Effectiveness, safety, and patient satisfaction of carboxytherapy as an adjunctive treatment for periorbital hyperpigmentation
Introduction Dark under‐eye circles or periorbital hyperpigmentation constitute a prevalent and challenging cosmetic problem with diverse etiologies and types. While modifying exacerbating habits can provide partial relief for the pigmentary and vascular factors associated with this condition, and d...
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creator | Seirafianpour, Farnoosh Atefi, Najmolsadat Amin, Nazila Ghoreishi Namazi, Mohammad Reza Behrangi, Elham Shafiei, Aboozar Ghassemi, Mohammadreza Mozafarpoor, Samaneh Goodarzi, Azadeh |
description | Introduction
Dark under‐eye circles or periorbital hyperpigmentation constitute a prevalent and challenging cosmetic problem with diverse etiologies and types. While modifying exacerbating habits can provide partial relief for the pigmentary and vascular factors associated with this condition, and despite the abundance of available treatment options, there is currently a lack of gold‐standard evidence‐based treatments proposed for curing this disorder.
Objectives
This study aimed to assess the safety and effectiveness of carboxytherapy in treating periorbital hyperpigmentation.
Material and Methods
In this 4‐week single‐arm clinical trial, 20 eligible Iranian patients with symmetric periorbital hyperpigmentation received weekly intradermal carboxytherapy. The treatment involved administering 10–20 mL of CO2 at a rate of 20 mL/min and a temperature of 15°C for a duration ranging from a few seconds to 1 min. Follow‐up assessments were conducted 1 month after the final session. The primary outcome was defined as the changes in ΔE or the variations in pigmentation observed between the orbital and extra‐orbital skin before and after the trial.
Results
The patients reported satisfaction with the statistically significant reduction in hyperpigmentation achieved through carboxytherapy in the lateral (p = 0.002), middle (p = 0.001), and medial (p = 0.001) regions of the periorbital area. The total response rate of the patients was estimated at 20%. Patient satisfaction exceeded ΔE changes, with no significant linear relationship (p = 0.084).
Conclusion
Carboxytherapy can be proposed as an effective and safe treatment for periorbital hyperpigmentation. |
doi_str_mv | 10.1111/srt.13651 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10938787</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2957167633</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4981-a16ad4c0abd8be09c969a99b1d306add6c358d96fc7eaab5e88479732aa987dd3</originalsourceid><addsrcrecordid>eNp1kU1rFTEUhoMo9ra68A9IwI2FTpvczORjVaTUDygIWsFdOJNkenOZOxmTTHU2_nYzvbWoYDYhOU-ec8KL0AtKTmlZZynmU8p4Qx-hFeWEVETW_DFaEUVUJZr11wN0mNKWENIoyp6iAyZryUhDV-jnZdc5k_2tG1xKJzhB5_J8gmGweITs3ZDLXfapg0KFAYcOG4ht-DHnjYswzhhSoTHY7TTciXCODvJuedmFiEcXfYitz9DjzVxOo79ZirDonqEnHfTJPb_fj9CXt5fXF--rq4_vPly8uapMrSStgHKwtSHQWtk6ooziCpRqqWWkVCw3rJFW8c4IB9A2TspaKMHWAEoKa9kROt97x6ndOWtK_wi9HqPfQZx1AK__rgx-o2_CraZEMSmkKIbX94YYvk0uZb3zybi-h8GFKem1agTlgjNW0Ff_oNswxaH8r1BSUMHXzSI83lMmhpSi6x6moUQvseoSq76LtbAv_xz_gfydYwHO9sB337v5_yb9-dP1XvkLq-Oxbw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2987176257</pqid></control><display><type>article</type><title>Effectiveness, safety, and patient satisfaction of carboxytherapy as an adjunctive treatment for periorbital hyperpigmentation</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><creator>Seirafianpour, Farnoosh ; Atefi, Najmolsadat ; Amin, Nazila Ghoreishi ; Namazi, Mohammad Reza ; Behrangi, Elham ; Shafiei, Aboozar ; Ghassemi, Mohammadreza ; Mozafarpoor, Samaneh ; Goodarzi, Azadeh</creator><creatorcontrib>Seirafianpour, Farnoosh ; Atefi, Najmolsadat ; Amin, Nazila Ghoreishi ; Namazi, Mohammad Reza ; Behrangi, Elham ; Shafiei, Aboozar ; Ghassemi, Mohammadreza ; Mozafarpoor, Samaneh ; Goodarzi, Azadeh</creatorcontrib><description>Introduction
Dark under‐eye circles or periorbital hyperpigmentation constitute a prevalent and challenging cosmetic problem with diverse etiologies and types. While modifying exacerbating habits can provide partial relief for the pigmentary and vascular factors associated with this condition, and despite the abundance of available treatment options, there is currently a lack of gold‐standard evidence‐based treatments proposed for curing this disorder.
Objectives
This study aimed to assess the safety and effectiveness of carboxytherapy in treating periorbital hyperpigmentation.
Material and Methods
In this 4‐week single‐arm clinical trial, 20 eligible Iranian patients with symmetric periorbital hyperpigmentation received weekly intradermal carboxytherapy. The treatment involved administering 10–20 mL of CO2 at a rate of 20 mL/min and a temperature of 15°C for a duration ranging from a few seconds to 1 min. Follow‐up assessments were conducted 1 month after the final session. The primary outcome was defined as the changes in ΔE or the variations in pigmentation observed between the orbital and extra‐orbital skin before and after the trial.
Results
The patients reported satisfaction with the statistically significant reduction in hyperpigmentation achieved through carboxytherapy in the lateral (p = 0.002), middle (p = 0.001), and medial (p = 0.001) regions of the periorbital area. The total response rate of the patients was estimated at 20%. Patient satisfaction exceeded ΔE changes, with no significant linear relationship (p = 0.084).
Conclusion
Carboxytherapy can be proposed as an effective and safe treatment for periorbital hyperpigmentation.</description><identifier>ISSN: 0909-752X</identifier><identifier>ISSN: 1600-0846</identifier><identifier>EISSN: 1600-0846</identifier><identifier>DOI: 10.1111/srt.13651</identifier><identifier>PMID: 38483051</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Carbon dioxide ; carboxytherapy ; CO2 therapy ; dark eye circles ; DECs ; Effectiveness ; eye dark circles ; Humans ; Hyperpigmentation ; Hyperpigmentation - etiology ; Hyperpigmentation - radiotherapy ; infraorbital darkening ; Iran ; Original ; Patient Satisfaction ; Patients ; periorbital darkening ; periorbital hyperpigmentation ; Pigmentation ; Safety ; Skin ; Statistical analysis ; trail ; Treatment Outcome</subject><ispartof>Skin research and technology, 2024-03, Vol.30 (3), p.e13651-n/a</ispartof><rights>2024 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2024 The Authors. Skin Research and Technology published by John Wiley & Sons Ltd.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4981-a16ad4c0abd8be09c969a99b1d306add6c358d96fc7eaab5e88479732aa987dd3</citedby><cites>FETCH-LOGICAL-c4981-a16ad4c0abd8be09c969a99b1d306add6c358d96fc7eaab5e88479732aa987dd3</cites><orcidid>0000-0003-3794-6206 ; 0000-0002-1249-4429</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10938787/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10938787/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,1419,11569,27931,27932,45581,45582,46059,46483,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38483051$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seirafianpour, Farnoosh</creatorcontrib><creatorcontrib>Atefi, Najmolsadat</creatorcontrib><creatorcontrib>Amin, Nazila Ghoreishi</creatorcontrib><creatorcontrib>Namazi, Mohammad Reza</creatorcontrib><creatorcontrib>Behrangi, Elham</creatorcontrib><creatorcontrib>Shafiei, Aboozar</creatorcontrib><creatorcontrib>Ghassemi, Mohammadreza</creatorcontrib><creatorcontrib>Mozafarpoor, Samaneh</creatorcontrib><creatorcontrib>Goodarzi, Azadeh</creatorcontrib><title>Effectiveness, safety, and patient satisfaction of carboxytherapy as an adjunctive treatment for periorbital hyperpigmentation</title><title>Skin research and technology</title><addtitle>Skin Res Technol</addtitle><description>Introduction
Dark under‐eye circles or periorbital hyperpigmentation constitute a prevalent and challenging cosmetic problem with diverse etiologies and types. While modifying exacerbating habits can provide partial relief for the pigmentary and vascular factors associated with this condition, and despite the abundance of available treatment options, there is currently a lack of gold‐standard evidence‐based treatments proposed for curing this disorder.
Objectives
This study aimed to assess the safety and effectiveness of carboxytherapy in treating periorbital hyperpigmentation.
Material and Methods
In this 4‐week single‐arm clinical trial, 20 eligible Iranian patients with symmetric periorbital hyperpigmentation received weekly intradermal carboxytherapy. The treatment involved administering 10–20 mL of CO2 at a rate of 20 mL/min and a temperature of 15°C for a duration ranging from a few seconds to 1 min. Follow‐up assessments were conducted 1 month after the final session. The primary outcome was defined as the changes in ΔE or the variations in pigmentation observed between the orbital and extra‐orbital skin before and after the trial.
Results
The patients reported satisfaction with the statistically significant reduction in hyperpigmentation achieved through carboxytherapy in the lateral (p = 0.002), middle (p = 0.001), and medial (p = 0.001) regions of the periorbital area. The total response rate of the patients was estimated at 20%. Patient satisfaction exceeded ΔE changes, with no significant linear relationship (p = 0.084).
Conclusion
Carboxytherapy can be proposed as an effective and safe treatment for periorbital hyperpigmentation.</description><subject>Carbon dioxide</subject><subject>carboxytherapy</subject><subject>CO2 therapy</subject><subject>dark eye circles</subject><subject>DECs</subject><subject>Effectiveness</subject><subject>eye dark circles</subject><subject>Humans</subject><subject>Hyperpigmentation</subject><subject>Hyperpigmentation - etiology</subject><subject>Hyperpigmentation - radiotherapy</subject><subject>infraorbital darkening</subject><subject>Iran</subject><subject>Original</subject><subject>Patient Satisfaction</subject><subject>Patients</subject><subject>periorbital darkening</subject><subject>periorbital hyperpigmentation</subject><subject>Pigmentation</subject><subject>Safety</subject><subject>Skin</subject><subject>Statistical analysis</subject><subject>trail</subject><subject>Treatment Outcome</subject><issn>0909-752X</issn><issn>1600-0846</issn><issn>1600-0846</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU1rFTEUhoMo9ra68A9IwI2FTpvczORjVaTUDygIWsFdOJNkenOZOxmTTHU2_nYzvbWoYDYhOU-ec8KL0AtKTmlZZynmU8p4Qx-hFeWEVETW_DFaEUVUJZr11wN0mNKWENIoyp6iAyZryUhDV-jnZdc5k_2tG1xKJzhB5_J8gmGweITs3ZDLXfapg0KFAYcOG4ht-DHnjYswzhhSoTHY7TTciXCODvJuedmFiEcXfYitz9DjzVxOo79ZirDonqEnHfTJPb_fj9CXt5fXF--rq4_vPly8uapMrSStgHKwtSHQWtk6ooziCpRqqWWkVCw3rJFW8c4IB9A2TspaKMHWAEoKa9kROt97x6ndOWtK_wi9HqPfQZx1AK__rgx-o2_CraZEMSmkKIbX94YYvk0uZb3zybi-h8GFKem1agTlgjNW0Ff_oNswxaH8r1BSUMHXzSI83lMmhpSi6x6moUQvseoSq76LtbAv_xz_gfydYwHO9sB337v5_yb9-dP1XvkLq-Oxbw</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Seirafianpour, Farnoosh</creator><creator>Atefi, Najmolsadat</creator><creator>Amin, Nazila Ghoreishi</creator><creator>Namazi, Mohammad Reza</creator><creator>Behrangi, Elham</creator><creator>Shafiei, Aboozar</creator><creator>Ghassemi, Mohammadreza</creator><creator>Mozafarpoor, Samaneh</creator><creator>Goodarzi, Azadeh</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3794-6206</orcidid><orcidid>https://orcid.org/0000-0002-1249-4429</orcidid></search><sort><creationdate>202403</creationdate><title>Effectiveness, safety, and patient satisfaction of carboxytherapy as an adjunctive treatment for periorbital hyperpigmentation</title><author>Seirafianpour, Farnoosh ; Atefi, Najmolsadat ; Amin, Nazila Ghoreishi ; Namazi, Mohammad Reza ; Behrangi, Elham ; Shafiei, Aboozar ; Ghassemi, Mohammadreza ; Mozafarpoor, Samaneh ; Goodarzi, Azadeh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4981-a16ad4c0abd8be09c969a99b1d306add6c358d96fc7eaab5e88479732aa987dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Carbon dioxide</topic><topic>carboxytherapy</topic><topic>CO2 therapy</topic><topic>dark eye circles</topic><topic>DECs</topic><topic>Effectiveness</topic><topic>eye dark circles</topic><topic>Humans</topic><topic>Hyperpigmentation</topic><topic>Hyperpigmentation - etiology</topic><topic>Hyperpigmentation - radiotherapy</topic><topic>infraorbital darkening</topic><topic>Iran</topic><topic>Original</topic><topic>Patient Satisfaction</topic><topic>Patients</topic><topic>periorbital darkening</topic><topic>periorbital hyperpigmentation</topic><topic>Pigmentation</topic><topic>Safety</topic><topic>Skin</topic><topic>Statistical analysis</topic><topic>trail</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seirafianpour, Farnoosh</creatorcontrib><creatorcontrib>Atefi, Najmolsadat</creatorcontrib><creatorcontrib>Amin, Nazila Ghoreishi</creatorcontrib><creatorcontrib>Namazi, Mohammad Reza</creatorcontrib><creatorcontrib>Behrangi, Elham</creatorcontrib><creatorcontrib>Shafiei, Aboozar</creatorcontrib><creatorcontrib>Ghassemi, Mohammadreza</creatorcontrib><creatorcontrib>Mozafarpoor, Samaneh</creatorcontrib><creatorcontrib>Goodarzi, Azadeh</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Skin research and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seirafianpour, Farnoosh</au><au>Atefi, Najmolsadat</au><au>Amin, Nazila Ghoreishi</au><au>Namazi, Mohammad Reza</au><au>Behrangi, Elham</au><au>Shafiei, Aboozar</au><au>Ghassemi, Mohammadreza</au><au>Mozafarpoor, Samaneh</au><au>Goodarzi, Azadeh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness, safety, and patient satisfaction of carboxytherapy as an adjunctive treatment for periorbital hyperpigmentation</atitle><jtitle>Skin research and technology</jtitle><addtitle>Skin Res Technol</addtitle><date>2024-03</date><risdate>2024</risdate><volume>30</volume><issue>3</issue><spage>e13651</spage><epage>n/a</epage><pages>e13651-n/a</pages><issn>0909-752X</issn><issn>1600-0846</issn><eissn>1600-0846</eissn><abstract>Introduction
Dark under‐eye circles or periorbital hyperpigmentation constitute a prevalent and challenging cosmetic problem with diverse etiologies and types. While modifying exacerbating habits can provide partial relief for the pigmentary and vascular factors associated with this condition, and despite the abundance of available treatment options, there is currently a lack of gold‐standard evidence‐based treatments proposed for curing this disorder.
Objectives
This study aimed to assess the safety and effectiveness of carboxytherapy in treating periorbital hyperpigmentation.
Material and Methods
In this 4‐week single‐arm clinical trial, 20 eligible Iranian patients with symmetric periorbital hyperpigmentation received weekly intradermal carboxytherapy. The treatment involved administering 10–20 mL of CO2 at a rate of 20 mL/min and a temperature of 15°C for a duration ranging from a few seconds to 1 min. Follow‐up assessments were conducted 1 month after the final session. The primary outcome was defined as the changes in ΔE or the variations in pigmentation observed between the orbital and extra‐orbital skin before and after the trial.
Results
The patients reported satisfaction with the statistically significant reduction in hyperpigmentation achieved through carboxytherapy in the lateral (p = 0.002), middle (p = 0.001), and medial (p = 0.001) regions of the periorbital area. The total response rate of the patients was estimated at 20%. Patient satisfaction exceeded ΔE changes, with no significant linear relationship (p = 0.084).
Conclusion
Carboxytherapy can be proposed as an effective and safe treatment for periorbital hyperpigmentation.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>38483051</pmid><doi>10.1111/srt.13651</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3794-6206</orcidid><orcidid>https://orcid.org/0000-0002-1249-4429</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Carbon dioxide carboxytherapy CO2 therapy dark eye circles DECs Effectiveness eye dark circles Humans Hyperpigmentation Hyperpigmentation - etiology Hyperpigmentation - radiotherapy infraorbital darkening Iran Original Patient Satisfaction Patients periorbital darkening periorbital hyperpigmentation Pigmentation Safety Skin Statistical analysis trail Treatment Outcome |
title | Effectiveness, safety, and patient satisfaction of carboxytherapy as an adjunctive treatment for periorbital hyperpigmentation |
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