Protective effect of selenium and vitamin C on the fertility of male rats given penconazole
Penconazole is used in agriculture and human and veterinary medicine applications. It has been included in the acute toxicity hazard category by the WHO. This study examines the protective effect of selenium and vitamin C on the fertility of male rats given penconazole. Nine groups of rats were give...
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| Veröffentlicht in: | JBRA assisted reproduction 2024-01, Vol.28 (1), p.27-32 |
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| creator | Shams, Elaheh Abdollahi, Vahideh Harfsheno, Mozhgan Ghasemian, Seyedeh Ommolbanin |
| description | Penconazole is used in agriculture and human and veterinary medicine applications. It has been included in the acute toxicity hazard category by the WHO. This study examines the protective effect of selenium and vitamin C on the fertility of male rats given penconazole.
Nine groups of rats were given penconazole at concentrations of 50 and 75 mg/ml and selenium and vitamin C at concentrations of 0.5 and 100 mg/ml, respectively. Serum levels of LH and FSH were measured with ELISA kits; β-actin, GPX4, AQP7, PRM2, and BAX gene expression was evaluated with real-time PCR performed on the left testis of each rat.
LH, FSH, and testosterone levels were lower in the groups given penconazole (50 and 75 mg/kg). Histopathology showed that the groups given penconazole had the lowest number of spermatogonia and primary spermatocytes; these numbers were greater in the groups receiving penconazole together with selenium or vitamin C; and the highest counts were observed in separate groups given Se and vitamin C. GPX4, AQP7, PRM2 and BAX gene expression in the groups receiving penconazole was different from controls and was modulated by treatment with selenium or vitamin C.
This study showed that antioxidant compounds have a strengthening effect on the reproductive system and can mitigate the destructive effects of chemical fungicides. |
| doi_str_mv | 10.5935/1518-0557.20230042 |
| format | Article |
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Nine groups of rats were given penconazole at concentrations of 50 and 75 mg/ml and selenium and vitamin C at concentrations of 0.5 and 100 mg/ml, respectively. Serum levels of LH and FSH were measured with ELISA kits; β-actin, GPX4, AQP7, PRM2, and BAX gene expression was evaluated with real-time PCR performed on the left testis of each rat.
LH, FSH, and testosterone levels were lower in the groups given penconazole (50 and 75 mg/kg). Histopathology showed that the groups given penconazole had the lowest number of spermatogonia and primary spermatocytes; these numbers were greater in the groups receiving penconazole together with selenium or vitamin C; and the highest counts were observed in separate groups given Se and vitamin C. GPX4, AQP7, PRM2 and BAX gene expression in the groups receiving penconazole was different from controls and was modulated by treatment with selenium or vitamin C.
This study showed that antioxidant compounds have a strengthening effect on the reproductive system and can mitigate the destructive effects of chemical fungicides.</description><identifier>ISSN: 1517-5693</identifier><identifier>EISSN: 1518-0557</identifier><identifier>DOI: 10.5935/1518-0557.20230042</identifier><identifier>PMID: 37962947</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</publisher><subject>Abdomen ; Animals ; Antioxidants ; Ascorbic Acid - pharmacology ; bcl-2-Associated X Protein - pharmacology ; Fertility ; Follicle Stimulating Hormone ; Fungicides ; Humans ; Infertility ; Laboratory animals ; Male ; Original ; Pesticides ; Rats ; Selenium ; Selenium - pharmacology ; Sperm ; Spermatogenesis ; Testes ; Triazoles ; Vitamin C</subject><ispartof>JBRA assisted reproduction, 2024-01, Vol.28 (1), p.27-32</ispartof><rights>2024. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936918/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936918/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37962947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shams, Elaheh</creatorcontrib><creatorcontrib>Abdollahi, Vahideh</creatorcontrib><creatorcontrib>Harfsheno, Mozhgan</creatorcontrib><creatorcontrib>Ghasemian, Seyedeh Ommolbanin</creatorcontrib><title>Protective effect of selenium and vitamin C on the fertility of male rats given penconazole</title><title>JBRA assisted reproduction</title><addtitle>JBRA Assist Reprod</addtitle><description>Penconazole is used in agriculture and human and veterinary medicine applications. It has been included in the acute toxicity hazard category by the WHO. This study examines the protective effect of selenium and vitamin C on the fertility of male rats given penconazole.
Nine groups of rats were given penconazole at concentrations of 50 and 75 mg/ml and selenium and vitamin C at concentrations of 0.5 and 100 mg/ml, respectively. Serum levels of LH and FSH were measured with ELISA kits; β-actin, GPX4, AQP7, PRM2, and BAX gene expression was evaluated with real-time PCR performed on the left testis of each rat.
LH, FSH, and testosterone levels were lower in the groups given penconazole (50 and 75 mg/kg). Histopathology showed that the groups given penconazole had the lowest number of spermatogonia and primary spermatocytes; these numbers were greater in the groups receiving penconazole together with selenium or vitamin C; and the highest counts were observed in separate groups given Se and vitamin C. GPX4, AQP7, PRM2 and BAX gene expression in the groups receiving penconazole was different from controls and was modulated by treatment with selenium or vitamin C.
This study showed that antioxidant compounds have a strengthening effect on the reproductive system and can mitigate the destructive effects of chemical fungicides.</description><subject>Abdomen</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Ascorbic Acid - pharmacology</subject><subject>bcl-2-Associated X Protein - pharmacology</subject><subject>Fertility</subject><subject>Follicle Stimulating Hormone</subject><subject>Fungicides</subject><subject>Humans</subject><subject>Infertility</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>Original</subject><subject>Pesticides</subject><subject>Rats</subject><subject>Selenium</subject><subject>Selenium - pharmacology</subject><subject>Sperm</subject><subject>Spermatogenesis</subject><subject>Testes</subject><subject>Triazoles</subject><subject>Vitamin C</subject><issn>1517-5693</issn><issn>1518-0557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkE1LxDAQhoMoruj-AQ8S8OKla77TnEQWv2BBD3ryUNJ0qlnaZG3TBf311q9FPc3LzMPDzCB0SMlMGi5PqaR5RqTUM0YYJ0SwLbS3aW5_Zp1JZfgETft-SQihhjIuyC6acG0UM0Lvoce7LiZwya8BQ12PCcca99BA8EOLbajw2ifb-oDnOAacngHX0CXf-PT6gba2AdzZ1OOn0RHwCoKLwb7FBg7QTm2bHqbfdR89XF7cz6-zxe3Vzfx8ka2YkSmjVgrBayd4ySptbG4h17XKlSacqoqWylGr6tIZJxyhLC-tUqWxtOKEcqH5Pjr78q6GsoXKQUidbYpV51vbvRbR-uLvJPjn4imuC0oMV4bmo-Hk29DFlwH6VLS-d9A0NkAc-oLlhnAlRP6BHv9Dl3HownhfwQljkhgt6Ugd_V5ps8vP4_k7lueGmA</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Shams, Elaheh</creator><creator>Abdollahi, Vahideh</creator><creator>Harfsheno, Mozhgan</creator><creator>Ghasemian, Seyedeh Ommolbanin</creator><general>Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</general><general>Brazilian Society of Assisted Reproduction</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240101</creationdate><title>Protective effect of selenium and vitamin C on the fertility of male rats given penconazole</title><author>Shams, Elaheh ; 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It has been included in the acute toxicity hazard category by the WHO. This study examines the protective effect of selenium and vitamin C on the fertility of male rats given penconazole.
Nine groups of rats were given penconazole at concentrations of 50 and 75 mg/ml and selenium and vitamin C at concentrations of 0.5 and 100 mg/ml, respectively. Serum levels of LH and FSH were measured with ELISA kits; β-actin, GPX4, AQP7, PRM2, and BAX gene expression was evaluated with real-time PCR performed on the left testis of each rat.
LH, FSH, and testosterone levels were lower in the groups given penconazole (50 and 75 mg/kg). Histopathology showed that the groups given penconazole had the lowest number of spermatogonia and primary spermatocytes; these numbers were greater in the groups receiving penconazole together with selenium or vitamin C; and the highest counts were observed in separate groups given Se and vitamin C. GPX4, AQP7, PRM2 and BAX gene expression in the groups receiving penconazole was different from controls and was modulated by treatment with selenium or vitamin C.
This study showed that antioxidant compounds have a strengthening effect on the reproductive system and can mitigate the destructive effects of chemical fungicides.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</pub><pmid>37962947</pmid><doi>10.5935/1518-0557.20230042</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abdomen Animals Antioxidants Ascorbic Acid - pharmacology bcl-2-Associated X Protein - pharmacology Fertility Follicle Stimulating Hormone Fungicides Humans Infertility Laboratory animals Male Original Pesticides Rats Selenium Selenium - pharmacology Sperm Spermatogenesis Testes Triazoles Vitamin C |
| title | Protective effect of selenium and vitamin C on the fertility of male rats given penconazole |
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