Membrane-proximal motifs are the primary determinants of signaling strength differences between type I and III interferon receptors

Interferons (IFNs) play crucial roles in antiviral defenses. Despite using the same Janus-activated kinase (JAK)–signal transducer and activator of transcription (STAT) signaling cascade, type I and III IFN receptors differ in the magnitude and dynamics of their signaling in terms of STAT phosphoryl...

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Veröffentlicht in:	Science signaling 2023-10, Vol.16 (806), p.eadf5494-eadf5494
Hauptverfasser:	Mesev, Emily V., Lin, Aaron E., Guare, Emma G., Heller, Brigitte L., Douam, Florian, Adamson, Britt, Toettcher, Jared E., Ploss, Alexander
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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