31, 95% CI 0.28-2.34) compared with those without AD. Analyses stratified by psychiatric or learning disorders, and exploratory longitudinal analyses of cognition revealed similar findings. We did not find any clinically meaningful associations between AD activity and severity and general cognitive function during early childhood and adolescence. Future studies should incorporate objective measure
doi_str_mv 10.1093/bjd/ljad486
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10941325</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2902971047</sourcerecordid><originalsourceid>FETCH-LOGICAL-c345t-d9cbc01115d7c161aacbbbe61079f13251252ea14fe995346e6cefed504c20923</originalsourceid><addsrcrecordid>eNpVkUtv1DAURi0EokNhxR55iQSh13Ee4xWqKh5VK3XTri0_bhqPnDjYTqX5F_xkPO1QwcqWfHzu4yPkPYMvDAQ_0zt75nfKNtvuBdkw3rVVzTh_STYA0FcgOn5C3qS0A2AcWnhNTvgWOhD9dkN-n-ewOEMtxklll136TE24n8vtAemwzia7MFM1W7qkvRmdyrHgJkwhamcLhokqE0NKFFX0e1oYb8cQ7OMnZYPHZHA2SF3x0CUsq1cHaaVVQkvvrqh2MY_FOYaY35JXg_IJ3x3PU3L3_dvtxc_q-ubH5cX5dWV40-bKCqMNMMZa2xvWMaWM1ho7Br0YGK9bVrc1KtYMKETLmw47gwPaFhpTg6j5Kfn65F1WPaEtHeaovFyim1Tcy6Cc_P9ldqO8Dw-y7Lw5FCiGj0dDDL9WTFlOrkzqvZoxrEnWAmrRM2j6gn56Qh8XFXF4rsPgIOSyhCiPIRb6w7-tPbN_U-N_ANUcneo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2902971047</pqid></control><display><type>article</type><title>Atopic dermatitis, cognitive function and psychiatric comorbidities across early childhood and adolescence in a population-based UK birth cohort</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Sockler, Patrick G ; Hooper, Stephen R ; Abuabara, Katrina ; Ma, Emily Z ; Radtke, Sarah ; Bao, Aaron ; Kim, Elle ; Musci, Rashelle J ; Kartawira, Karin ; Wan, Joy</creator><creatorcontrib>Sockler, Patrick G ; Hooper, Stephen R ; Abuabara, Katrina ; Ma, Emily Z ; Radtke, Sarah ; Bao, Aaron ; Kim, Elle ; Musci, Rashelle J ; Kartawira, Karin ; Wan, Joy</creatorcontrib><description>Atopic dermatitis (AD) may affect cognitive function, but studies are limited and inconsistent. The effect of AD severity on cognition remains underexplored and few previous studies have examined clinically validated or repeated measures of cognition throughout childhood. To evaluate the relationship of AD activity and severity with validated measures of general cognition in a longitudinal birth cohort. We conducted cross-sectional analyses using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK cohort of 14 975 individuals followed prospectively since their birth in 1991-92. AD was assessed 11 times between the age of 6 and 166 months. Mothers were asked if their child had an 'itchy, dry skin rash in the joints and creases', and AD status was time-updated accordingly as 'never', 'maybe', 'inactive', 'active/mild' or 'active/moderate-severe'. General cognition [i.e. intelligence quotient (IQ)] was measured at 18, 49, 103 and 186 months of age using the Griffiths Mental Development Scales (GMDS), Wechsler Preschool and Primary Scale of Intelligence (WPPSI), Wechsler Intelligence Scale for Children (WISC) and Wechsler Abbreviated Scale of Intelligence (WASI), respectively. Multivariable linear regression was used to compare IQ with respect to nearest time-updated AD status. Secondary analyses were stratified by the presence or absence of psychiatric or learning disorders. An exploratory longitudinal analysis of IQ across all four outcome assessments was conducted using generalized estimating equations. No significant associations between AD status and full-scale IQ scores on the GMDS, WPPSI, WISC and WASI were observed after adjustment for sociodemographic factors, atopic comorbidities and sleep characteristics. However, at 8 years of age, WISC Performance IQ was slightly, although statistically significantly, lower among children with active/moderate-severe AD [β coefficient -2.16, 95% confidence interval (CI) -4.12 to -0.19] and Verbal IQ was slightly, but statistically significantly, higher among those with inactive AD (β coefficient 1.31, 95% CI 0.28-2.34) compared with those without AD. Analyses stratified by psychiatric or learning disorders, and exploratory longitudinal analyses of cognition revealed similar findings. We did not find any clinically meaningful associations between AD activity and severity and general cognitive function during early childhood and adolescence. Future studies should incorporate objective measures of AD severity and investigate outcomes beyond IQ.</description><identifier>ISSN: 0007-0963</identifier><identifier>ISSN: 1365-2133</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1093/bjd/ljad486</identifier><identifier>PMID: 38060978</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adolescent ; Birth Cohort ; Child ; Child, Preschool ; Cognition ; Cross-Sectional Studies ; Dermatitis, Atopic - epidemiology ; Dermatitis, Atopic - psychology ; Female ; Humans ; Learning Disabilities ; Longitudinal Studies ; Original ; United Kingdom - epidemiology</subject><ispartof>British journal of dermatology (1951), 2024-03, Vol.190 (4), p.501-509</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-d9cbc01115d7c161aacbbbe61079f13251252ea14fe995346e6cefed504c20923</citedby><cites>FETCH-LOGICAL-c345t-d9cbc01115d7c161aacbbbe61079f13251252ea14fe995346e6cefed504c20923</cites><orcidid>0000-0003-2569-9447 ; 0000-0002-0189-0442</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38060978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sockler, Patrick G</creatorcontrib><creatorcontrib>Hooper, Stephen R</creatorcontrib><creatorcontrib>Abuabara, Katrina</creatorcontrib><creatorcontrib>Ma, Emily Z</creatorcontrib><creatorcontrib>Radtke, Sarah</creatorcontrib><creatorcontrib>Bao, Aaron</creatorcontrib><creatorcontrib>Kim, Elle</creatorcontrib><creatorcontrib>Musci, Rashelle J</creatorcontrib><creatorcontrib>Kartawira, Karin</creatorcontrib><creatorcontrib>Wan, Joy</creatorcontrib><title>Atopic dermatitis, cognitive function and psychiatric comorbidities across early childhood and adolescence in a population-based UK birth cohort</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Atopic dermatitis (AD) may affect cognitive function, but studies are limited and inconsistent. The effect of AD severity on cognition remains underexplored and few previous studies have examined clinically validated or repeated measures of cognition throughout childhood. To evaluate the relationship of AD activity and severity with validated measures of general cognition in a longitudinal birth cohort. We conducted cross-sectional analyses using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK cohort of 14 975 individuals followed prospectively since their birth in 1991-92. AD was assessed 11 times between the age of 6 and 166 months. Mothers were asked if their child had an 'itchy, dry skin rash in the joints and creases', and AD status was time-updated accordingly as 'never', 'maybe', 'inactive', 'active/mild' or 'active/moderate-severe'. General cognition [i.e. intelligence quotient (IQ)] was measured at 18, 49, 103 and 186 months of age using the Griffiths Mental Development Scales (GMDS), Wechsler Preschool and Primary Scale of Intelligence (WPPSI), Wechsler Intelligence Scale for Children (WISC) and Wechsler Abbreviated Scale of Intelligence (WASI), respectively. Multivariable linear regression was used to compare IQ with respect to nearest time-updated AD status. Secondary analyses were stratified by the presence or absence of psychiatric or learning disorders. An exploratory longitudinal analysis of IQ across all four outcome assessments was conducted using generalized estimating equations. No significant associations between AD status and full-scale IQ scores on the GMDS, WPPSI, WISC and WASI were observed after adjustment for sociodemographic factors, atopic comorbidities and sleep characteristics. However, at 8 years of age, WISC Performance IQ was slightly, although statistically significantly, lower among children with active/moderate-severe AD [β coefficient -2.16, 95% confidence interval (CI) -4.12 to -0.19] and Verbal IQ was slightly, but statistically significantly, higher among those with inactive AD (β coefficient 1.31, 95% CI 0.28-2.34) compared with those without AD. Analyses stratified by psychiatric or learning disorders, and exploratory longitudinal analyses of cognition revealed similar findings. We did not find any clinically meaningful associations between AD activity and severity and general cognitive function during early childhood and adolescence. Future studies should incorporate objective measures of AD severity and investigate outcomes beyond IQ.</description><subject>Adolescent</subject><subject>Birth Cohort</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cognition</subject><subject>Cross-Sectional Studies</subject><subject>Dermatitis, Atopic - epidemiology</subject><subject>Dermatitis, Atopic - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Learning Disabilities</subject><subject>Longitudinal Studies</subject><subject>Original</subject><subject>United Kingdom - epidemiology</subject><issn>0007-0963</issn><issn>1365-2133</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtv1DAURi0EokNhxR55iQSh13Ee4xWqKh5VK3XTri0_bhqPnDjYTqX5F_xkPO1QwcqWfHzu4yPkPYMvDAQ_0zt75nfKNtvuBdkw3rVVzTh_STYA0FcgOn5C3qS0A2AcWnhNTvgWOhD9dkN-n-ewOEMtxklll136TE24n8vtAemwzia7MFM1W7qkvRmdyrHgJkwhamcLhokqE0NKFFX0e1oYb8cQ7OMnZYPHZHA2SF3x0CUsq1cHaaVVQkvvrqh2MY_FOYaY35JXg_IJ3x3PU3L3_dvtxc_q-ubH5cX5dWV40-bKCqMNMMZa2xvWMaWM1ho7Br0YGK9bVrc1KtYMKETLmw47gwPaFhpTg6j5Kfn65F1WPaEtHeaovFyim1Tcy6Cc_P9ldqO8Dw-y7Lw5FCiGj0dDDL9WTFlOrkzqvZoxrEnWAmrRM2j6gn56Qh8XFXF4rsPgIOSyhCiPIRb6w7-tPbN_U-N_ANUcneo</recordid><startdate>20240315</startdate><enddate>20240315</enddate><creator>Sockler, Patrick G</creator><creator>Hooper, Stephen R</creator><creator>Abuabara, Katrina</creator><creator>Ma, Emily Z</creator><creator>Radtke, Sarah</creator><creator>Bao, Aaron</creator><creator>Kim, Elle</creator><creator>Musci, Rashelle J</creator><creator>Kartawira, Karin</creator><creator>Wan, Joy</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2569-9447</orcidid><orcidid>https://orcid.org/0000-0002-0189-0442</orcidid></search><sort><creationdate>20240315</creationdate><title>Atopic dermatitis, cognitive function and psychiatric comorbidities across early childhood and adolescence in a population-based UK birth cohort</title><author>Sockler, Patrick G ; Hooper, Stephen R ; Abuabara, Katrina ; Ma, Emily Z ; Radtke, Sarah ; Bao, Aaron ; Kim, Elle ; Musci, Rashelle J ; Kartawira, Karin ; Wan, Joy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-d9cbc01115d7c161aacbbbe61079f13251252ea14fe995346e6cefed504c20923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Birth Cohort</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cognition</topic><topic>Cross-Sectional Studies</topic><topic>Dermatitis, Atopic - epidemiology</topic><topic>Dermatitis, Atopic - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Learning Disabilities</topic><topic>Longitudinal Studies</topic><topic>Original</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sockler, Patrick G</creatorcontrib><creatorcontrib>Hooper, Stephen R</creatorcontrib><creatorcontrib>Abuabara, Katrina</creatorcontrib><creatorcontrib>Ma, Emily Z</creatorcontrib><creatorcontrib>Radtke, Sarah</creatorcontrib><creatorcontrib>Bao, Aaron</creatorcontrib><creatorcontrib>Kim, Elle</creatorcontrib><creatorcontrib>Musci, Rashelle J</creatorcontrib><creatorcontrib>Kartawira, Karin</creatorcontrib><creatorcontrib>Wan, Joy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sockler, Patrick G</au><au>Hooper, Stephen R</au><au>Abuabara, Katrina</au><au>Ma, Emily Z</au><au>Radtke, Sarah</au><au>Bao, Aaron</au><au>Kim, Elle</au><au>Musci, Rashelle J</au><au>Kartawira, Karin</au><au>Wan, Joy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atopic dermatitis, cognitive function and psychiatric comorbidities across early childhood and adolescence in a population-based UK birth cohort</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2024-03-15</date><risdate>2024</risdate><volume>190</volume><issue>4</issue><spage>501</spage><epage>509</epage><pages>501-509</pages><issn>0007-0963</issn><issn>1365-2133</issn><eissn>1365-2133</eissn><abstract>Atopic dermatitis (AD) may affect cognitive function, but studies are limited and inconsistent. The effect of AD severity on cognition remains underexplored and few previous studies have examined clinically validated or repeated measures of cognition throughout childhood. To evaluate the relationship of AD activity and severity with validated measures of general cognition in a longitudinal birth cohort. We conducted cross-sectional analyses using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK cohort of 14 975 individuals followed prospectively since their birth in 1991-92. AD was assessed 11 times between the age of 6 and 166 months. Mothers were asked if their child had an 'itchy, dry skin rash in the joints and creases', and AD status was time-updated accordingly as 'never', 'maybe', 'inactive', 'active/mild' or 'active/moderate-severe'. General cognition [i.e. intelligence quotient (IQ)] was measured at 18, 49, 103 and 186 months of age using the Griffiths Mental Development Scales (GMDS), Wechsler Preschool and Primary Scale of Intelligence (WPPSI), Wechsler Intelligence Scale for Children (WISC) and Wechsler Abbreviated Scale of Intelligence (WASI), respectively. Multivariable linear regression was used to compare IQ with respect to nearest time-updated AD status. Secondary analyses were stratified by the presence or absence of psychiatric or learning disorders. An exploratory longitudinal analysis of IQ across all four outcome assessments was conducted using generalized estimating equations. No significant associations between AD status and full-scale IQ scores on the GMDS, WPPSI, WISC and WASI were observed after adjustment for sociodemographic factors, atopic comorbidities and sleep characteristics. However, at 8 years of age, WISC Performance IQ was slightly, although statistically significantly, lower among children with active/moderate-severe AD [β coefficient -2.16, 95% confidence interval (CI) -4.12 to -0.19] and Verbal IQ was slightly, but statistically significantly, higher among those with inactive AD (β coefficient 1.31, 95% CI 0.28-2.34) compared with those without AD. Analyses stratified by psychiatric or learning disorders, and exploratory longitudinal analyses of cognition revealed similar findings. We did not find any clinically meaningful associations between AD activity and severity and general cognitive function during early childhood and adolescence. Future studies should incorporate objective measures of AD severity and investigate outcomes beyond IQ.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>38060978</pmid><doi>10.1093/bjd/ljad486</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2569-9447</orcidid><orcidid>https://orcid.org/0000-0002-0189-0442</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0007-0963
ispartof British journal of dermatology (1951), 2024-03, Vol.190 (4), p.501-509
issn 0007-0963
1365-2133
1365-2133
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10941325
source MEDLINE; Oxford University Press Journals All Titles (1996-Current)
subjects Adolescent
Birth Cohort
Child
Child, Preschool
Cognition
Cross-Sectional Studies
Dermatitis, Atopic - epidemiology
Dermatitis, Atopic - psychology
Female
Humans
Learning Disabilities
Longitudinal Studies
Original
United Kingdom - epidemiology
title Atopic dermatitis, cognitive function and psychiatric comorbidities across early childhood and adolescence in a population-based UK birth cohort
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T12%3A23%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Atopic%20dermatitis,%20cognitive%20function%20and%20psychiatric%20comorbidities%20across%20early%20childhood%20and%20adolescence%20in%20a%20population-based%20UK%20birth%20cohort&rft.jtitle=British%20journal%20of%20dermatology%20(1951)&rft.au=Sockler,%20Patrick%20G&rft.date=2024-03-15&rft.volume=190&rft.issue=4&rft.spage=501&rft.epage=509&rft.pages=501-509&rft.issn=0007-0963&rft.eissn=1365-2133&rft_id=info:doi/10.1093/bjd/ljad486&rft_dat=%3Cproquest_pubme%3E2902971047%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2902971047&rft_id=info:pmid/38060978&rfr_iscdi=true