Effectiveness, safety, and patient satisfaction of carboxytherapy as an adjunctive treatment for periorbital hyperpigmentation

Introduction Dark under‐eye circles or periorbital hyperpigmentation constitute a prevalent and challenging cosmetic problem with diverse etiologies and types. While modifying exacerbating habits can provide partial relief for the pigmentary and vascular factors associated with this condition, and d...

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Veröffentlicht in:Skin research and technology 2024-03, Vol.30 (3), p.e13651-n/a
Hauptverfasser: Seirafianpour, Farnoosh, Atefi, Najmolsadat, Amin, Nazila Ghoreishi, Namazi, Mohammad Reza, Behrangi, Elham, Shafiei, Aboozar, Ghassemi, Mohammadreza, Mozafarpoor, Samaneh, Goodarzi, Azadeh
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container_issue 3
container_start_page e13651
container_title Skin research and technology
container_volume 30
creator Seirafianpour, Farnoosh
Atefi, Najmolsadat
Amin, Nazila Ghoreishi
Namazi, Mohammad Reza
Behrangi, Elham
Shafiei, Aboozar
Ghassemi, Mohammadreza
Mozafarpoor, Samaneh
Goodarzi, Azadeh
description Introduction Dark under‐eye circles or periorbital hyperpigmentation constitute a prevalent and challenging cosmetic problem with diverse etiologies and types. While modifying exacerbating habits can provide partial relief for the pigmentary and vascular factors associated with this condition, and despite the abundance of available treatment options, there is currently a lack of gold‐standard evidence‐based treatments proposed for curing this disorder. Objectives This study aimed to assess the safety and effectiveness of carboxytherapy in treating periorbital hyperpigmentation. Material and Methods In this 4‐week single‐arm clinical trial, 20 eligible Iranian patients with symmetric periorbital hyperpigmentation received weekly intradermal carboxytherapy. The treatment involved administering 10–20 mL of CO2 at a rate of 20 mL/min and a temperature of 15°C for a duration ranging from a few seconds to 1 min. Follow‐up assessments were conducted 1 month after the final session. The primary outcome was defined as the changes in ΔE or the variations in pigmentation observed between the orbital and extra‐orbital skin before and after the trial. Results The patients reported satisfaction with the statistically significant reduction in hyperpigmentation achieved through carboxytherapy in the lateral (p = 0.002), middle (p = 0.001), and medial (p = 0.001) regions of the periorbital area. The total response rate of the patients was estimated at 20%. Patient satisfaction exceeded ΔE changes, with no significant linear relationship (p = 0.084). Conclusion Carboxytherapy can be proposed as an effective and safe treatment for periorbital hyperpigmentation.
doi_str_mv 10.1111/srt.13651
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While modifying exacerbating habits can provide partial relief for the pigmentary and vascular factors associated with this condition, and despite the abundance of available treatment options, there is currently a lack of gold‐standard evidence‐based treatments proposed for curing this disorder. Objectives This study aimed to assess the safety and effectiveness of carboxytherapy in treating periorbital hyperpigmentation. Material and Methods In this 4‐week single‐arm clinical trial, 20 eligible Iranian patients with symmetric periorbital hyperpigmentation received weekly intradermal carboxytherapy. The treatment involved administering 10–20 mL of CO2 at a rate of 20 mL/min and a temperature of 15°C for a duration ranging from a few seconds to 1 min. Follow‐up assessments were conducted 1 month after the final session. The primary outcome was defined as the changes in ΔE or the variations in pigmentation observed between the orbital and extra‐orbital skin before and after the trial. Results The patients reported satisfaction with the statistically significant reduction in hyperpigmentation achieved through carboxytherapy in the lateral (p = 0.002), middle (p = 0.001), and medial (p = 0.001) regions of the periorbital area. The total response rate of the patients was estimated at 20%. Patient satisfaction exceeded ΔE changes, with no significant linear relationship (p = 0.084). Conclusion Carboxytherapy can be proposed as an effective and safe treatment for periorbital hyperpigmentation.</description><identifier>ISSN: 0909-752X</identifier><identifier>ISSN: 1600-0846</identifier><identifier>EISSN: 1600-0846</identifier><identifier>DOI: 10.1111/srt.13651</identifier><identifier>PMID: 38483051</identifier><language>eng</language><publisher>England: John Wiley &amp; Sons, Inc</publisher><subject>Carbon dioxide ; carboxytherapy ; CO2 therapy ; dark eye circles ; DECs ; Effectiveness ; eye dark circles ; Humans ; Hyperpigmentation ; Hyperpigmentation - etiology ; Hyperpigmentation - radiotherapy ; infraorbital darkening ; Iran ; Original ; Patient Satisfaction ; Patients ; periorbital darkening ; periorbital hyperpigmentation ; Pigmentation ; Safety ; Skin ; Statistical analysis ; trail ; Treatment Outcome</subject><ispartof>Skin research and technology, 2024-03, Vol.30 (3), p.e13651-n/a</ispartof><rights>2024 The Authors. published by John Wiley &amp; Sons Ltd.</rights><rights>2024 The Authors. 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While modifying exacerbating habits can provide partial relief for the pigmentary and vascular factors associated with this condition, and despite the abundance of available treatment options, there is currently a lack of gold‐standard evidence‐based treatments proposed for curing this disorder. Objectives This study aimed to assess the safety and effectiveness of carboxytherapy in treating periorbital hyperpigmentation. Material and Methods In this 4‐week single‐arm clinical trial, 20 eligible Iranian patients with symmetric periorbital hyperpigmentation received weekly intradermal carboxytherapy. The treatment involved administering 10–20 mL of CO2 at a rate of 20 mL/min and a temperature of 15°C for a duration ranging from a few seconds to 1 min. Follow‐up assessments were conducted 1 month after the final session. The primary outcome was defined as the changes in ΔE or the variations in pigmentation observed between the orbital and extra‐orbital skin before and after the trial. Results The patients reported satisfaction with the statistically significant reduction in hyperpigmentation achieved through carboxytherapy in the lateral (p = 0.002), middle (p = 0.001), and medial (p = 0.001) regions of the periorbital area. The total response rate of the patients was estimated at 20%. Patient satisfaction exceeded ΔE changes, with no significant linear relationship (p = 0.084). 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While modifying exacerbating habits can provide partial relief for the pigmentary and vascular factors associated with this condition, and despite the abundance of available treatment options, there is currently a lack of gold‐standard evidence‐based treatments proposed for curing this disorder. Objectives This study aimed to assess the safety and effectiveness of carboxytherapy in treating periorbital hyperpigmentation. Material and Methods In this 4‐week single‐arm clinical trial, 20 eligible Iranian patients with symmetric periorbital hyperpigmentation received weekly intradermal carboxytherapy. The treatment involved administering 10–20 mL of CO2 at a rate of 20 mL/min and a temperature of 15°C for a duration ranging from a few seconds to 1 min. Follow‐up assessments were conducted 1 month after the final session. The primary outcome was defined as the changes in ΔE or the variations in pigmentation observed between the orbital and extra‐orbital skin before and after the trial. Results The patients reported satisfaction with the statistically significant reduction in hyperpigmentation achieved through carboxytherapy in the lateral (p = 0.002), middle (p = 0.001), and medial (p = 0.001) regions of the periorbital area. The total response rate of the patients was estimated at 20%. Patient satisfaction exceeded ΔE changes, with no significant linear relationship (p = 0.084). Conclusion Carboxytherapy can be proposed as an effective and safe treatment for periorbital hyperpigmentation.</abstract><cop>England</cop><pub>John Wiley &amp; Sons, Inc</pub><pmid>38483051</pmid><doi>10.1111/srt.13651</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3794-6206</orcidid><orcidid>https://orcid.org/0000-0002-1249-4429</orcidid><oa>free_for_read</oa></addata></record>
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source MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central
subjects Carbon dioxide
carboxytherapy
CO2 therapy
dark eye circles
DECs
Effectiveness
eye dark circles
Humans
Hyperpigmentation
Hyperpigmentation - etiology
Hyperpigmentation - radiotherapy
infraorbital darkening
Iran
Original
Patient Satisfaction
Patients
periorbital darkening
periorbital hyperpigmentation
Pigmentation
Safety
Skin
Statistical analysis
trail
Treatment Outcome
title Effectiveness, safety, and patient satisfaction of carboxytherapy as an adjunctive treatment for periorbital hyperpigmentation
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