Role of HCN channels in the functions of basal ganglia and Parkinson’s disease
Parkinson's disease (PD) is a motor disorder resulting from dopaminergic neuron degeneration in the substantia nigra caused by age, genetics, and environment. The disease severely impacts a patient’s quality of life and can even be life-threatening. The hyperpolarization-activated cyclic nucleo...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2024-12, Vol.81 (1), p.135-135, Article 135 |
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| description | Parkinson's disease (PD) is a motor disorder resulting from dopaminergic neuron degeneration in the substantia nigra caused by age, genetics, and environment. The disease severely impacts a patient’s quality of life and can even be life-threatening. The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel is a member of the HCN1-4 gene family and is widely expressed in basal ganglia nuclei. The hyperpolarization-activated current mediated by the HCN channel has a distinct impact on neuronal excitability and rhythmic activity associated with PD pathogenesis, as it affects the firing activity, including both firing rate and firing pattern, of neurons in the basal ganglia nuclei. This review aims to comprehensively understand the characteristics of HCN channels by summarizing their regulatory role in neuronal firing activity of the basal ganglia nuclei. Furthermore, the distribution and characteristics of HCN channels in each nucleus of the basal ganglia group and their effect on PD symptoms through modulating neuronal electrical activity are discussed. Since the roles of the substantia nigra pars compacta and reticulata, as well as globus pallidus externus and internus, are distinct in the basal ganglia circuit, they are individually described. Lastly, this investigation briefly highlights that the HCN channel expressed on microglia plays a role in the pathological process of PD by affecting the neuroinflammatory response. |
| doi_str_mv | 10.1007/s00018-024-05163-w |
| format | Article |
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The disease severely impacts a patient’s quality of life and can even be life-threatening. The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel is a member of the HCN1-4 gene family and is widely expressed in basal ganglia nuclei. The hyperpolarization-activated current mediated by the HCN channel has a distinct impact on neuronal excitability and rhythmic activity associated with PD pathogenesis, as it affects the firing activity, including both firing rate and firing pattern, of neurons in the basal ganglia nuclei. This review aims to comprehensively understand the characteristics of HCN channels by summarizing their regulatory role in neuronal firing activity of the basal ganglia nuclei. Furthermore, the distribution and characteristics of HCN channels in each nucleus of the basal ganglia group and their effect on PD symptoms through modulating neuronal electrical activity are discussed. Since the roles of the substantia nigra pars compacta and reticulata, as well as globus pallidus externus and internus, are distinct in the basal ganglia circuit, they are individually described. Lastly, this investigation briefly highlights that the HCN channel expressed on microglia plays a role in the pathological process of PD by affecting the neuroinflammatory response.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-024-05163-w</identifier><identifier>PMID: 38478096</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Basal ganglia ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Channels ; Degeneration ; Dopamine receptors ; Excitability ; Firing pattern ; Ganglia ; Genetics ; Globus pallidus ; Hyperpolarization ; Inflammation ; Ion channels (cyclic nucleotide-gated) ; Life Sciences ; Microglia ; Movement disorders ; Neurodegeneration ; Neurodegenerative diseases ; Nuclei ; Nucleotides ; Parkinson's disease ; Pathogenesis ; Quality of life ; Review ; Signs and symptoms ; Substantia nigra</subject><ispartof>Cellular and molecular life sciences : CMLS, 2024-12, Vol.81 (1), p.135-135, Article 135</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c426t-203ca6c6a41936ca9051f0cc5a42b731772904de18d48d4ed660a2916956d2173</cites><orcidid>0000-0002-7784-4688</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10937777/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10937777/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,41127,41495,42196,42564,51326,51583,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38478096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qi, Zeng-Xin</creatorcontrib><creatorcontrib>Yan, Qi</creatorcontrib><creatorcontrib>Fan, Xiu-Juan</creatorcontrib><creatorcontrib>Peng, Jian-Ya</creatorcontrib><creatorcontrib>Zhu, Hui-Xian</creatorcontrib><creatorcontrib>Jiang, Yi-Miao</creatorcontrib><creatorcontrib>Chen, Liang</creatorcontrib><creatorcontrib>Zhuang, Qian-Xing</creatorcontrib><title>Role of HCN channels in the functions of basal ganglia and Parkinson’s disease</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Parkinson's disease (PD) is a motor disorder resulting from dopaminergic neuron degeneration in the substantia nigra caused by age, genetics, and environment. The disease severely impacts a patient’s quality of life and can even be life-threatening. The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel is a member of the HCN1-4 gene family and is widely expressed in basal ganglia nuclei. The hyperpolarization-activated current mediated by the HCN channel has a distinct impact on neuronal excitability and rhythmic activity associated with PD pathogenesis, as it affects the firing activity, including both firing rate and firing pattern, of neurons in the basal ganglia nuclei. This review aims to comprehensively understand the characteristics of HCN channels by summarizing their regulatory role in neuronal firing activity of the basal ganglia nuclei. Furthermore, the distribution and characteristics of HCN channels in each nucleus of the basal ganglia group and their effect on PD symptoms through modulating neuronal electrical activity are discussed. Since the roles of the substantia nigra pars compacta and reticulata, as well as globus pallidus externus and internus, are distinct in the basal ganglia circuit, they are individually described. Lastly, this investigation briefly highlights that the HCN channel expressed on microglia plays a role in the pathological process of PD by affecting the neuroinflammatory response.</description><subject>Basal ganglia</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Channels</subject><subject>Degeneration</subject><subject>Dopamine receptors</subject><subject>Excitability</subject><subject>Firing pattern</subject><subject>Ganglia</subject><subject>Genetics</subject><subject>Globus pallidus</subject><subject>Hyperpolarization</subject><subject>Inflammation</subject><subject>Ion channels (cyclic nucleotide-gated)</subject><subject>Life Sciences</subject><subject>Microglia</subject><subject>Movement disorders</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>Nuclei</subject><subject>Nucleotides</subject><subject>Parkinson's disease</subject><subject>Pathogenesis</subject><subject>Quality of life</subject><subject>Review</subject><subject>Signs and symptoms</subject><subject>Substantia nigra</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kd9uFCEUxomxsbXtC3hhSLzxZtoDw8BwZcxGrUnTNk1NvCNnGWaXOgsVZmy88zV8PZ9Etrutfy5KSCA5v_PBdz5CXjA4YgDqOAMAayvgooKGybq6fUL2mOBQaVDs6fYuW_55lzzP-brQTcvlM7Jbt0K1oOUeubiMg6OxpyezM2qXGIIbMvWBjktH-ynY0ceQ18AcMw50gWExeKQYOnqB6YsPOYZfP35m2vnsMLsDstPjkN3h9twnn96_u5qdVKfnHz7O3p5WVnA5Vhxqi9JKFEzX0qIuDnqwtkHB56pmSnENonOs7UTZrpMSkGsmdSM7zlS9T95sdG-m-cp11oUx4WBukl9h-m4ievNvJfilWcRvhoGuVVlF4fVWIcWvk8ujWfls3TBgcHHKhutGlamqRhf01X_odZxSKP7WlBRtW8ZZKL6hbIo5J9c__IaBWSdmNomZkpi5S8zclqaXf_t4aLmPqAD1BsilFBYu_Xn7EdnfIs2hjg</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Qi, Zeng-Xin</creator><creator>Yan, Qi</creator><creator>Fan, Xiu-Juan</creator><creator>Peng, Jian-Ya</creator><creator>Zhu, Hui-Xian</creator><creator>Jiang, Yi-Miao</creator><creator>Chen, Liang</creator><creator>Zhuang, Qian-Xing</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7784-4688</orcidid></search><sort><creationdate>20241201</creationdate><title>Role of HCN channels in the functions of basal ganglia and Parkinson’s disease</title><author>Qi, Zeng-Xin ; 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Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>81</volume><issue>1</issue><spage>135</spage><epage>135</epage><pages>135-135</pages><artnum>135</artnum><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Parkinson's disease (PD) is a motor disorder resulting from dopaminergic neuron degeneration in the substantia nigra caused by age, genetics, and environment. The disease severely impacts a patient’s quality of life and can even be life-threatening. The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel is a member of the HCN1-4 gene family and is widely expressed in basal ganglia nuclei. The hyperpolarization-activated current mediated by the HCN channel has a distinct impact on neuronal excitability and rhythmic activity associated with PD pathogenesis, as it affects the firing activity, including both firing rate and firing pattern, of neurons in the basal ganglia nuclei. This review aims to comprehensively understand the characteristics of HCN channels by summarizing their regulatory role in neuronal firing activity of the basal ganglia nuclei. Furthermore, the distribution and characteristics of HCN channels in each nucleus of the basal ganglia group and their effect on PD symptoms through modulating neuronal electrical activity are discussed. Since the roles of the substantia nigra pars compacta and reticulata, as well as globus pallidus externus and internus, are distinct in the basal ganglia circuit, they are individually described. Lastly, this investigation briefly highlights that the HCN channel expressed on microglia plays a role in the pathological process of PD by affecting the neuroinflammatory response.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>38478096</pmid><doi>10.1007/s00018-024-05163-w</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7784-4688</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Basal ganglia Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Channels Degeneration Dopamine receptors Excitability Firing pattern Ganglia Genetics Globus pallidus Hyperpolarization Inflammation Ion channels (cyclic nucleotide-gated) Life Sciences Microglia Movement disorders Neurodegeneration Neurodegenerative diseases Nuclei Nucleotides Parkinson's disease Pathogenesis Quality of life Review Signs and symptoms Substantia nigra |
| title | Role of HCN channels in the functions of basal ganglia and Parkinson’s disease |
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