Skin photoageing following sun exposure is associated with decreased epigenetic and biologic age, and correlates with basal cell carcinoma phenotype
This study investigated epigenetic changes, specifically epigenetic ageing, in an adult cohort of healthy individuals using five validated epigenetic clock algorithms and a DNA methylation-based estimator of telomere length. Our study demonstrated significant biologic/epigenetic age dysregulation in...
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| Veröffentlicht in: | British journal of dermatology (1951) 2024-03, Vol.190 (4), p.590-592 |
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| container_title | British journal of dermatology (1951) |
| container_volume | 190 |
| creator | Jeremian, Richie Malinowski, Alexandra Lytvyn, Yuliya Georgakopoulos, Jorge R Muntyanu, Anastasiya Mufti, Asfandyar Lefrançois, Philippe Yeung, Jensen Litvinov, Ivan V |
| description | This study investigated epigenetic changes, specifically epigenetic ageing, in an adult cohort of healthy individuals using five validated epigenetic clock algorithms and a DNA methylation-based estimator of telomere length. Our study demonstrated significant biologic/epigenetic age dysregulation in sun-exposed vs. sun-protected dermal and epidermal skin, with a strong correlation to the validated Helfrich skin photoageing scale, occurring in patterns that overlap with those seen in basal cell carcinoma. This work highlights the power of novel epigenetic analyses in studying photoageing and skin cancer predisposition. |
| doi_str_mv | 10.1093/bjd/ljad527 |
| format | Article |
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Our study demonstrated significant biologic/epigenetic age dysregulation in sun-exposed vs. sun-protected dermal and epidermal skin, with a strong correlation to the validated Helfrich skin photoageing scale, occurring in patterns that overlap with those seen in basal cell carcinoma. This work highlights the power of novel epigenetic analyses in studying photoageing and skin cancer predisposition.</description><identifier>ISSN: 0007-0963</identifier><identifier>ISSN: 1365-2133</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1093/bjd/ljad527</identifier><identifier>PMID: 38133632</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Biological Products ; Carcinoma, Basal Cell - genetics ; Epigenesis, Genetic ; Humans ; Phenotype ; Research Letter ; Skin ; Skin Aging - genetics ; Skin Neoplasms - genetics ; Sunlight - adverse effects</subject><ispartof>British journal of dermatology (1951), 2024-03, Vol.190 (4), p.590-592</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. 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This work highlights the power of novel epigenetic analyses in studying photoageing and skin cancer predisposition.</description><subject>Biological Products</subject><subject>Carcinoma, Basal Cell - genetics</subject><subject>Epigenesis, Genetic</subject><subject>Humans</subject><subject>Phenotype</subject><subject>Research Letter</subject><subject>Skin</subject><subject>Skin Aging - genetics</subject><subject>Skin Neoplasms - genetics</subject><subject>Sunlight - adverse effects</subject><issn>0007-0963</issn><issn>1365-2133</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU2PFCEQholx446rJ--Go4n2LlD9NSdjNn4lm3hQz4SGooeRgRa6XfeHePe3-MuWcWY3egGqeOqtgpeQZ5ydc7aGi2FrLvxWmUZ0D8iKQ9tUggM8JCvGWFexdQun5HHOW8Y4sIY9IqfQF6AFsSK_Pn9zgU6bOEc1ogsjtdH7eL0_5SVQ_DnFvCSkLv_5rXKO2qkZDb1284Ya1AlVLiFObsSAs9NUBUMHF30c98GIr_5mdEwJfSnNh9JBZeWpRl8WlbQLcafKGBjifDPhE3Jilc_49Lifka_v3n65_FBdfXr_8fLNVaWBwVxZFND3QnXQa1MLGGrsTGewhppBxzW3g0XQ7SAsb_qOc9vWujVcNzWyzg5wRl4fdKdl2KHRGOakvJyS26l0I6Ny8v-b4DZyjD9k-fiag4Ci8OKokOL3BfMsdy7vn6UCxiVLsWZNI3jd9wV9eUB1ijkntPd9ONsLgixOyqOThX7-72j37J11cAuF66Cg</recordid><startdate>20240315</startdate><enddate>20240315</enddate><creator>Jeremian, Richie</creator><creator>Malinowski, Alexandra</creator><creator>Lytvyn, Yuliya</creator><creator>Georgakopoulos, Jorge R</creator><creator>Muntyanu, Anastasiya</creator><creator>Mufti, Asfandyar</creator><creator>Lefrançois, Philippe</creator><creator>Yeung, Jensen</creator><creator>Litvinov, Ivan V</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1805-9994</orcidid><orcidid>https://orcid.org/0000-0002-3514-9513</orcidid><orcidid>https://orcid.org/0000-0002-9776-866X</orcidid><orcidid>https://orcid.org/0000-0001-9258-6296</orcidid><orcidid>https://orcid.org/0000-0003-0562-4675</orcidid></search><sort><creationdate>20240315</creationdate><title>Skin photoageing following sun exposure is associated with decreased epigenetic and biologic age, and correlates with basal cell carcinoma phenotype</title><author>Jeremian, Richie ; 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Our study demonstrated significant biologic/epigenetic age dysregulation in sun-exposed vs. sun-protected dermal and epidermal skin, with a strong correlation to the validated Helfrich skin photoageing scale, occurring in patterns that overlap with those seen in basal cell carcinoma. This work highlights the power of novel epigenetic analyses in studying photoageing and skin cancer predisposition.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>38133632</pmid><doi>10.1093/bjd/ljad527</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0003-1805-9994</orcidid><orcidid>https://orcid.org/0000-0002-3514-9513</orcidid><orcidid>https://orcid.org/0000-0002-9776-866X</orcidid><orcidid>https://orcid.org/0000-0001-9258-6296</orcidid><orcidid>https://orcid.org/0000-0003-0562-4675</orcidid></addata></record> |
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| identifier | ISSN: 0007-0963 |
| ispartof | British journal of dermatology (1951), 2024-03, Vol.190 (4), p.590-592 |
| issn | 0007-0963 1365-2133 1365-2133 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10941323 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Biological Products Carcinoma, Basal Cell - genetics Epigenesis, Genetic Humans Phenotype Research Letter Skin Skin Aging - genetics Skin Neoplasms - genetics Sunlight - adverse effects |
| title | Skin photoageing following sun exposure is associated with decreased epigenetic and biologic age, and correlates with basal cell carcinoma phenotype |
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